Protein Alignment KARS1 and LysRS

DIOPT Version :10

• Sequence 1: NP_001123561.1
• Gene: KARS1 / 3735
• HGNCID: 6215
• Length: 625
• Species: Homo sapiens
• Sequence 2: NP_727353.1
• Gene: LysRS / 31904
• FlyBaseID: FBgn0027084
• Length: 607
• Species: Drosophila melanogaster
• Alignment Length: 617
• Identity: 406/617 - (65%)
• Similarity: 481/617 - (77%)
• Gaps: 20/617 - (3%)

Human     1 MLTQAAVRLVRGSLRKTSWAEWGHRELRLGQLAPFTAPHKDKSFSDQRSELKRRLKAEKKVAEKE 65
            |..:.|:|.|:||..:..:.  |.:.|..|  ...:||..:.| ...:.|||||||||:|..||.
  Fly     1 MFARCALRTVQGSWPRCRYT--GIQPLAAG--FHVSAPQMEPS-KQTKLELKRRLKAEQKAKEKA 60

Human    66 AKQKELSEKQLSQATAAATNHTT--DNGVGPEEESVDPNQYYKIRSQAIHQLKVN-GEDPYPHKF 127
            .|           |.||...:|.  ......|||.:.||:|:|:||.|:.:||.: ..|||||||
  Fly    61 EK-----------AAAAPAENTAGKKKSSAAEEEEISPNEYFKLRSAAVQELKRSPATDPYPHKF 114

Human   128 HVDISLTDFIQKYSH-LQPGDHLTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNY 191
            ||..||.|||.||.: |:.|:.|.::.|.||||:||.|.||.|||||||||||||:||||::::|
  Fly   115 HVSSSLEDFIAKYENSLKEGETLENVKLSVAGRVHAIRESGAKLIFYDLRGEGVKVQVMASAKSY 179

Human   192 KSEEEFIHINNKLRRGDIIGVQGNPGKTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYR 256
            |||.:|....:||||||||||.|:||||||||||::|.||.||||||||||||||||||||||||
  Fly   180 KSEADFEIDTSKLRRGDIIGVVGHPGKTKKGELSVMPSEIKLLSPCLHMLPHLHFGLKDKETRYR 244

Human   257 QRYLDLILNDFVRQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMN 321
            |||||||||:.||:||.||:|||:|:|.|||.||||||||||||:|.|||.||||:|:||:|.|:
  Fly   245 QRYLDLILNNNVREKFQIRAKIISYVRQFLDRLGFLEIETPMMNMIAGGATAKPFVTHHNDLKMD 309

Human   322 LYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMV 386
            |:||||||||||||||||:|||||||||||||||||||||||||||||||||||.|:|:|||::|
  Fly   310 LFMRIAPELYHKMLVVGGLDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYADIMDITEQLV 374

Human   387 SGMVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETRKIL 451
            |||||.|.|||||.|||:||||...::||||||:|::|::.||:.|.:|.|..:.|.:.||.:.|
  Fly   375 SGMVKAIRGSYKVIYHPEGPEGPEQELDFTPPFKRVSMIKTLEEKLQVKFPAADTFNSPETNQFL 439

Human   452 DDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKEGLTERFEL 516
            ..:|....||||.|||||||||||||||:|..|:||||||:||||||||||:|||..||||||||
  Fly   440 SQLCAKHQVECPAPRTTARLLDKLVGEFIEEFCVNPTFICEHPQIMSPLAKYHRSIPGLTERFEL 504

Human   517 FVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYGLPPTAGWGMGIDR 581
            ||.||||||||||||||:.||:.||:||..||||||||..:||||||:||||||||.|:||||||
  Fly   505 FVAKKEICNAYTELNDPVVQRERFEQQASDKAAGDDEAQLVDENFCTSLEYGLPPTGGFGMGIDR 569

Human   582 VAMFLTDSNNIKEVLLFPAMKPEDKKENVATT 613
            :|||||||||||||||||||||||.....|.|
  Fly   570 LAMFLTDSNNIKEVLLFPAMKPEDANRTAAET 601

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KARS1	NP_001123561.1	PLN02502	48..605	CDD:215278	390/560 (70%)
LysRS	NP_727353.1	PLN02502	42..593	CDD:215278	390/561 (70%)