DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fem-1 and fem1c

DIOPT Version :9

Sequence 1:	NP_611508.1	Gene:	Fem-1 / 37344	FlyBaseID:	FBgn0034542	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	XP_002931764.1	Gene:	fem1c / 100493200	XenbaseID:	XB-GENE-998529	Length:	617	Species:	Xenopus tropicalis

Alignment Length:	651	Identity:	224/651 - (34%)
Similarity:	349/651 - (53%)	Gaps:	63/651 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 AARSGQMLSFVEIL-NSVSCRAVQTHLVNTNFDQPDGQSLTPLTMAAMMGNVKFVKTLLSHYDVD 127
            |||.|::....::| |......|......||       ..|||.|||..|::..|..||......
Frog    10 AARDGKLRLLSKLLENKAKDEVVVLMSEKTN-------GATPLLMAARYGHLDMVDYLLDQCSAS 67

  Fly   128 LDRECNVIYDGMVVYGATALWVAAGMGHLQIVKMLVQAGAAINHNTKAQSSPLRAACYEGRLDIV 192
            ::...:|.:||..:.||..||.|:..|||::|:.|:..||::|:.|...|:||||||::|.|:||
Frog    68 VEIGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLDHGASVNNTTLTNSTPLRAACFDGHLEIV 132

  Fly   193 EFLIDNGADVNATNLFNNNTLMIAAYKGHHLVVKTLLQNGSRANDQALCGATALHYAAESGHLDV 257
            ::|:::.||:...|...:..|||:.||||..:.:.||:.|:..|.:::.|.||||..||||.|::
Frog   133 KYLVEHKADLEVANRHGHTCLMISCYKGHKEIAQFLLEKGADVNRKSVKGNTALHDCAESGSLEI 197

  Fly   258 VVALLDHGATLKKNELGITPALQAAERLHEDVLEAFIERPELMSLEEQITALELLGATYANDKIK 322
            :..||.:||.::|:..|:||.|.|:...|.::::...:.|:...: |:|.||||||||:. || |
Frog   198 MQMLLKYGARMEKDGYGMTPLLSASVTGHTNIVDFLTQHPQTSKI-ERINALELLGATFV-DK-K 259

  Fly   323 YDVNKAYGYLLRAMQLRYSNPRGVIRK-RVQPTVPAYDNWLETENLPELYAIKLNHHSIHMESLA 386
            .|:..|..|..|||.:|||:...:|.| ..|..:.|||...|.....||..:..:...:.|::|.
Frog   260 RDLLGALKYWKRAMDMRYSDRTNIISKPEPQTLIMAYDYAREVNTAEELDNLIADPDEMRMQALL 324

  Fly   387 IRERILGRNNPELPQAIIYRGAVMADQGRFYQCQVLWNYAIDLRMRN----NVSVDRDLLRFAQL 447
            |||||||.::|:....|.|||||.||.|.|.:|..||.||:|::..|    :......||.||:|
Frog   325 IRERILGPSHPDTSYYIRYRGAVYADSGNFKRCINLWKYALDMQQNNLDPLSPMTASSLLSFAEL 389

  Fly   448 FAQILRVENHNL-----TLDHVLPVLAKCQQEIENNKFKIKEAKPNACPSLWQDQNNQNCITALY 507
            |:.:|:.....|     |.|.::.:|.|...||:.   .:|:..|.  |.  |.|.|:.....|:
Frog   390 FSFMLQDRAKGLLGTTVTFDDLMGILCKSVMEIDR---AVKQTAPP--PD--QVQLNKALSIILH 447

  Fly   508 LIKIVTHLARRKKDQNIDEEHI--QQLFLVVRKFIQNDTRLQDGQTLLHIAVN------GVMPVD 564
            ||.::     .|...:.|:||.  |.::    :|::...:.::..:.||:||:      |..||
Frog   448 LICLL-----EKVPCSPDQEHFKKQNIY----RFLKLHPKGKNNFSPLHLAVDKNTTCVGRYPV- 502

  Fly   565 EFYTNEMCRFPCYATALVLVHCGASVVAVDSDRNTPLHILVTKVNTTQDRQAEMARILELFVEAG 629
                   |:||.:....:|:.|||.|...|:::|:||||  ..:|...|       |:.|.|::|
Frog   503 -------CKFPSFQVTAILLECGADVNVRDAEQNSPLHI--AALNNHPD-------IMNLLVKSG 551

  Fly   630 AHLDAVNAAGQTAATACKLPILANRLHAHQNAHTSLKCLAARSIATNRLNFKGLIPTQLEAFIQM 694
            ||.|:.|:..|||........:|..|....| ||:|:|||||.|..:.:.:|..||.:||:|:.:
Frog   552 AHFDSTNSHNQTACDLLDEKEMAKNLIQPIN-HTTLQCLAARVIVKHNIQYKQEIPEKLESFVLL 615

  Fly   695 H 695
            |
Frog   616 H 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fem-1	NP_611508.1	ANK	61..196	CDD:238125	47/132 (36%)
		ANK repeat	103..129	CDD:293786	10/25 (40%)
		Ank_2	105..206	CDD:289560	39/100 (39%)
		ANK	142..262	CDD:238125	50/119 (42%)
		ANK repeat	142..173	CDD:293786	13/30 (43%)
		ANK repeat	178..206	CDD:293786	13/27 (48%)
		Ank_2	180..266	CDD:289560	36/85 (42%)
		ANK repeat	208..239	CDD:293786	11/30 (37%)
		ANK repeat	241..266	CDD:293786	12/24 (50%)
		Ank_4	244..294	CDD:290365	20/49 (41%)
		ANK	548..685	CDD:238125	47/142 (33%)
		ANK repeat	548..594	CDD:293786	15/51 (29%)
		ANK repeat	596..636	CDD:293786	14/39 (36%)
fem1c	XP_002931764.1	ANK repeat	5..38	CDD:293786	7/27 (26%)
		Ank_2	10..110	CDD:372319	34/106 (32%)
		ANK repeat	40..75	CDD:293786	11/41 (27%)
		ANK repeat	82..113	CDD:293786	13/30 (43%)
		Ank_2	87..178	CDD:372319	38/90 (42%)
		ANK repeat	118..146	CDD:293786	13/27 (48%)
		ANK repeat	148..179	CDD:293786	11/30 (37%)
		Ank_2	153..236	CDD:372319	32/82 (39%)
		PHA02876	<164..>554	CDD:165207	141/425 (33%)
		ANK repeat	181..209	CDD:293786	14/27 (52%)
		ANKYR	<457..599	CDD:223738	51/163 (31%)
		ANK repeat	481..525	CDD:293786	15/51 (29%)
		ANK repeat	527..552	CDD:293786	10/33 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D133963at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X856
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920