DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sktl and PIKFYVE

DIOPT Version :9

Sequence 1:	NP_001286646.1	Gene:	sktl / 37356	FlyBaseID:	FBgn0016984	Length:	792	Species:	Drosophila melanogaster
Sequence 2:	XP_011509080.1	Gene:	PIKFYVE / 200576	HGNCID:	23785	Length:	2110	Species:	Homo sapiens

Alignment Length:	552	Identity:	118/552 - (21%)
Similarity:	183/552 - (33%)	Gaps:	197/552 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 IPPAQTA-SPDQEATPSTPPPMSLQPGTSRQLFRDAAMAHGGQETTSLLQQELNNIAATQTPASK 111
            :|...|: |..:.::|...|.||                 |||...:           |:|....
Human  1712 LPTNSTSDSRPKSSSPIRLPEMS-----------------GGQTNRT-----------TETEPQP 1748

  Fly   112 LRSASSTLD---ASISRNPSTTGGKHEKKLGHRRVAEGGEVTYKKIQSKQIMGSIQLGIQHTVGS 173
            .:.||..|.   .:..::|..:..|       |....|.:..|.::......|:...|::.....
Human  1749 TKKASGMLSFFRGTAGKSPDLSSQK-------RETLRGADSAYYQVGQTGKEGTENQGVEPQDEV 1806

  Fly   174 LASKPKRDLLMNDFWEMETISFPPDGSSITPAHHYNDFRFKVYAPI----AFRYFRD-LFGIAPD 233
            .....::..|:|...|::                ::|...|.|..:    .|...|: :...:.:
Human  1807 DGGDTQKKQLINPHVELQ----------------FSDANAKFYCRLYYAGEFHKMREVILDSSEE 1855

  Fly   234 DFLMSMC-ASPLRELSNPGASGSIFYLTTDDEFIIKTVQKKECEFLQKLLPGYY---MNLSQNPR 294
            ||:.|:. :||.:  :..|.||:.||.|.||.||:|.:.:.|.:......|.|:   .|..|..|
Human  1856 DFIRSLSHSSPWQ--ARGGKSGAAFYATEDDRFILKQMPRLEVQSFLDFAPHYFNYITNAVQQKR 1918

  Fly   295 -TLLPKFFGLYCFHY-NSKN-----VRLVAMNNLLPSDIKMHCKYDLKGSSFRRKASKAERQKAS 352
             |.|.|..|:|...| ||:|     :.|:.|.||.... ||...:|||| |.|.:..|.:..|.|
Human  1919 PTALAKILGVYRIGYKNSQNNTEKKLDLLVMENLFYGR-KMAQVFDLKG-SLRNRNVKTDTGKES 1981

  Fly   353 PTFKDLDFAEH-----HPNGIFLETDKYNALMSTIKRDCMVLESFQIMDYSLLVGIHNLDLAAKE 412
            .....||  |:     ..|.:::.:.....|.::|..|...|.|..|:|||||||
Human  1982 CDVVLLD--ENLLKMVRDNPLYIRSHSKAVLRTSIHSDSHFLSSHLIIDYSLLVG---------- 2034

  Fly   413 KREERILNARAKLQRKESAAQGPPSLNPDDDAPEADQNQLQAVASYASIPGTSAGAALNRTRSMN 477
                                       .||.:.|
Human  2035 ---------------------------RDDTSNE------------------------------- 2041

  Fly   478 RQRLVAHSTALESITADMDVPLEEDEDVPAGGIPARSENDERLILYIGIIDILQSYRLEKKLEHT 542
                                                        |.:||||.::::..:||||..
Human  2042 --------------------------------------------LVVGIIDYIRTFTWDKKLEMV 2062

  Fly   543 FKS--IL-YNGDTVSVCRPSFYAKRFQDAMGK 571
            .||  || ..|...:|..|..|..||.:||.|
Human  2063 VKSTGILGGQGKMPTVVSPELYRTRFCEAMDK 2094

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sktl	NP_001286646.1	PIPKc	183..573	CDD:214623	96/413 (23%)
PIKFYVE	XP_011509080.1	FYVE_PIKfyve_Fab1	166..227	CDD:277264
		DEP_PIKfyve	369..450	CDD:239895
		Fab1_TCP	629..889	CDD:239450
		PIPKc	1784..2097	CDD:238081	99/445 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5253
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810