DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lrt and 18w

DIOPT Version :9

Sequence 1:	NP_001286640.1	Gene:	Lrt / 37342	FlyBaseID:	FBgn0034540	Length:	830	Species:	Drosophila melanogaster
Sequence 2:	NP_476814.1	Gene:	18w / 37277	FlyBaseID:	FBgn0004364	Length:	1385	Species:	Drosophila melanogaster

Alignment Length:	587	Identity:	143/587 - (24%)
Similarity:	235/587 - (40%)	Gaps:	99/587 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 VNKSSPRKRKAEQVS-SLPLPVDDALMEWKCPNITGTRNAELECGCDLP------HTLRCNIDLH 160
            :|.:..|.|.||.:. |..|....||         ...|..:..|.:|.      :.||...|..
  Fly   174 LNLTQNRIRSAEFLGFSEKLCAGSAL---------SNANGAVSGGSELQTLDVSFNELRSLPDAW 229

  Fly   161 GMMLLADRLRTSPYSISLLDCSLRNVTFLSDAKIFDNVSLHGLVISSGEIKRVHKSAFLGIRGPL 225
            |    |.|||    .:..|.....|::.|:...:....||..|.||...:..:...||.|.: .|
  Fly   230 G----ASRLR----RLQTLSLQHNNISTLAPNALAGLSSLRVLNISYNHLVSLPSEAFAGNK-EL 285

  Fly   226 QALGLPGNALMSVPWNALSTLSALERLDLANNKIKA--LGTADFVGLTSLVYLELSNNQISSISQ 288
            :.|.|.||.|..:|...|..|..|..|||:.|::.:  :..:.|.||..|:.|.||||.::.|..
  Fly   286 RELHLQGNDLYELPKGLLHRLEQLLVLDLSGNQLTSHHVDNSTFAGLIRLIVLNLSNNALTRIGS 350

  Fly   289 RTFVNLRKLEVLKLGGNRLGDYAQSLRSLSQCLSLRQLDLQANNLNGPLSEQTLPGMRNLESLNL 353
            :||..|..|::|.:..|.:|...:.  :.....:|..|:|..|.|: .|..:...|:..|..|.|
  Fly   351 KTFKELYFLQILDMRNNSIGHIEEG--AFLPLYNLHTLNLAENRLH-TLDNRIFNGLYVLTKLTL 412

  Fly   354 NRNLIKSIQNKALANFSRLVSLSLRHNQI----DVLQDHAFFGLGALDSLDLSYNGIVAISSASL 414
            |.||:..::::|..|.|.|..|.|..||:    :.:||     |..|.:|||..|.|....:.:.
  Fly   413 NNNLVSIVESQAFRNCSDLKELDLSSNQLTEVPEAVQD-----LSMLKTLDLGENQISEFKNNTF 472

  Fly   415 QHLSRLTVLDLTHNFLRALTSDLIAPLPSLRELRLAGNDISIVARNAMDGARELESLQMQENPLS 479
            ::|::||.|.|..|.:..:|..:...||.|..|.||.|.|..:.|.|.|...|:|::::.:|.|:
  Fly   473 RNLNQLTGLRLIDNRIGNITVGMFQDLPRLSVLNLAKNRIQSIERGAFDKNTEIEAIRLDKNFLT 537

  Fly   480 CDCSIRPFAE-----WLQESQLHSSLSASCVTPPRLEGAPL-------------LQVPVETLSCD 526
            ....|  ||.     ||..|:.|.........|..|:...:             ||..:...:.|
  Fly   538 DINGI--FATLASLLWLNLSENHLVWFDYAFIPSNLKWLDIHGNYIEALGNYYKLQEEIRVTTLD 600

  Fly   527 MDNVEKDNANIMQHLETLAKPNQTSPIKDLSEEIILHELHFSTDYGLILTWLLNLSKKDYMCDAI 591
            ..:      |.:..:..::.||....:  .....|:.::..:|     ......|::.|...:.:
  Fly   601 ASH------NRITEIGAMSVPNSIELL--FINNNIIGQIQANT-----FVDKTRLARVDLYANVL 652

  Fly   592 F-----------VYKEEHINEILIDNSPIHCESKV-----VNGQNT-----------VSVIVPDS 629
            .           |..|:.:.|..:..:|..|:..:     :|...|           :..::|.|
  Fly   653 SKISLNALRVAPVSAEKPVPEFYLGGNPFECDCSMEWLQRINNLTTRQHPHVVDLGNIECLMPHS 717

  Fly   630 SS 631
            .|
  Fly   718 RS 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrt	NP_001286640.1	LRR_RI	<151..334	CDD:238064	54/184 (29%)
		leucine-rich repeat	179..199	CDD:275378	3/19 (16%)
		leucine-rich repeat	200..223	CDD:275380	7/22 (32%)
		leucine-rich repeat	225..248	CDD:275380	9/22 (41%)
		LRR_8	249..307	CDD:290566	21/59 (36%)
		leucine-rich repeat	249..272	CDD:275380	8/24 (33%)
		LRR_RI	<270..479	CDD:238064	66/212 (31%)
		leucine-rich repeat	273..296	CDD:275380	10/22 (45%)
		leucine-rich repeat	297..322	CDD:275380	4/24 (17%)
		LRR_8	322..382	CDD:290566	20/59 (34%)
		leucine-rich repeat	323..347	CDD:275380	7/23 (30%)
		leucine-rich repeat	348..371	CDD:275380	8/22 (36%)
		LRR_8	370..428	CDD:290566	20/61 (33%)
		leucine-rich repeat	372..395	CDD:275380	8/26 (31%)
		leucine-rich repeat	396..419	CDD:275380	7/22 (32%)
		LRR_8	418..478	CDD:290566	20/59 (34%)
		leucine-rich repeat	420..443	CDD:275380	7/22 (32%)
		leucine-rich repeat	444..467	CDD:275380	9/22 (41%)
		LRRCT	476..526	CDD:214507	13/67 (19%)
18w	NP_476814.1	leucine-rich repeat	66..91	CDD:275380
		leucine-rich repeat	92..115	CDD:275380
		LRR_8	115..181	CDD:290566	1/6 (17%)
		leucine-rich repeat	116..146	CDD:275380
		leucine-rich repeat	147..170	CDD:275380
		leucine-rich repeat	171..201	CDD:275380	9/35 (26%)
		LRR_RI	210..464	CDD:238064	80/270 (30%)
		leucine-rich repeat	212..236	CDD:275380	9/31 (29%)
		LRR_8	235..295	CDD:290566	17/64 (27%)
		leucine-rich repeat	237..260	CDD:275380	3/22 (14%)
		leucine-rich repeat	261..284	CDD:275380	7/23 (30%)
		LRR_8	283..345	CDD:290566	23/62 (37%)
		leucine-rich repeat	285..308	CDD:275380	9/22 (41%)
		leucine-rich repeat	309..334	CDD:275380	8/24 (33%)
		LRR_8	334..393	CDD:290566	18/60 (30%)
		leucine-rich repeat	335..358	CDD:275380	10/22 (45%)
		leucine-rich repeat	359..382	CDD:275380	4/24 (17%)
		LRR_8	382..441	CDD:290566	20/59 (34%)
		leucine-rich repeat	383..406	CDD:275380	7/23 (30%)
		leucine-rich repeat	407..430	CDD:275380	8/22 (36%)
		LRR_8	431..488	CDD:290566	20/61 (33%)
		leucine-rich repeat	431..451	CDD:275380	7/24 (29%)
		leucine-rich repeat	454..477	CDD:275380	7/22 (32%)
		LRR_8	477..559	CDD:290566	27/83 (33%)
		leucine-rich repeat	478..499	CDD:275380	6/20 (30%)
		leucine-rich repeat	502..525	CDD:275380	9/22 (41%)
		leucine-rich repeat	526..548	CDD:275380	6/23 (26%)
		leucine-rich repeat	590..617	CDD:275380	5/32 (16%)
		leucine-rich repeat	618..641	CDD:275380	2/29 (7%)
		leucine-rich repeat	642..689	CDD:275380	7/46 (15%)
		LRRCT	679..736	CDD:214507	7/41 (17%)
		leucine-rich repeat	775..796	CDD:275380
		LRR_8	797..852	CDD:290566
		leucine-rich repeat	797..817	CDD:275380
		leucine-rich repeat	818..841	CDD:275380
		LRR_8	841..900	CDD:290566
		leucine-rich repeat	842..865	CDD:275380
		LRR_4	866..907	CDD:289563
		leucine-rich repeat	866..889	CDD:275380
		leucine-rich repeat	890..911	CDD:275380
		TIR	1045..1183	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910