DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fem-1 and FEM1B

DIOPT Version :9

Sequence 1:	NP_611508.1	Gene:	Fem-1 / 37344	FlyBaseID:	FBgn0034542	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_056137.1	Gene:	FEM1B / 10116	HGNCID:	3649	Length:	627	Species:	Homo sapiens

Alignment Length:	643	Identity:	259/643 - (40%)
Similarity:	369/643 - (57%)	Gaps:	31/643 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 LHLAARSGQMLSFVEILNSVSCRAVQTHLVNTNFDQPDGQSLTPLTMAAMMGNVKFVKTLLSHYD 125
            ::.||..|::|:...:|.:.|...::..|...:  |..||..|||.:||..|:.|.|:.||.||.
Human     8 VYKAASEGKVLTLAALLLNRSESDIRYLLGYVS--QQGGQRSTPLIIAARNGHAKVVRLLLEHYR 70

  Fly   126 VDLDRECNVIYDGMVVYGATALWVAAGMGHLQIVKMLVQAGAAINHNTKAQSSPLRAACYEGRLD 190
            |...:...|.:||.|:.||||||.|||.||.::||:||..||.:||.|...|:||||||::||||
Human    71 VQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLD 135

  Fly   191 IVEFLIDNGADVNATNLFNNNTLMIAAYKGHHLVVKTLLQNGSRANDQALCGATALHYAAESGHL 255
            ||::|::|.|:::..|.::|..|||||||||..||:.||:..:..|.:|.|||||||:|||:||:
Human   136 IVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHI 200

  Fly   256 DVVVALLDHGATLKKNELGITPALQAAERLHEDVLEAFIERPELMSLEEQITALELLGATYANDK 320
            |:|..|:...|.:..|..|:||...|||....||:|..:...: .....:|.|||||||::|||:
Human   201 DIVKELIKWRAAIVVNGHGMTPLKVAAESCKADVVELLLSHAD-CDRRSRIEALELLGASFANDR 264

  Fly   321 IKYDVNKAYGYLLRAMQLRYSNPRGVIRKRVQPTVPAYDNWLETENLPELYAIKLNHHSIHMESL 385
            ..||:.|.|.||..||..|:.:...::.|.|.|.:.||.|..|..|..||.:|:.:..::|||.|
Human   265 ENYDIIKTYHYLYLAMLERFQDGDNILEKEVLPPIHAYGNRTECRNPQELESIRQDRDALHMEGL 329

  Fly   386 AIRERILGRNNPELPQAIIYRGAVMADQGRFYQCQVLWNYAIDLRMRNNVSVDRDLLRFAQLFAQ 450
            .:||||||.:|.::...|||||||.||...|.||..||.:|:.||.:.|.:..:|||||||:|:|
Human   330 IVRERILGADNIDVSHPIIYRGAVYADNMEFEQCIKLWLHALHLRQKGNRNTHKDLLRFAQVFSQ 394

  Fly   451 ILRVENHNLTLDHVLPVLAKCQQEIENNKFKIKEAKP----NACPSLWQDQNNQNCITALYLIKI 511
            ::.: |..:....:..||.....|||.:..::|....    ||     .|....|..|.|||:.|
Human   395 MIHL-NETVKAPDIECVLRCSVLEIEQSMNRVKNISDADVHNA-----MDNYECNLYTFLYLVCI 453

  Fly   512 VTHLARRKKDQNIDEEHIQQLFLVVRKFIQNDTRLQDGQTLLHIAVNGVMPVDEFYTNEMCRFPC 576
            .|.....::||....:.|..|       |..|.|.::|.||||:|||...|||:|:||::|.||.
Human   454 STKTQCSEEDQCKINKQIYNL-------IHLDPRTREGFTLLHLAVNSNTPVDDFHTNDVCSFPN 511

  Fly   577 YATALVLVHCGASVVAVDSDRNTPLHILVTKVNTTQDRQAEMARILELFVEAGAHLDAVNAAGQT 641
            .....:|:.|||.|.|||::.|:.|||:|.......|.....:.|:.| ||||||.|..|...:|
Human   512 ALVTKLLLDCGAEVNAVDNEGNSALHIIVQYNRPISDFLTLHSIIISL-VEAGAHTDMTNKQNKT 575

  Fly   642 ----AATACKLPILANRLHAHQNAHTSLKCLAARSIATNRLNFKGLIPTQLEAFIQMH 695
                :.|.....:|..::      ..||||||||::..|.:|::..||..||.|:..|
Human   576 PLDKSTTGVSEILLKTQM------KMSLKCLAARAVRANDINYQDQIPRTLEEFVGFH 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fem-1	NP_611508.1	ANK	61..196	CDD:238125	60/134 (45%)
		ANK repeat	103..129	CDD:293786	13/25 (52%)
		Ank_2	105..206	CDD:289560	51/100 (51%)
		ANK	142..262	CDD:238125	67/119 (56%)
		ANK repeat	142..173	CDD:293786	19/30 (63%)
		ANK repeat	178..206	CDD:293786	15/27 (56%)
		Ank_2	180..266	CDD:289560	46/85 (54%)
		ANK repeat	208..239	CDD:293786	15/30 (50%)
		ANK repeat	241..266	CDD:293786	15/24 (63%)
		Ank_4	244..294	CDD:290365	23/49 (47%)
		ANK	548..685	CDD:238125	54/140 (39%)
		ANK repeat	548..594	CDD:293786	23/45 (51%)
		ANK repeat	596..636	CDD:293786	15/39 (38%)
FEM1B	NP_056137.1	Ank_2	11..117	CDD:403870	45/107 (42%)
		ANK 1	45..74		14/28 (50%)
		ANK repeat	48..85	CDD:293786	16/36 (44%)
		ANK repeat	87..118	CDD:293786	19/30 (63%)
		ANK 2	87..116		17/28 (61%)
		Ank_2	92..183	CDD:403870	48/90 (53%)
		ANK repeat	120..151	CDD:293786	16/30 (53%)
		ANK 3	120..149		16/28 (57%)
		ANK repeat	153..183	CDD:293786	15/29 (52%)
		ANK 4	153..182		14/28 (50%)
		Ank_2	158..247	CDD:403870	41/89 (46%)
		ANK 5	186..215		16/28 (57%)
		ANK repeat	186..211	CDD:293786	15/24 (63%)
		ANK 6	218..248		9/30 (30%)
		ANK repeat	218..247	CDD:293786	9/29 (31%)
		TPR	344..377		17/32 (53%)
		PHA03095	475..>613	CDD:222980	57/144 (40%)
		ANK repeat	483..529	CDD:293786	23/45 (51%)
		ANK 7	483..527		22/43 (51%)
		ANK repeat	531..570	CDD:293786	15/39 (38%)
		ANK 8	531..568		14/37 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159012
Domainoid	1	1.000	146	1.000	Domainoid score	I4568
eggNOG	1	0.900	-	-		E2759_KOG0508
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H7714
Inparanoid	1	1.050	426	1.000	Inparanoid score	I1756
Isobase	1	0.950	-	0	Normalized mean entropy	S3789
OMA	1	1.010	-	-		QHG49484
OrthoDB	1	1.010	-	-		D133963at33208
OrthoFinder	1	1.000	-	-		FOG0008196
OrthoInspector	1	1.000	-	-		oto91596
orthoMCL	1	0.900	-	-		OOG6_108967
Panther	1	1.100	-	-	LDO	PTHR24173
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4569
SonicParanoid	1	1.000	-	-		X856
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.750