DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lrt and Toll-6

DIOPT Version :9

Sequence 1:	NP_001286640.1	Gene:	Lrt / 37342	FlyBaseID:	FBgn0034540	Length:	830	Species:	Drosophila melanogaster
Sequence 2:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster

Alignment Length:	799	Identity:	160/799 - (20%)
Similarity:	277/799 - (34%)	Gaps:	269/799 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 ILMLLLLCTLAAANDLKDLLEDSTT----------SSSTSTTSSTIPSSVTSPTTPTAYVVSAAA 84
            |..:||:..:..|.|.:...|..:|          |::....:....|.:..|:||      |..
  Fly     2 IYYMLLILPVVLAQDQQHTTESLSTKHHQQQQLSHSNAIMGEAGVSNSQLMQPSTP------ART 60

  Fly    85 VPALVAGRGKSKSTSGKYVNKSSPRKRKAEQVSSLPLPVDDALMEWKCPNITGTRNAELECGCDL 149
            :..|.||.|...|.                    ...|.|...|.     ..|....|:...|:|
  Fly    61 LRPLTAGAGGDPSL--------------------YDAPDDCHFMP-----AAGLDQPEIALTCNL 100

  Fly   150 -----------------PHTLRCNIDLHGMMLLADRLRTSPYS-------ISLLDCSLRNVTFLS 190
                             .||:..:|..:..::...||....::       :|:..|.|..:
  Fly   101 RTVNSEFDTTNFSVIPAEHTIALHILCNDEIMAKSRLEAQSFAHLVRLQQLSIQYCKLGRL---- 161

  Fly   191 DAKIFDNV-SLHGLVISSGEIK------RVHKSAFLGIRGPLQALGLPGNALMSVPWNALSTLSA 248
            ..::.|.: .|..|.:.:..|.      .:...|| .:...|:.|.|..|.:.|:|.|...|||.
  Fly   162 GRQVLDGLEQLRNLTLRTHNILWPALNFEIEADAF-SVTRRLERLDLSSNNIWSLPDNIFCTLSE 225

  Fly   249 LERLDLANNKIKAL--------------GTADFVGLT---------------SLVYLELSNNQIS 284
            |..|:::.|:::.:              |:.:....|               .|.||::|:|...
  Fly   226 LSALNMSENRLQDVNELGFRDRSKEPTNGSTESTSTTESAKKSSSSSTSCSLDLEYLDVSHNDFV 290

  Fly   285 SISQRTFVNLRKLEVLKLGGNRLGDYAQSLRSLSQCLSLRQLDLQANNLNGPLSEQTLPGMRNLE 349
            .:....|..||:|.||.:..|.:                           ..::::.|.|::||:
  Fly   291 VLPANGFGTLRRLRVLSVNNNGI---------------------------SMIADKALSGLKNLQ 328

  Fly   350 SLNLNRNLIKSIQNKALANFSRLV-SLSLRHNQIDVLQDHAFFGLGALDSLDLSYN--------- 404
            .|||:.|.|.::..:..|..:::: .:.|::|.|.||....|..|..|.:||||.|
  Fly   329 ILNLSSNKIVALPTELFAEQAKIIQEVYLQNNSISVLNPQLFSNLDQLQALDLSMNQITSTWIDK 393

  Fly   405 ----GIVAISSASLQH-------------LSRLTVLDLTHNFLRALTSDLIAPLPSLRELRLAGN 452
                |::.:...:|.|             |..|.:|:|.||.|..:.:|..||:.:|..|.|:.|
  Fly   394 NTFVGLIRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHTLLLSHN 458

  Fly   453 DISIVARNAMDGARELESLQMQENPLSCDCSIRPFAEWLQESQLHSSLSASCVTPPRLEGAPLLQ 517
            .:..:...|::|...|..|.:..|.|   ..:.|.|          ..:.|.:....|.|..|..
  Fly   459 KLKYLDAYALNGLYVLSLLSLDNNAL---IGVHPDA----------FRNCSALQDLNLNGNQLKT 510

  Fly   518 VPVETLSCDMDNVEKDNANIMQHLETLAKPNQTSPIKDLSEEII-------------LHELHFST 569
            ||:...:             |:||.|:          ||.|.:|             |:.|....
  Fly   511 VPLALRN-------------MRHLRTV----------DLGENMITVMEDSAFKGLGNLYGLRLIG 552

  Fly   570 DYGLILTW----------LLNLSKKDYMCDAIFVYK------EEHINEILIDNSPIHCESKVVNG 618
            :|...:|.          :|||::     :.|.|.:      ...|..:.:|.:    |...:||
  Fly   553 NYLENITMHTFRDLPNLQILNLAR-----NRIAVVEPGAFEMTSSIQAVRLDGN----ELNDING 608

  Fly   619 --QNTVSVI---VPDS--SSLEIGE------------------SYRFCLVMIQEQKPDSELNIGC 658
              .|..|::   :.|:  .|.:.|.                  |.||.|        ||||.:..
  Fly   609 LFSNMPSLLWLNISDNRLESFDYGHVPSTLQWLDLHKNRLSSLSNRFGL--------DSELKLQT 665

  Fly   659 SNIT--RLERSSPGAVPVS 675
            .:::  :|:|..|.::|.|
  Fly   666 LDVSFNQLQRIGPSSIPNS 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrt	NP_001286640.1	LRR_RI	<151..334	CDD:238064	41/225 (18%)
		leucine-rich repeat	179..199	CDD:275378	3/20 (15%)
		leucine-rich repeat	200..223	CDD:275380	5/28 (18%)
		leucine-rich repeat	225..248	CDD:275380	9/22 (41%)
		LRR_8	249..307	CDD:290566	17/86 (20%)
		leucine-rich repeat	249..272	CDD:275380	5/51 (10%)
		LRR_RI	<270..479	CDD:238064	58/250 (23%)
		leucine-rich repeat	273..296	CDD:275380	7/22 (32%)
		leucine-rich repeat	297..322	CDD:275380	4/24 (17%)
		LRR_8	322..382	CDD:290566	12/60 (20%)
		leucine-rich repeat	323..347	CDD:275380	2/23 (9%)
		leucine-rich repeat	348..371	CDD:275380	7/22 (32%)
		LRR_8	370..428	CDD:290566	20/84 (24%)
		leucine-rich repeat	372..395	CDD:275380	7/23 (30%)
		leucine-rich repeat	396..419	CDD:275380	10/48 (21%)
		LRR_8	418..478	CDD:290566	18/59 (31%)
		leucine-rich repeat	420..443	CDD:275380	9/22 (41%)
		leucine-rich repeat	444..467	CDD:275380	6/22 (27%)
		LRRCT	476..526	CDD:214507	10/49 (20%)
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380	4/26 (15%)
		LRR_8	171..236	CDD:290566	18/65 (28%)
		leucine-rich repeat	172..201	CDD:275380	5/29 (17%)
		leucine-rich repeat	202..278	CDD:275380	15/75 (20%)
		leucine-rich repeat	229..249	CDD:275380	2/19 (11%)
		LRR_RI	278..468	CDD:238064	52/216 (24%)
		leucine-rich repeat	279..302	CDD:275380	7/22 (32%)
		LRR_8	301..386	CDD:290566	28/111 (25%)
		leucine-rich repeat	303..326	CDD:275380	6/49 (12%)
		leucine-rich repeat	327..350	CDD:275380	7/22 (32%)
		LRR	350..729	CDD:227223	84/388 (22%)
		leucine-rich repeat	352..375	CDD:275380	7/22 (32%)
		leucine-rich repeat	376..401	CDD:275380	7/24 (29%)
		LRR_RI	<401..626	CDD:238064	55/269 (20%)
		leucine-rich repeat	402..425	CDD:275380	3/22 (14%)
		leucine-rich repeat	426..449	CDD:275380	9/22 (41%)
		leucine-rich repeat	450..473	CDD:275380	6/22 (27%)
		leucine-rich repeat	474..497	CDD:275380	6/35 (17%)
		leucine-rich repeat	498..518	CDD:275380	5/32 (16%)
		leucine-rich repeat	521..544	CDD:275380	6/32 (19%)
		leucine-rich repeat	545..566	CDD:275380	4/20 (20%)
		leucine-rich repeat	569..592	CDD:275380	5/27 (19%)
		leucine-rich repeat	593..615	CDD:275380	6/25 (24%)
		leucine-rich repeat	616..637	CDD:275380	3/20 (15%)
		leucine-rich repeat	638..662	CDD:275380	7/31 (23%)
		leucine-rich repeat	663..684	CDD:275380	4/20 (20%)
		leucine-rich repeat	685..708	CDD:275380	160/799 (20%)
		leucine-rich repeat	709..728	CDD:275380
		LRR_8	883..943	CDD:290566
		leucine-rich repeat	885..908	CDD:275380
		leucine-rich repeat	909..932	CDD:275380
		LRR_8	932..990	CDD:290566
		leucine-rich repeat	933..956	CDD:275380
		TIR	1114..1247	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910