DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13442 and MARCHF4

DIOPT Version :9

Sequence 1:	NP_611511.3	Gene:	CG13442 / 37349	FlyBaseID:	FBgn0034546	Length:	425	Species:	Drosophila melanogaster
Sequence 2:	NP_065865.1	Gene:	MARCHF4 / 57574	HGNCID:	29269	Length:	410	Species:	Homo sapiens

Alignment Length:	413	Identity:	94/413 - (22%)
Similarity:	137/413 - (33%)	Gaps:	143/413 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 SDLK-------PETTLEMEIDEALSSSSADDTPPGMIVVET-------RISSWQKVKCYDKDGTT 74
            :|||       |:..|.|.         .|..|||:....|       ..:.|:..:      ..
Human    47 NDLKVFLLRRPPQAPLPMH---------GDPQPPGLAANNTLPALGAGGWAGWRGPR------EV 96

  Fly    75 ADAEDPQIPACSLGLKPNVQFQKLPHPSHPLVSTEAVLAAATSSSYSAGPPKAAATDSIATLRHC 139
            ...|.|.:|               |.|..|..|.|         ....||    ||:..|:|...
Human    97 VGREPPPVP---------------PPPPLPPSSVE---------DDWGGP----ATEPPASLLSS 133

  Fly   140 VDGATQCNNLNYESASNESMPSVGSL--------VCRICHNADNPEQLVSPCLCKGSLTYVHVHC 196
            ......|..      ..|...|:||.        :||||.......:|:|||.|.||:...|..|
Human   134 ASSDDFCKE------KTEDRYSLGSSLDSGMRTPLCRICFQGPEQGELLSPCRCDGSVKCTHQPC 192

  Fly   197 LECWISTSRCTTCELCQFQYNTEQTLRYTCLQSLRLWYSRAMSRRALQEDCQMFSLLTLVAFGII 261
            |..|||...|.:||||.::|:.........||    |  :|:|...:::        ..||..|:
Human   193 LIKWISERGCWSCELCYYKYHVIAISTKNPLQ----W--QAISLTVIEK--------VQVAAAIL 243

  Fly   262 GTLLVGIQYYALHTHSWGL------SKLWTKSWMLF------FLFMTITVY------FANIYMLI 308
            |:|      :.:.:.||.:      |..|.:..:||      :.||.:...      ..::|.:.
Human   244 GSL------FLIASISWLIWSTFSPSARWQRQDLLFQICYGMYGFMDVVCIGLIIHEGPSVYRIF 302

  Fly   309 KSQLTPWYRWWQSARDIKLILENRRPFPNPSRFLRSFQLETVSTTASMYTHHDQQEA----PVPS 369
            |.        ||:......:|          .:.::..||            ||:..    |..|
Human   303 KR--------WQAVNQQWKVL----------NYDKTKDLE------------DQKAGGRTNPRTS 337

  Fly   370 SSPVIVITSSEEETEDKLAHKWG 392
            ||....|.||||||....|.:.|
Human   338 SSTQANIPSSEEETAGTPAPEQG 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13442	NP_611511.3	AmyAc_family	<36..>151	CDD:298606	21/121 (17%)
CG13442	NP_611511.3	RINGv	166..213	CDD:128983	21/46 (46%)
MARCHF4	NP_065865.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	92..136		14/77 (18%)
		RINGv	163..208	CDD:128983	20/44 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	324..372		16/49 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	390..410
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5183
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810