DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lrt and AMIGO2

DIOPT Version :9

Sequence 1:NP_001286640.1 Gene:Lrt / 37342 FlyBaseID:FBgn0034540 Length:830 Species:Drosophila melanogaster
Sequence 2:NP_001137140.1 Gene:AMIGO2 / 347902 HGNCID:24073 Length:522 Species:Homo sapiens


Alignment Length:518 Identity:99/518 - (19%)
Similarity:153/518 - (29%) Gaps:243/518 - (46%)


- Green bases have known domain annotations that are detailed below.


  Fly   235 LMSVPWNALSTLSALERLDLANNKIKALGT----ADFVGLTSLVYLELSNNQISSISQRTFVNLR 295
            |..||.|   ....::||||:.|:|..|.:    ..|..|.:|:   |.:|.|:|||..:|    
Human    59 LSKVPGN---LFRLIKRLDLSYNRIGLLDSEWIPVSFAKLNTLI---LRHNNITSISTGSF---- 113

  Fly   296 KLEVLKLGGNRLGDYAQSLRSLSQCLSLRQLDLQANNLNGPLSEQTLPGMRNLESLNLNRNLIKS 360
                                                        .|.|   ||:.|:|:.|.:|:
Human   114 --------------------------------------------STTP---NLKCLDLSSNKLKT 131

  Fly   361 IQNKALANFSRLVSLSLRHNQIDVLQDHAFFGLGALDSLDLSYNGIVAISS---ASLQHLSRLTV 422
            ::|........|..|.|.:|.|..|...||.||..|..|.||.|.:.....   .....|:.|..
Human   132 VKNAVFQELKVLEVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMF 196

  Fly   423 LDLTHNFLRALTSDLIAPLPSLRELRLAGNDISIVARNAMDGARELESLQMQENPLSCDCSIRPF 487
            ||:::|.:.::....|..:|                      .::|..:.:..||..||||    
Human   197 LDVSYNRIPSMPMHHINLVP----------------------GKQLRGIYLHGNPFVCDCS---- 235

  Fly   488 AEWLQESQLHSSLSASCVTPPRLEGAPLLQVPVETLSCDMDNVEKDNANIMQHLETLAKPNQTSP 552
                    |:|.|                                                    
Human   236 --------LYSLL---------------------------------------------------- 240

  Fly   553 IKDLSEEIILHELHFST--DYGLILTWLLNLSKKDYMC-----------------------DAI- 591
                   :..:..|||:  |:           |.||.|                       |:| 
Human   241 -------VFWYRRHFSSVMDF-----------KNDYTCRLWSDSRHSRQVLLLQDSFMNCSDSII 287

  Fly   592 --------FVYKEEHINEILIDNSPIHCESKVVNGQNTVSVIVPDSSSLE--------------- 633
                    |:: |..:.|.|:    :||:||..|.......:.||:..||               
Human   288 NGSFRALGFIH-EAQVGERLM----VHCDSKTGNANTDFIWVGPDNRLLEPDKEMENFYVFHNGS 347

  Fly   634 -IGESYRF-------CLVMIQEQ--KPDSELNIGCSNITRLERSSPGAVPVSRQYQRRPYYNA 686
             :.||.||       |:.|.:::  ....::.|..||.|           |||.:....:..|
Human   348 LVIESPRFEDAGVYSCIAMNKQRLLNETVDVTINVSNFT-----------VSRSHAHEAFNTA 399

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LrtNP_001286640.1 LRR_RI <151..334 CDD:238064 21/102 (21%)
leucine-rich repeat 179..199 CDD:275378
leucine-rich repeat 200..223 CDD:275380
leucine-rich repeat 225..248 CDD:275380 4/12 (33%)
LRR_8 249..307 CDD:290566 17/61 (28%)
leucine-rich repeat 249..272 CDD:275380 9/26 (35%)
LRR_RI <270..479 CDD:238064 43/211 (20%)
leucine-rich repeat 273..296 CDD:275380 8/22 (36%)
leucine-rich repeat 297..322 CDD:275380 0/24 (0%)
LRR_8 322..382 CDD:290566 13/59 (22%)
leucine-rich repeat 323..347 CDD:275380 2/23 (9%)
leucine-rich repeat 348..371 CDD:275380 6/22 (27%)
LRR_8 370..428 CDD:290566 19/60 (32%)
leucine-rich repeat 372..395 CDD:275380 10/22 (45%)
leucine-rich repeat 396..419 CDD:275380 6/25 (24%)
LRR_8 418..478 CDD:290566 8/59 (14%)
leucine-rich repeat 420..443 CDD:275380 5/22 (23%)
leucine-rich repeat 444..467 CDD:275380 0/22 (0%)
LRRCT 476..526 CDD:214507 9/49 (18%)
AMIGO2NP_001137140.1 leucine-rich repeat 51..72 CDD:275380 4/15 (27%)
LRR <54..>240 CDD:227223 61/271 (23%)
LRR 1 69..90 7/20 (35%)
leucine-rich repeat 73..95 CDD:275380 7/21 (33%)
LRR_8 94..175 CDD:338972 32/134 (24%)
LRR 2 94..115 9/71 (13%)
leucine-rich repeat 97..118 CDD:275380 10/74 (14%)
LRR 3 118..139 7/20 (35%)
leucine-rich repeat 119..142 CDD:275380 6/22 (27%)
LRR 4 142..163 8/20 (40%)
leucine-rich repeat 143..166 CDD:275380 10/22 (45%)
LRR 5 166..187 5/20 (25%)
leucine-rich repeat 167..193 CDD:275380 6/25 (24%)
LRR 6 193..214 5/20 (25%)
leucine-rich repeat 194..219 CDD:275380 6/46 (13%)
TPKR_C2 228..283 CDD:387596 17/136 (13%)
IG_like 298..380 CDD:214653 18/86 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 501..522
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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