DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lrt and CG4168

DIOPT Version :9

Sequence 1:	NP_001286640.1	Gene:	Lrt / 37342	FlyBaseID:	FBgn0034540	Length:	830	Species:	Drosophila melanogaster
Sequence 2:	NP_001285953.1	Gene:	CG4168 / 34889	FlyBaseID:	FBgn0028888	Length:	1330	Species:	Drosophila melanogaster

Alignment Length:	645	Identity:	154/645 - (23%)
Similarity:	250/645 - (38%)	Gaps:	172/645 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 DLPHTLRCNIDLHGMMLLADRLRTSPYSISLLDCSLRNVTFLSDAKIFDNVS----LHGLVISSG 208
            ||.|...|::.|...:.:::  .|:|..:        ||:....|..:|.:|    ::.|.||..
  Fly   716 DLMHNQLCSLSLKSFLYVSN--TTTPLRL--------NVSHNHIASFYDELSSYMYIYQLDISHN 770

  Fly   209 EIKRVHKSAFLGIRGPLQALGLPGNALMSVPWNALSTLSALERLDLANNKIKALGTADFVGLTSL 273
            .:.:  ..:|..:...|:.|.|..|.|.|:..:|...|..||.|::|:|.:.:|....|.||.||
  Fly   771 HVTK--SDSFTNLANTLRFLNLAHNQLGSLQSHAFGDLEFLEILNVAHNNLTSLRRRSFQGLNSL 833

  Fly   274 VYLELSNNQISSISQRTFVNLRKLEVLKLGGNRLGDYAQSL-RSLSQCLSLRQLDLQANNLN-GP 336
            ..|:||:||:..:....|.|||||.:|::..|||    ::| |.:.....|..||:..|.|: .|
  Fly   834 QELDLSHNQLDQLQVEQFSNLRKLRILRINSNRL----RALPREVFMNTRLEFLDIAENQLSVWP 894

  Fly   337 LSEQTLPGMRNLESLNLNRNLIKSIQNKALANFSRLVSLSLRHNQIDVLQDHAFFGLGALDSLDL 401
            :...|..|. .|.|:.::.|.::.:......|...|..:||..|:|.:|.|:.|..|..|.:|||
  Fly   895 VPAFTDIGF-TLRSIQMSHNNLEYLDASMFINSQFLYDISLARNRITILPDNTFSFLNNLTNLDL 958

  Fly   402 SYNGIVAISSASL-QHLSRLTVLDLTHNFLRALTSDLIAPLPSLRELRLAGNDISIVARNAMDGA 465
            |.|.:|..:...: .|..||..|.|.|..|..|..   ..||.|..|.::||.:..:  :.:...
  Fly   959 SQNPLVTTNLREVFVHTPRLRKLSLHHMGLYVLPP---LKLPLLSYLDVSGNYLQEL--SPLGSL 1018

  Fly   466 RELESLQMQENPLSCDCSIRPFAEWLQESQLHSSLSASCVT---PPRLEGAPLLQVPVETLSCDM 527
            |.|..:.:..|.|:                     :|||..   ||.:....|...|:..::.
  Fly  1019 RHLRHVNVSHNKLT---------------------NASCAAEHLPPSVRVLDLAHNPLRRITL-- 1060

  Fly   528 DNVEKDNANIMQHLETL-------AKPNQTSPIKDLSEEIILHELHFST--DYGLILTWLLNLSK 583
                .|.|: ::||..|       ..|...|.::.      |.:||.|:  :.|.|:..:..|.:
  Fly  1061 ----HDLAS-LRHLAELNILDVKVTNPQAFSKLRS------LRKLHASSHANLGEIVARIPGLQQ 1114

  Fly   584 KDYMCDAIFVYKEEHINEILIDNSPIHCESKVVN----------GQNTVSVIVPD-------SSS 631
            ....|      .|.:|.:.|.        :|:.|          |.| |..|.||       |..
  Fly  1115 LRVHC------LEPNIGQQLF--------AKLANNTKIRLLELYGSN-VQTIAPDVFTGLSRSQR 1164

  Fly   632 LEIGESYRFCLVMIQEQKPDSELNIGCSNITRLERSSPGAVPVSRQYQRRPYYNANELKPEVVHD 696
            |::..|:                       ||:....||.           :|...|: |.:..|
  Fly  1165 LQVKISH-----------------------TRISDLPPGI-----------FYALREV-PHLSID 1194

  Fly   697 AGEDYQVNQRRFNSVVGSQPQQTQQSTLLHSYTVIDSL--NKSFLPGLG----LGVLVTS 750
                  ::..|.|::..                  ||.  |||:...:|    :|.|:||
  Fly  1195 ------ISHNRINALAA------------------DSFYPNKSYWDAVGTRSIMGGLITS 1230

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrt	NP_001286640.1	LRR_RI	<151..334	CDD:238064	54/187 (29%)
		leucine-rich repeat	179..199	CDD:275378	4/19 (21%)
		leucine-rich repeat	200..223	CDD:275380	4/22 (18%)
		leucine-rich repeat	225..248	CDD:275380	8/22 (36%)
		LRR_8	249..307	CDD:290566	24/57 (42%)
		leucine-rich repeat	249..272	CDD:275380	9/22 (41%)
		LRR_RI	<270..479	CDD:238064	65/211 (31%)
		leucine-rich repeat	273..296	CDD:275380	9/22 (41%)
		leucine-rich repeat	297..322	CDD:275380	7/25 (28%)
		LRR_8	322..382	CDD:290566	16/60 (27%)
		leucine-rich repeat	323..347	CDD:275380	8/24 (33%)
		leucine-rich repeat	348..371	CDD:275380	4/22 (18%)
		LRR_8	370..428	CDD:290566	21/58 (36%)
		leucine-rich repeat	372..395	CDD:275380	9/22 (41%)
		leucine-rich repeat	396..419	CDD:275380	8/23 (35%)
		LRR_8	418..478	CDD:290566	16/59 (27%)
		leucine-rich repeat	420..443	CDD:275380	7/22 (32%)
		leucine-rich repeat	444..467	CDD:275380	4/22 (18%)
		LRRCT	476..526	CDD:214507	9/52 (17%)
CG4168	NP_001285953.1	leucine-rich repeat	99..118	CDD:275380
		LRR_8	121..181	CDD:290566
		LRR_RI	122..350	CDD:238064
		leucine-rich repeat	122..146	CDD:275380
		leucine-rich repeat	147..170	CDD:275380
		leucine-rich repeat	171..194	CDD:275380
		leucine-rich repeat	195..214	CDD:275380
		leucine-rich repeat	215..236	CDD:275380
		LRR_8	265..322	CDD:290566
		leucine-rich repeat	266..287	CDD:275380
		leucine-rich repeat	288..311	CDD:275380
		leucine-rich repeat	312..338	CDD:275380
		LRR_RI	315..546	CDD:238064
		leucine-rich repeat	339..365	CDD:275380
		LRR_8	365..424	CDD:290566
		leucine-rich repeat	366..388	CDD:275380
		leucine-rich repeat	389..412	CDD:275380
		LRR_8	413..470	CDD:290566
		leucine-rich repeat	414..436	CDD:275380
		leucine-rich repeat	437..459	CDD:275380
		leucine-rich repeat	460..483	CDD:275380
		LRR_8	482..545	CDD:290566
		leucine-rich repeat	484..510	CDD:275380
		leucine-rich repeat	511..534	CDD:275380
		leucine-rich repeat	535..589	CDD:275380
		LRR_RI	588..891	CDD:238064	56/190 (29%)
		LRR_8	588..650	CDD:290566
		leucine-rich repeat	590..613	CDD:275380
		leucine-rich repeat	614..639	CDD:275380
		LRR_8	638..698	CDD:290566
		leucine-rich repeat	640..663	CDD:275380
		leucine-rich repeat	664..687	CDD:275380
		LRR_8	688..749	CDD:290566	9/42 (21%)
		leucine-rich repeat	688..711	CDD:275380
		leucine-rich repeat	712..735	CDD:275380	5/18 (28%)
		leucine-rich repeat	740..783	CDD:275380	9/52 (17%)
		LRR_8	784..843	CDD:290566	23/58 (40%)
		leucine-rich repeat	785..808	CDD:275380	8/22 (36%)
		leucine-rich repeat	809..832	CDD:275380	9/22 (41%)
		LRR_RI	<827..1053	CDD:238064	74/256 (29%)
		LRR_8	832..890	CDD:290566	23/61 (38%)
		leucine-rich repeat	833..856	CDD:275380	9/22 (41%)
		leucine-rich repeat	857..879	CDD:275380	7/25 (28%)
		leucine-rich repeat	880..900	CDD:275380	6/19 (32%)
		LRR_8	904..963	CDD:290566	19/58 (33%)
		leucine-rich repeat	905..928	CDD:275380	4/22 (18%)
		leucine-rich repeat	929..952	CDD:275380	9/22 (41%)
		leucine-rich repeat	953..977	CDD:275380	8/23 (35%)
		leucine-rich repeat	978..1020	CDD:275380	12/46 (26%)
		LRR_8	1019..1074	CDD:290566	16/82 (20%)
		leucine-rich repeat	1045..1068	CDD:275380	4/29 (14%)
		leucine-rich repeat	1069..1090	CDD:275380	4/20 (20%)
		leucine-rich repeat	1091..1114	CDD:275380	7/22 (32%)
		leucine-rich repeat	1115..1161	CDD:275380	12/60 (20%)
		leucine-rich repeat	1162..1190	CDD:275380	9/62 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910