Protein Alignment sktl and Pip4k2a

DIOPT Version :10

• Sequence 1: NP_477206.1
• Gene: sktl / 37356
• FlyBaseID: FBgn0016984
• Length: 792
• Species: Drosophila melanogaster
• Sequence 2: NP_446378.1
• Gene: Pip4k2a / 116723
• RGDID: 621708
• Length: 406
• Species: Rattus norvegicus
• Alignment Length: 476
• Identity: 119/476 - (25%)
• Similarity: 201/476 - (42%)
• Gaps: 100/476 - (21%)

  Fly   117 STLDASISRNPSTTGGKHEKKLGHRRVAEGGEVTYKKIQ----SKQIMGSIQLGIQHTVGSLA-- 175
            |.|.:|:..:.:.|..||              ...:|::    |..::..:..|:.|::..|:
  Rat     5 SNLGSSVLASKTKTKKKH--------------FVAQKVKLFRASDPLLSVLMWGVNHSINELSHV 55

  Fly   176 --------------SKPKRDLLMNDFWEMETISFPPDGSSITPAHHYNDFRFKVYAPIAFRYFRD 226
                          ||.|.|   |..:..|.:          |:|    |:||.|.|:.||..|:
  Rat    56 QIPVMLMPDDFKAYSKIKVD---NHLFNKENM----------PSH----FKFKEYCPMVFRNLRE 103

  Fly   227 LFGIAPDDFLMSMCASPLRELSNPGASGSIFYLTTDDEFIIKTVQKKECEFLQKLLPGYYMNLSQ 291
            .|||...||..|:..|......:...||:.|:.:.|..::|||:..::...:..:|..|:..:.:
  Rat   104 RFGIDDQDFQNSLTRSAPLPNDSQARSGARFHTSYDKRYVIKTITSEDVAEMHNILKKYHQYIVE 168

  Fly   292 -NPRTLLPKFFGLYCFHYNSKNVRLVAMNNLLPSDIKMHCKYDLKGSSFRRKASKAERQKASPTF 355
             :..||||:|.|:|..:.:...:.::...|:....:.::.|||||||:..|:||..|:.|..||.
  Rat   169 CHGVTLLPQFLGMYRLNVDGVEIYVIVTRNVFSHRLSVYRKYDLKGSTVAREASDKEKAKELPTL 233

  Fly   356 KDLDFAEHHPNGIFLETDKYNALMSTIKRDCMVLESFQIMDYSLLVGIHNLDLAAKEKREERILN 420
            ||.||. :....|:::.......:..:|:|...|...::||||||||||:::.|.:|:.|
  Rat   234 KDNDFI-NEGQKIYIDDSNKKIFLEKLKKDVEFLAQLKLMDYSLLVGIHDVERAEQEEVE----- 292

  Fly   421 ARAKLQRKESAAQGPPSLNPDDDAPEADQNQLQAVASYASIPGTSAGAALNRTRSMNRQRLVAHS 485
                .:..|...:|           |:|.      |.....|..|.|..||.:..:
  Rat   293 ----CEENEGEEEG-----------ESDG------AHPIGTPPDSPGNTLNSSPPL--------- 327

  Fly   486 TALESITADMDVPLEEDEDVPAGGIPARSENDERLILYIGIIDILQSYRLEKKLEHTFKSILYN- 549
                       .|.|.|.::....|........:.:.::.|||||..|..:||..|..|::.:.
  Rat   328 -----------APGEFDPNIDVYAIKCHENAPRKEVYFMAIIDILTHYDAKKKAAHAAKTVKHGA 381

  Fly   550 GDTVSVCRPSFYAKRFQDAMG 570
            |..:|...|..|:|||.|.:|
  Rat   382 GAEISTVNPEQYSKRFLDFIG 402

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sktl	NP_477206.1	PIPKc_PIP5KI	158..577	CDD:340438	111/431 (26%)
Pip4k2a	NP_446378.1	PIPKc_PIP5K2A	27..403	CDD:340446	113/440 (26%)
		Required for interaction with PIP5K1A. /evidence=ECO:0000250|UniProtKB:Q8TBX8	59..65		0/5 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	287..328		12/86 (14%)