DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sktl and PIP5KL1

DIOPT Version :9

Sequence 1:	NP_001286646.1	Gene:	sktl / 37356	FlyBaseID:	FBgn0016984	Length:	792	Species:	Drosophila melanogaster
Sequence 2:	NP_001128691.1	Gene:	PIP5KL1 / 138429	HGNCID:	28711	Length:	394	Species:	Homo sapiens

Alignment Length:	443	Identity:	96/443 - (21%)
Similarity:	169/443 - (38%)	Gaps:	94/443 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 GHRRVAEGGEVTYKKIQSKQI-MGSIQLGIQHTVGSLASKPKRDLLMNDFWEMETISF--PPDG- 199
            |.|.|.........:::.||. :|..::...|.:..:..     ::....|....:|.  ||.|
Human    19 GCRAVTSSRRGLLWRLRDKQSRLGLFEISPGHELHGMTC-----MMQAGLWAATQVSMDHPPTGP 78

  Fly   200 -------SSITPAHHYNDFRFKVYAPIAFRYFRDLFGIAPDDFLMSM-CASPLRELSNPGASGSI 256
                   ..:|..|  ..|.....|..||.:.|...|:|.:|:..:: ...|..:..:...|.:.
Human    79 PSRDDFSEVLTQVH--EGFELGTLAGPAFAWLRRSLGLAEEDYQAALGPGGPYLQFLSTSKSKAS 141

  Fly   257 FYLTTDDEFIIKTVQKKECEFLQKLLPGYYMNLSQNPRTLLPKFFGLYCFHYN-SKNVRLVAMNN 320
            |:|:.|..|.:||..::|.:.|...||.|..:|.::|.:||.:..|::....: .|....:.|.:
Human   142 FFLSHDQRFFLKTQGRREVQALLAHLPRYVQHLQRHPHSLLARLLGVHSLRVDRGKKTYFIVMQS 206

  Fly   321 LLPSDIKMHCKYDLKGSSFRRKASKAERQKASP---TFKDLDFAEHHPNGIFLETDKYNA-LMST 381
            :.....::..:||:||....|....|  .:.||   ..|||:|     .|..:......: .:..
Human   207 VFYPAGRISERYDIKGCEVSRWVDPA--PEGSPLVLVLKDLNF-----QGKTINLGPQRSWFLRQ 264

  Fly   382 IKRDCMVLESFQIMDYSLLVGIHNLDLAAKEKREERILNARAKLQRKESAAQGPPSLNPDDDAPE 446
            ::.|...|....::|||||:....|       .|:......:.:.|...:.||..|       ||
Human   265 MELDTTFLRELNVLDYSLLIAFQRL-------HEDERGPGSSLIFRTARSVQGAQS-------PE 315

  Fly   447 ADQNQLQAVASYASIPGTSAGAALNRTRSMNRQRLVAHSTALESITADMDVPLEEDEDVPAGGIP 511
                                     .:|:.||:.|.....||..:            |.|
Human   316 -------------------------ESRAQNRRLLPDAPNALHIL------------DGP----- 338

  Fly   512 ARSENDERLILYIGIIDILQSYRLEKKLEHTFKSILYNGDTVSVCRPSFYAKR 564
                 ::|  .::|::|:...|.|.|:|||.:|::.|.|.|.|...|:.||:|
Human   339 -----EQR--YFLGVVDLATVYGLRKRLEHLWKTLRYPGRTFSTVSPARYARR 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sktl	NP_001286646.1	PIPKc	183..573	CDD:214623	89/398 (22%)
PIP5KL1	NP_001128691.1	PIP5K	128..392	CDD:279801	74/327 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5253
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1562683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23086
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920