Protein Alignment sktl and Pip4k2c

DIOPT Version :10

• Sequence 1: NP_477206.1
• Gene: sktl / 37356
• FlyBaseID: FBgn0016984
• Length: 792
• Species: Drosophila melanogaster
• Sequence 2: NP_536728.2
• Gene: Pip4k2c / 140607
• RGDID: 621711
• Length: 421
• Species: Rattus norvegicus
• Alignment Length: 483
• Identity: 126/483 - (26%)
• Similarity: 210/483 - (43%)
• Gaps: 100/483 - (20%)

  Fly   115 ASSTLDASISRNPSTTGG-------------KH--EKKLGHRRVAEGGEVTYKKIQSKQIMGSIQ 164
            |||::..:.:  |:..||             ||  ::|:...|.|:            .::|...
  Rat     2 ASSSVPPATA--PAAAGGPGPGFGFASKTKKKHFVQQKVKVFRAAD------------PLVGVFL 52

  Fly   165 LGIQHTVGSLASKPKRDLLMNDFWEMETISFPPDGSSITPAHHY-------NDFRFKVYAPIAFR 222
            .|:.|::..|:..|...:|:.|.::.        .|.|...:|.       :.|:||.|.|..||
  Rat    53 WGVAHSINELSQVPPPVMLLPDDFKA--------SSKIKVNNHLFHRENLPSHFKFKEYCPQVFR 109

  Fly   223 YFRDLFGIAPDDFLMSMCASPLRELSNPGASGSIFYLTTDDEFIIKTVQKKECEFLQKLLPGYYM 287
            ..||.|.|...|:|:|:..||..|  ..|:.|. |.::.|...:||.|..::...:...|..|:.
  Rat   110 NLRDRFAIDDHDYLVSLTRSPPSE--TEGSDGR-FLISYDRTLVIKEVSSEDIADMHSNLSNYHQ 171

  Fly   288 NLSQ-NPRTLLPKFFGLYCFHYNSKNVRLVAMNNLLPSDIKMHCKYDLKGSSFRRKASKAERQKA 351
            .:.: :..||||:|.|:|.....:::..::.|.|:....:.:|.|||||||...|:||..|:.|.
  Rat   172 YIVKCHGNTLLPQFLGMYRVSVENEDSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKE 236

  Fly   352 SPTFKDLDFAEHHPNGIFLETDKYNALMSTIKRDCMVLESFQIMDYSLLVGIHNLDLAAKEKREE 416
            .||.||:||...:.. :::..::....:..:|||...|...:|||||||:|||:: :...|..||
  Rat   237 LPTLKDMDFLNKNQK-VYIGEEEKKVFLEKLKRDVEFLVQLKIMDYSLLLGIHDI-IRGSEPEEE 299

  Fly   417 RILNARAKLQRKESA------AQGPPSLNPDDDAPEADQNQLQAVASYASIPGTSAGAALNRTRS 475
                  ..::.:||.      ..|||:|                |.||.:.| ...|..::..|.
  Rat   300 ------GPVREEESEWDGDCNLTGPPAL----------------VGSYGTSP-EGIGGYIHSHRP 341

  Fly   476 MNRQRLVAHSTALESITADMDVPLEEDEDVPAGGIPARSENDERLILYIGIIDILQSYRLEKKLE 540
            :.                    |.|.:..:....|.:.....::.:.::|:||||..|..:||..
  Rat   342 LG--------------------PGEFESFIDVYAIRSAEGAPQKEVYFMGLIDILTQYDAKKKAA 386

  Fly   541 HTFKSILYN-GDTVSVCRPSFYAKRFQD 567
            |..|::.:. |..:|...|..|||||.|
  Rat   387 HAAKTVKHGAGAEISTVHPEQYAKRFLD 414

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sktl	NP_477206.1	PIPKc_PIP5KI	158..577	CDD:340438	115/425 (27%)
Pip4k2c	NP_536728.2	PIPKc_PIP5K2C	46..418	CDD:340448	115/425 (27%)
		Required for interaction with PIP5K1A. /evidence=ECO:0000250|UniProtKB:Q8TBX8	69..75		1/5 (20%)