DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13442 and MARCHF11

DIOPT Version :9

Sequence 1:	NP_611511.3	Gene:	CG13442 / 37349	FlyBaseID:	FBgn0034546	Length:	425	Species:	Drosophila melanogaster
Sequence 2:	NP_001096032.1	Gene:	MARCHF11 / 441061	HGNCID:	33609	Length:	402	Species:	Homo sapiens

Alignment Length:	299	Identity:	70/299 - (23%)
Similarity:	111/299 - (37%)	Gaps:	88/299 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 KLPHPSHPLVSTEAVLAAATSSSYSAGP---PKAAA--------------------------TDS 132
            :||.|..||......:|||..|  ..||   |:|||                          |.|
Human    81 ELPPPPLPLQPAGQEVAAAGDS--GEGPRRLPEAAAAKGGPGESEAGAGGERERRGAGDQPETRS 143

  Fly   133 IATLRHCVDGATQCNNLNYESASNESMPSVGSLVCRICHNADNPEQLVSPCLCKGSLTYVHVHCL 197
            :.:.|....|... ....::...::.       :|:||.......:|::||.|.||:.|.|..||
Human   144 VCSSRSSSSGGGD-QRAGHQHQHHQP-------ICKICFQGAEQGELLNPCRCDGSVRYTHQLCL 200

  Fly   198 ECWISTSRCTTCELCQFQYNT-EQTLRYTCLQSLRLWYSRAMSRRALQEDCQMFSLLTLVAFGII 261
            ..|||.....|||||.::|:. ...::..|     .|.|.:::   |.|..||.::       |:
Human   201 LKWISERGSWTCELCCYRYHVIAIKMKQPC-----QWQSISIT---LVEKVQMIAV-------IL 250

  Fly   262 GTLLVGIQYYALHTHSWGLSKLWTKSWMLF------FLFMTITVY------FANIYMLIKSQLTP 314
            |:|.:......|...::....:|.:..:||      :.||.:...      .|.:|.:.|
Human   251 GSLFLIASVTWLLWSAFSPYAVWQRKDILFQICYGMYGFMDLVCIGLIVHEGAAVYRVFK----- 310

  Fly   315 WYRW-----------WQSARDIKLILENRRPFPNPSRFL 342
              ||           :..|.||:   |:.|...:.||.|
Human   311 --RWRAVNLHWDVLNYDKATDIE---ESSRGESSTSRTL 344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13442	NP_611511.3	AmyAc_family	<36..>151	CDD:298606	19/82 (23%)
CG13442	NP_611511.3	RINGv	166..213	CDD:128983	20/46 (43%)
MARCHF11	NP_001096032.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..161		19/82 (23%)
		RINGv	169..215	CDD:128983	19/45 (42%)
		YXXL motif	371..374
		PDZ-binding	399..402
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5183
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810