DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lrt and islr2

DIOPT Version :9

Sequence 1:NP_001286640.1 Gene:Lrt / 37342 FlyBaseID:FBgn0034540 Length:830 Species:Drosophila melanogaster
Sequence 2:NP_001013541.1 Gene:islr2 / 541396 ZFINID:ZDB-GENE-050320-95 Length:712 Species:Danio rerio


Alignment Length:433 Identity:97/433 - (22%)
Similarity:173/433 - (39%) Gaps:117/433 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   342 LPGMRNLESLNLNRNLIKSIQNKALANFSRLVSLSLRHNQIDVLQDHAFFGLGALDSLDLSYNGI 406
            ||.  |..:|:|:.|.||.:::|...|.:::.||.|.||:|..::......|..|.:||:|.|.|
Zfish    51 LPS--NASTLSLSANKIKVLKSKTFVNVTQVTSLWLAHNEIITVERDTLAPLIQLKNLDISNNKI 113

  Fly   407 VAISSASLQHLSRLTVLDLTHNFLRALTSDLIAPLPSLRELRLAGNDISIVARNAMDGARELESL 471
            |......|.:|..|.:|.:.:|.:.::..:..:.|..||.:|:..|..:.:.:...|....:..|
Zfish   114 VHFPWEDLANLGALQLLKMNNNEMVSIPKNAFSNLKDLRSIRINNNKFTTIVQGTFDSLAAMSHL 178

  Fly   472 QMQENPLSCDCSIRPFAEWLQESQLHSSLS------ASCVTPPRLEGAPLLQVPVETLSCD---- 526
            |:..||..|.|::    |||::..|.||:|      .:|..|..|:|:.:..:|  .|:|.    
Zfish   179 QIFHNPFICSCNL----EWLRDWILKSSISIPEQNNIACDAPSHLKGSQVTSMP--KLNCKAPSV 237

  Fly   527 ----MDNVEK----DNANIMQHLETLAKP-----------NQ--TSPIKDLSEEIILHELHFSTD 570
                ..|:||    :...:|.:.||...|           ||  |.|:..:.|:           
Zfish   238 SITYQPNIEKTELYEGYMVMLYCETKGTPKPEVTWEIFAGNQLITFPLPAIVEK----------- 291

  Fly   571 YGLILTWLLNLSKKDYMCDAIFVYKEEHINEILIDNSPIHCESKVV-NGQNTVSVIVPDSSSLEI 634
                                         ::|.|:..|.:....|. ||    ::|||..|..|.
Zfish   292 -----------------------------SDIPINGPPTNTRFLVFQNG----TLIVPRMSKKEE 323

  Fly   635 GESYRFCLVMIQEQKPDSELNIGCSNITR------LERSSPGAVPVSRQYQRRPYYNANELKPEV 693
            | :|. |..:....|.:|.:.:..:...:      |:..|||.:|                    
Zfish   324 G-NYT-CSAVNDIGKAESSVRLVVAGTKKHATNSMLDTKSPGLLP-------------------- 366

  Fly   694 VHDAGEDYQVNQRRFNSVVGSQPQQTQQSTLLHSYTVIDSLNK 736
                 ||...::...|||:..:|:..:::..|.:.|.:.:::|
Zfish   367 -----EDKLGSKGSKNSVISMRPKFEEKTKSLPTGTSVITVDK 404

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LrtNP_001286640.1 LRR_RI <151..334 CDD:238064
leucine-rich repeat 179..199 CDD:275378
leucine-rich repeat 200..223 CDD:275380
leucine-rich repeat 225..248 CDD:275380
LRR_8 249..307 CDD:290566
leucine-rich repeat 249..272 CDD:275380
LRR_RI <270..479 CDD:238064 39/136 (29%)
leucine-rich repeat 273..296 CDD:275380
leucine-rich repeat 297..322 CDD:275380
LRR_8 322..382 CDD:290566 15/39 (38%)
leucine-rich repeat 323..347 CDD:275380 2/4 (50%)
leucine-rich repeat 348..371 CDD:275380 7/22 (32%)
LRR_8 370..428 CDD:290566 18/57 (32%)
leucine-rich repeat 372..395 CDD:275380 7/22 (32%)
leucine-rich repeat 396..419 CDD:275380 9/22 (41%)
LRR_8 418..478 CDD:290566 12/59 (20%)
leucine-rich repeat 420..443 CDD:275380 4/22 (18%)
leucine-rich repeat 444..467 CDD:275380 5/22 (23%)
LRRCT 476..526 CDD:214507 17/55 (31%)
islr2NP_001013541.1 leucine-rich repeat 35..53 CDD:275380 1/1 (100%)
LRR_RI <47..>184 CDD:238064 37/134 (28%)
LRR_8 53..113 CDD:290566 20/61 (33%)
leucine-rich repeat 57..78 CDD:275380 7/20 (35%)
leucine-rich repeat 79..102 CDD:275380 7/22 (32%)
LRR_8 102..161 CDD:290566 17/58 (29%)
leucine-rich repeat 103..126 CDD:275380 9/22 (41%)
leucine-rich repeat 127..150 CDD:275380 4/22 (18%)
leucine-rich repeat 151..174 CDD:275380 5/22 (23%)
LRRCT 183..>221 CDD:214507 14/41 (34%)
IG_like 252..345 CDD:214653 25/138 (18%)
Ig 256..345 CDD:299845 25/134 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24366
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
33.010

Return to query results.
Submit another query.