DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment insc and Insc

DIOPT Version :9

Sequence 1:	NP_477024.1	Gene:	insc / 37355	FlyBaseID:	FBgn0011674	Length:	859	Species:	Drosophila melanogaster
Sequence 2:	NP_001099755.1	Gene:	Insc / 293166	RGDID:	1311379	Length:	579	Species:	Rattus norvegicus

Alignment Length:	524	Identity:	122/524 - (23%)
Similarity:	197/524 - (37%)	Gaps:	151/524 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   308 EPVASWMSEQRWAGEPEVMCTLQHKSIAQEAYKNYTITTSAVCKLVRQLQQQALSLQVHFERSER 372
            :.|..||.:.:...|.|.||.||.|.|:.|                            ...:|:.
  Rat    73 DSVQRWMEDLKLMTECECMCVLQAKPISLE----------------------------EDTQSDL 109

  Fly   373 VLSGLQASSLPEALAGATQLLSHLDDFTATLERRGVFFNDAKIERRRYEQHLEQIR--------- 428
            :|:|......|      .|||         |:|..|.    ..|.||..|.|.|.|
  Rat   110 ILAGGPGPGDP------LQLL---------LKRGWVI----STELRRIGQKLAQDRWARVHSMSV 155

  Fly   429 --------------TVSKDTRYSL------------------------ERQHYI-NLESLLDD-V 453
                          |:|:.|...:                        |.:|.: ::::.:.: :
  Rat   156 RLTCHARSMVSEYSTISRTTSQEMGQAEKLLMEKCSELSAVTERCLQVENEHVLKSMKACVSETL 220

  Fly   454 QLLKRHTLITLRLIFERLVRVLVISIEQSQCDLLLRANI----NMVATLMNIDYDGFASLSDAFV 514
            .:|.:|....|.|...|.|:.||..|:.|.       ||    :....|.::..:| |.|.....
  Rat   221 SMLGQHFGQLLELALTREVQALVRKIDTSD-------NIYITESTTGNLFSLTQEG-APLCRIIA 277

  Fly   515 QNEAVRTLLVVVLDHKQSSVRAL---ALRALATLCCAPQAINQLGSCGGIEIVRDILQVESAGER 576
            :...|..|..|.   :|.:.|.|   |||.||::||..:.::||....||..:.|||..:|..|
  Rat   278 KEGGVVALFKVC---RQDTFRCLYPQALRTLASICCVEEGVHQLEKVDGILCLTDILTDDSHSE- 338

  Fly   577 GAIERREAVSLLAQITAAWHGSEHRVPGLRDCAESLVAGLAALLQPECCTQTLLLCAAALNNLSR 641
              ..|.||.:::||:|:........:....:..|.:|..|..|.|.....:..||.:|||.|::.
  Rat   339 --ATRAEAAAVVAQVTSPHLSFTQHLTSFLENMEEIVTALIKLCQEASSGEVFLLASAALANITF 401

  Fly   642 MEATSHYSIMSNEAIFRLIDTLEHQTCG-----TSVFLYEQIVGMLHNMSLNKKCHSHL--ANGV 699
            .|..:...::...||..|:     :.||     .:.:..:|||.:|.|||:.::|.|.:  .|||
  Rat   402 FEKMACEMLLQLNAIRVLL-----EACGDKQRVDTPYTRDQIVTILANMSVLEQCASDIIQENGV 461

  Fly   700 --IINFITSVYQTEFYQTYGSRAESDAQRRTIKTILHTLTRLASDSPTLGAELLEQWHLPDLLRQ 762
              |:..::...::      |:.||..|..|..:....||.||..|              ||:.|:
  Rat   462 QLIMGMLSEKPRS------GTPAEVAACERVQQKAAVTLARLCRD--------------PDVARE 506

  Fly   763 SLAL 766
            ::.|
  Rat   507 AVRL 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
insc	NP_477024.1	MSS4	<62..>142	CDD:227578
Insc	NP_001099755.1	INSC_LBD	70..113	CDD:407017	14/67 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349588
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28JIZ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	77	1.000	Inparanoid score	I5158
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008516
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR21386
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.850