DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sktl and pip5kl1

DIOPT Version :9

Sequence 1:	NP_001286646.1	Gene:	sktl / 37356	FlyBaseID:	FBgn0016984	Length:	792	Species:	Drosophila melanogaster
Sequence 2:	XP_021327291.1	Gene:	pip5kl1 / 100149843	ZFINID:	ZDB-GENE-060526-248	Length:	470	Species:	Danio rerio

Alignment Length:	500	Identity:	121/500 - (24%)
Similarity:	192/500 - (38%)	Gaps:	110/500 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 SISRNPSTT-----GGKHE--KKLGHRRVAEGGEVTYKKIQSKQIMGSIQLGIQHTVGSLASKPK 179
            |::|...|.     ||..:  |.||...:.:..|........|:   .::..:|:|:    ..|.
Zfish    14 SVNRRSRTVKRRRWGGLRQQWKLLGLFEIDQEHEFHSLTCMMKE---GLRAAVQNTI----DNPL 71

  Fly   180 RDLLMNDFWEMETISFPPDGSSITPAHHYNDFRFKVYAPIAFRYFRDLFGIAPDDFLMSMCASP- 243
            .|.|..|.:.:|          :|..|  .|||.:.||...|...|...|:...::..|:.:..
Zfish    72 PDELCEDDYSLE----------VTQIH--KDFRMETYAGPVFASLRRSLGMTEKEYQQSLSSEGC 124

  Fly   244 -LRELSNPGASGSIFYLTTDDEFIIKTVQKKECEFLQKLLPGYYMNLSQNPRTLLPKFFGLYCFH 307
             |:.:|| ..|.:.|:||.|..|.:||..|:|..||...|..|..:|.:.|.:||.||.|::...
Zfish   125 YLQFISN-SKSKADFFLTNDKRFFLKTQSKREVRFLLSNLRIYMEHLEKYPHSLLVKFLGVHRIK 188

  Fly   308 Y-NSKNVRLVAMNNLLPSDIKMHCKYDLKGSSFRRKASKA-ERQKASPTFKDLDFAEHHPNGIFL 370
            . |.:....:.|.::...|.::..:||:||....|....| |........|||:|     .|.|:
Zfish   189 IANQRKKYFIVMQSVFYPDDRIMARYDIKGCEVSRWTDPAPEGSHIIVVLKDLNF-----EGQFI 248

  Fly   371 ETDKYNA-LMSTIKRDCMVLESFQIMDYSLLVG---IHNLDLA---------AKEKREERILNAR 422
            ..|:... |:..::.|...|::..::|||||:.   :|..:|:         .:.|:.....:.|
Zfish   249 HLDQQRPWLLRQVEIDTAFLQTLNVLDYSLLLAHQPLHQDELSQSLSFATLIMRTKKSFPFFSKR 313

  Fly   423 AKLQRKESAAQGP--------PSLNPDDDAPE---------------------ADQNQLQAVASY 458
            ....|..:....|        |.:..|:|:..                     .|...|:.
Zfish   314 PLAGRSVNPVSSPTHAASPTVPGVVADEDSSPLPSELNCTHNSHITECSGNDGMDNTSLEG---- 374

  Fly   459 ASIPGTS-AGAA---LNRTRSMNRQRLVAHSTALESITADMDVPLEEDEDVPAGGIPARSENDER 519
            .:|.|.| |||.   |...:|.||:.|......|..|            |.|          ::|
Zfish   375 ENIEGPSRAGAESADLQAFQSQNRRLLPNFKNPLHVI------------DGP----------EQR 417

  Fly   520 LILYIGIIDILQSYRLEKKLEHTFKSILYNGDTVSVCRPSFYAKR 564
              .:||||||...|...|:|||.:|.:.:...|.|...|..|..|
Zfish   418 --YFIGIIDIFTVYGFRKRLEHLWKRLRHPSQTFSTVSPPAYCHR 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sktl	NP_001286646.1	PIPKc	183..573	CDD:214623	106/431 (25%)
pip5kl1	XP_021327291.1	PIP5K	124..468	CDD:307586	92/370 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5253
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1562683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23086
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920