DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment insc and INSC

DIOPT Version :9

Sequence 1:	NP_477024.1	Gene:	insc / 37355	FlyBaseID:	FBgn0011674	Length:	859	Species:	Drosophila melanogaster
Sequence 2:	NP_001027024.3	Gene:	INSC / 387755	HGNCID:	33116	Length:	579	Species:	Homo sapiens

Alignment Length:	499	Identity:	116/499 - (23%)
Similarity:	197/499 - (39%)	Gaps:	101/499 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   308 EPVASWMSEQRWAGEPEVMCTLQHKSIAQE---------------------AYKNYTITTSAVCK 351
            :.|..||.:.:...|.|.||.||.|.|:.|                     ..|...:.::.:.:
Human    73 DSVQRWMEDLKLMTECECMCVLQAKPISLEEDAQGDLILAGGPGPGDPLQLLLKRGWVISTELRR 137

  Fly   352 LVRQLQQ--------QALSLQVHFERSERVLSGLQASSLPEALAGATQLLSHLDDFTATLERRGV 408
            :.::|.|        .::.|..|........|.:..:||.|.......|:....:.:|..||
Human   138 IGQKLAQDRWARVHSMSVRLTCHARSMVSEYSAVSRNSLKEMGEIEKLLMEKCSELSAVTER--- 199

  Fly   409 FFNDAKIERRRYEQHLEQIRTVSKDTRYSLERQHYINLESLLDDVQLLKRHTLITLRLIFERLVR 473
               ..::|.   |..|:.::....:| .|:..||:..|                 |.|...|.|:
Human   200 ---CLQVEN---EHVLKSMKACVSET-LSMLGQHFGQL-----------------LELALTREVQ 240

  Fly   474 VLVISIEQSQCDLLLRANI----NMVATLMNIDYDGFASLSDAFVQNEAVRTLLVVVLDHKQSSV 534
            .||..|:.|.       ||    :....|.::..:| |.|.....:...|..|..|.   :|.|.
Human   241 ALVRKIDASD-------NIYTTESTTGNLFSLTQEG-APLCRIIAKEGGVVALFKVC---RQDSF 294

  Fly   535 RAL---ALRALATLCCAPQAINQLGSCGGIEIVRDILQVESAGERGAIERREAVSLLAQITAAWH 596
            |.|   |||.||::||..:.::||....|:..:.|||...|..|   ..|.||.:::||:|:...
Human   295 RCLYPQALRTLASICCVEEGVHQLEKVDGVLCLADILTDNSHSE---ATRAEAAAVVAQVTSPHL 356

  Fly   597 GSEHRVPGLRDCAESLVAGLAALLQPECCTQTLLLCAAALNNLSRMEATSHYSIMSNEAIFRLID 661
            .....:....:..|.:|..|..|.|.....:..||.:|||.|::..:..:...::...||..|::
Human   357 PVTQHLSSFLESMEEIVTALVKLCQEASSGEVFLLASAALANITFFDTMACEMLLQLNAIRVLLE 421

  Fly   662 TLEHQTCGTSVFLYEQIVGMLHNMSLNKKCHSHL--ANGV--IINFITSVYQTEFYQTYGSRAES 722
            ....:....:.:..:|||.:|.|||:.::|.|.:  .|||  |:..::...::      |:.||.
Human   422 ACSDKQRVDTPYTRDQIVTILANMSVLEQCASDIIQENGVQLIMGMLSEKPRS------GTPAEV 480

  Fly   723 DAQRRTIKTILHTLTRLASDSPTLGAELLEQWHLPDLLRQSLAL 766
            .|..|..:....||.||:.|              ||:.|:::.|
Human   481 AACERVQQKAAVTLARLSRD--------------PDVAREAVRL 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
insc	NP_477024.1	MSS4	<62..>142	CDD:227578
INSC	NP_001027024.3	INSC_LBD	70..113	CDD:293353	12/39 (31%)
		Important for interaction with GPSM2. /evidence=ECO:0000269\|PubMed:22074847	74..89		4/14 (29%)
		ARM	454..>562	CDD:237987	18/77 (23%)
		PDZ-binding	576..579
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155683
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28JIZ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I5241
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008516
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR21386
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3451
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.880