DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sktl and pip5k1cb

DIOPT Version :9

Sequence 1:	NP_001286646.1	Gene:	sktl / 37356	FlyBaseID:	FBgn0016984	Length:	792	Species:	Drosophila melanogaster
Sequence 2:	XP_005171520.1	Gene:	pip5k1cb / 100005033	ZFINID:	ZDB-GENE-110408-21	Length:	746	Species:	Danio rerio

Alignment Length:	728	Identity:	312/728 - (42%)
Similarity:	406/728 - (55%)	Gaps:	141/728 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 GTSRQLFRDAAMAHG-GQETTSLLQQELNNIAATQTPASKLRSASSTLDASISRNPSTTGGKHEK 136
            |....|..||....| |.|... ::..|.....::.|:|...|:|..                ||
Zfish     7 GGCSALAEDADAVLGCGMEPAE-IEAALKKTCLSEMPSSSCHSSSGP----------------EK 54

  Fly   137 KLGHRRVAEGGEVTYKKIQSKQIMGSIQLGIQHTVGSLASKPKRDLLMNDFWEMETISFPPDGSS 201
            |:|||||...||.||||..|..:.|:|||||.:|||:|:|||:||:||.||:.:|:|.||.:||:
Zfish    55 KIGHRRVDASGETTYKKTTSSALKGAIQLGIGYTVGNLSSKPERDVLMQDFYVVESIFFPSEGSN 119

  Fly   202 ITPAHHYNDFRFKVYAPIAFRYFRDLFGIAPDDFLMSMCASPLRELSNPGASGSIFYLTTDDEFI 266
            :||||||.|||||.|||:||||||:||||.|||:|.|:|..||.|||||||||||||:|.|||||
Zfish   120 LTPAHHYPDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCNEPLIELSNPGASGSIFYVTRDDEFI 184

  Fly   267 IKTVQKKECEFLQKLLPGYYMNLSQNPRTLLPKFFGLYCFHYNSKNVRLVAMNNLLPSDIKMHCK 331
            :|||..||.||||||||||||||:|||||||||||||||.....||:|:|.|||:||...:||.|
Zfish   185 LKTVMHKEAEFLQKLLPGYYMNLNQNPRTLLPKFFGLYCVQSGGKNIRIVVMNNVLPRVFRMHLK 249

  Fly   332 YDLKGSSFRRKASKAERQKASPTFKDLDFAEHHPNGIFLETDKYNALMSTIKRDCMVLESFQIMD 396
            :|||||:::|:|||.||:|..||:|||||.:...:|:.|:.|.||||:.|::|||:|||||:|||
Zfish   250 FDLKGSTYKRRASKKEREKNRPTYKDLDFMQDVQDGLLLDVDTYNALLKTLQRDCLVLESFKIMD 314

  Fly   397 YSLLVGIHNLDLAAKEKREERILNARAKLQRKESAAQGPPSLNPDDDAPEADQNQLQAVASYASI 461
            ||||:|:||::.|.:|::.|              .:||     .|:..|.|
Zfish   315 YSLLLGVHNVEQAERERQME--------------GSQG-----SDEKRPAA-------------- 346

  Fly   462 PGTSAGAALNRTRSMNRQRLVAHSTALESITADMDVPLEEDEDVPAGGIPARSENDERLILYIGI 526
                             ||.: :|||:|||..........|.|...|||||.|...|||:|:|||
Zfish   347 -----------------QRAL-YSTAMESIQGGAACGDSIDTDDTMGGIPAVSGKGERLLLFIGI 393

  Fly   527 IDILQSYRLEKKLEHTFKSILYNGDTVSVCRPSFYAKRFQDAMGKQVFKKTPTFPLKHSPSKR-- 589
            |||||||||.||||||:|:::::||||||.||:|||.||...|...||||:.:  ||.||:|:
Zfish   394 IDILQSYRLIKKLEHTWKALVHDGDTVSVHRPNFYADRFFRFMSANVFKKSTS--LKASPAKKGR 456

  Fly   590 ------KTSTTQLRSPASRLPP-----LSTPTNAVRQPIMTMSGM-STPPPAFDDISEEDITAAS 642
                  |.|.......||:||.     :.....|...|::...|: |..||:|::        |:
Zfish   457 SVLAVPKFSVPGAAWSASQLPSERDENIYDLRGARSFPVLENDGLQSCTPPSFEE--------AT 513

  Fly   643 TSSLQQQRSSNQSNNNRGETEVALREGNNTRGGSGEPSSTYHTQYSYDSSGRTGSAL-------- 699
            |:|:....|||.|      ..:..|..::|   |..|....||....|:.|||...:
Zfish   514 TASVATTLSSNTS------ISIPERSPSDT---SEHPRYRRHTLSLKDAEGRTHEVVDVHEEDQQ 569

  Fly   700 -----------TSDYSDDESTGTDLSSRLPKLRTHRLTKTSVQVTTVGYVEGVDTPPKGGQDVVH 753
                       |.:..||..  ||.|      :||...:|.:...|    |.|..||
Zfish   570 TITVQVEVKRETEEDEDDRE--TDAS------QTHTDPETHIAAET----EMVPPPP-------- 614

  Fly   754 ADVNGKTTMTTTT 766
            ||.:....:.|.|
Zfish   615 ADSDPADDLETQT 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sktl	NP_001286646.1	PIPKc	183..573	CDD:214623	213/389 (55%)
pip5k1cb	XP_005171520.1	PIPKc	101..441	CDD:214623	213/390 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	372	1.000	Domainoid score	I849
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	532	1.000	Inparanoid score	I1176
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1562683at2759
OrthoFinder	1	1.000	-	-		FOG0000462
OrthoInspector	1	1.000	-	-		mtm6440
orthoMCL	1	0.900	-	-		OOG6_100438
Panther	1	1.100	-	-	O	PTHR23086
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X284
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.970