DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lrt and CYR1

DIOPT Version :9

Sequence 1:NP_001286640.1 Gene:Lrt / 37342 FlyBaseID:FBgn0034540 Length:830 Species:Drosophila melanogaster
Sequence 2:NP_012529.3 Gene:CYR1 / 853452 SGDID:S000003542 Length:2026 Species:Saccharomyces cerevisiae


Alignment Length:783 Identity:180/783 - (22%)
Similarity:281/783 - (35%) Gaps:217/783 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 FKFRTLIKRTSPIMRPKLSAILM---LLLL--------CTLAAANDL----KDLLEDSTTSSSTS 59
            |:....:.:.|.|:||....||:   ||||        ..:....||    |.|....|.|..|.
Yeast   719 FQISLKVGKLSKILRPTSKPILIERKLLLLNGYRKSDPLHIMGIEDLSFVFKFLFHPVTPSHFTP 783

  Fly    60 TTSSTIPSS-----------VTSPTTPTAYVVSAAAVPALVAGRGKS------------KSTSGK 101
            .....|..|           :|:|  |..:....:.:.:|......:            |..|.:
Yeast   784 EQEQRIMRSEFVHVDLRNMDLTTP--PIIFYQHTSEIESLDVSNNANIFLPLEFIESSIKLLSLR 846

  Fly   102 YVN----KSSPRKRKAEQVSSLPL------PVDDALMEWKCPNITGTRNAELECGCDLPHTLRCN 156
            .||    |......||.::.||.|      .|.:::|  |..|:|..             .|:||
Yeast   847 MVNIRASKFPSNITKAYKLVSLELQRNFIRKVPNSIM--KLSNLTIL-------------NLQCN 896

  Fly   157 ---------IDLHGMMLL---ADRLRTSP----YSISLL--DCSLRNVTFLSDAKIFDNVSLHGL 203
                     ::|..:.||   :::....|    |..:||  |.|...:..|..:..:        
Yeast   897 ELESLPAGFVELKNLQLLDLSSNKFMHYPEVINYCTNLLQIDLSYNKIQSLPQSTKY-------- 953

  Fly   204 VISSGEIKRVH-KSAFLGIRG---PLQALGLPGNALMSVPWNALS----------------TLSA 248
            ::...::...| |..|:|...   .|:.|.|..|.:.|:..||.:                ||..
Yeast   954 LVKLAKMNLSHNKLNFIGDLSEMTDLRTLNLRYNRISSIKTNASNLQNLFLTDNRISNFEDTLPK 1018

  Fly   249 LERLDLANNKIKALGTADFV--GLTSLVYLELSNNQISSISQRTFVNLRKLEVLKLGGNRLGDYA 311
            |..|::..|.|.::...||.  .:|||.   |:..|:|||.......|..||.|:|..|.|....
Yeast  1019 LRALEIQENPITSISFKDFYPKNMTSLT---LNKAQLSSIPGELLTKLSFLEKLELNQNNLTRLP 1080

  Fly   312 QSLR--------------------SLSQCLSLRQLDLQANNLNGPLSEQTLPGMRNLE--SLNLN 354
            |.:.                    .|||..|||.|||.:||:     ...:.||.|||  |||::
Yeast  1081 QEISKLTKLVFLSVARNKLEYIPPELSQLKSLRTLDLHSNNI-----RDFVDGMENLELTSLNIS 1140

  Fly   355 RNLI--KSIQNKALANFS-------RLVSLSLRHNQIDVLQDHAFFGLGALDSLDLSYNGIVAIS 410
            .|..  .|::|....|.|       .|:......||.|......|.....|..|:||||.   .|
Yeast  1141 SNAFGNSSLENSFYHNMSYGSKLSKSLMFFIAADNQFDDAMWPLFNCFVNLKVLNLSYNN---FS 1202

  Fly   411 SASLQHLSRLTVLDLTHNFLRALTSDLIAPLPSLRELRLAGND-ISIVARNAMDGARELESLQMQ 474
            ..|...|..:|.|.|:.|.|..|:.|.:....||:.|.|..|. :|:.|.  :....:|....:.
Yeast  1203 DVSHMKLESITELYLSGNKLTTLSGDTVLKWSSLKTLMLNSNQMLSLPAE--LSNLSQLSVFDVG 1265

  Fly   475 ENPLSCDCSIRPFA-EWLQESQL---------------------HSSLSASCVTPPRLEGAPLLQ 517
            .|.|..:.|...:. .|....:|                     .:.||...|. |:|:...|:.
Yeast  1266 ANQLKYNISNYHYDWNWRNNKELKYLNFSGNRRFEIKSFISHDIDADLSDLTVL-PQLKVLGLMD 1329

  Fly   518 VPVETLSCDMDNVE---KDNANIMQHL-----ETLAKPNQTSPIKDLSEE----------IILHE 564
            |.:.|.....:||.   :..|:|:..:     :||.:.:..|. :|::.|          :.||:
Yeast  1330 VTLNTTKVPDENVNFRLRTTASIINGMRYGVADTLGQRDYVSS-RDVTFERFRGNDDECLLCLHD 1393

  Fly   565 -LHFSTDYGLILTWLLNLSK--KDYMCDAIFVYKEEHINEILIDNSPIHCE------SKVVNGQ- 619
             .:.:.|||      .|:|:  :| :.|.|.:.:.|...:...||......      :|.:||. 
Yeast  1394 SKNQNADYG------HNISRIVRD-IYDKILIRQLERYGDETDDNIKTALRFSFLQLNKEINGML 1451

  Fly   620 NTV 622
            |:|
Yeast  1452 NSV 1454

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LrtNP_001286640.1 LRR_RI <151..334 CDD:238064 59/242 (24%)
leucine-rich repeat 179..199 CDD:275378 4/21 (19%)
leucine-rich repeat 200..223 CDD:275380 4/23 (17%)
leucine-rich repeat 225..248 CDD:275380 9/38 (24%)
LRR_8 249..307 CDD:290566 20/59 (34%)
leucine-rich repeat 249..272 CDD:275380 6/24 (25%)
LRR_RI <270..479 CDD:238064 70/240 (29%)
leucine-rich repeat 273..296 CDD:275380 7/22 (32%)
leucine-rich repeat 297..322 CDD:275380 10/44 (23%)
LRR_8 322..382 CDD:290566 23/70 (33%)
leucine-rich repeat 323..347 CDD:275380 9/23 (39%)
leucine-rich repeat 348..371 CDD:275380 10/33 (30%)
LRR_8 370..428 CDD:290566 18/64 (28%)
leucine-rich repeat 372..395 CDD:275380 5/22 (23%)
leucine-rich repeat 396..419 CDD:275380 9/22 (41%)
LRR_8 418..478 CDD:290566 16/60 (27%)
leucine-rich repeat 420..443 CDD:275380 7/22 (32%)
leucine-rich repeat 444..467 CDD:275380 6/23 (26%)
LRRCT 476..526 CDD:214507 13/71 (18%)
CYR1NP_012529.3 Ad_cyc_g-alpha 368..418 CDD:369912
RA_PHLPP_like 678..776 CDD:340473 15/56 (27%)
PLN00113 792..>1273 CDD:215061 123/518 (24%)
leucine-rich repeat 796..817 CDD:275380 3/22 (14%)
leucine-rich repeat 818..839 CDD:275380 1/20 (5%)
leucine-rich repeat 840..864 CDD:275380 7/23 (30%)
leucine-rich repeat 865..887 CDD:275380 6/23 (26%)
leucine-rich repeat 888..910 CDD:275380 5/34 (15%)
leucine-rich repeat 911..933 CDD:275380 4/21 (19%)
leucine-rich repeat 934..956 CDD:275380 5/29 (17%)
leucine-rich repeat 957..978 CDD:275380 4/20 (20%)
leucine-rich repeat 979..1018 CDD:275380 9/38 (24%)
leucine-rich repeat 1019..1041 CDD:275380 6/21 (29%)
leucine-rich repeat 1042..1065 CDD:275380 9/25 (36%)
leucine-rich repeat 1066..1088 CDD:275380 7/21 (33%)
leucine-rich repeat 1089..1111 CDD:275380 3/21 (14%)
leucine-rich repeat 1167..1187 CDD:275380 5/19 (26%)
leucine-rich repeat 1191..1211 CDD:275380 9/22 (41%)
leucine-rich repeat 1236..1258 CDD:275380 6/23 (26%)
leucine-rich repeat 1259..1287 CDD:275380 5/27 (19%)
PP2C 1374..1617 CDD:395385 20/88 (23%)
CYCc 1613..1825 CDD:214485
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
00.000

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