DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lrt and LRIT2

DIOPT Version :9

Sequence 1:	NP_001286640.1	Gene:	Lrt / 37342	FlyBaseID:	FBgn0034540	Length:	830	Species:	Drosophila melanogaster
Sequence 2:	NP_001271152.1	Gene:	LRIT2 / 340745	HGNCID:	23443	Length:	560	Species:	Homo sapiens

Alignment Length:	501	Identity:	106/501 - (21%)
Similarity:	172/501 - (34%)	Gaps:	179/501 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   270 LTSLVYLE-------------LSNNQISSISQRTFVNLRKLEVLKLGGNRLGDYAQSLRSLSQCL 321
            |..||:|:             .|........|.|.|:|.|:.     ||           ||:
Human     9 LLVLVFLDTHAAQPFCLPGCTCSEESFGRTLQCTSVSLGKIP-----GN-----------LSE-- 55

  Fly   322 SLRQLDLQANNLNGPLSEQ---TLPGMRNLESLNLNRNLIKSIQNKALANFSRLVSLSLRHNQID 383
            ..:|:.::    |.||.|.   :...|..||.|.||.|.|..|...||.:...|..|.|..|::.
Human    56 EFKQVRIE----NSPLFEMPQGSFINMSTLEYLWLNFNNISVIHLGALEHLPELRELRLEGNKLC 116

  Fly   384 VLQDHAFFGLGALDSLDLSYNGIVAISSASLQHLSRLTVLDLTHNFLRALTSDLIAPLPSLRELR 448
            .:...||.....|..|||..|.|.|:...:||.|..||.|||:.|.|..::..:....|:.::
Human   117 SVPWTAFRATPLLRVLDLKRNKIDALPELALQFLVSLTYLDLSSNRLTVVSKSVFLNWPAYQK-- 179

  Fly   449 LAGNDISIVARNAMDGARELESL--QMQENPLSCDCSIRPFAEWLQESQL--------------- 496
                     .|....||..|.||  .:.:||..|||.:|...::::...|
Human   180 ---------CRQPDCGAEILSSLVVALHDNPWVCDCRLRGLVQFVKSITLPVILVNSYLICQGPL 235

  Fly   497 -------HSSLSASCVTP----------------------------PRLEGA-PL---------- 515
                   |.:..::|:.|                            |.:... ||
Human   236 SKAGQLFHETELSACMKPQISTPSANITIRAGQNVTLRCLAQASPSPSIAWTYPLSMWREFDGLL 300

  Fly   516 ---------------------LQVPVETL------SCDMDN-VEKDNANIMQHL---------ET 543
                                 |.:|...|      :|...| :.|.|..|..|:         ::
Human   301 GGKHLTPVLTSSTGEDTALSELAIPAAHLVDSGNYTCMASNSIGKSNLVISLHVQPAQALHAPDS 365

  Fly   544 LAKPNQTSPIKDLSEEIILHELHFSTDYGLILTWL--LNLSKKDYMCDAIFVYKEEHINEILIDN 606
            |:.|::.:...||  .::...:|     |::|.||  .:.||:::.  .:::..:|...:.::..
Human   366 LSIPSEGNAYIDL--RVVKQTVH-----GILLEWLAVADTSKEEWF--TLYIASDEAFRKEVVHI 421

  Fly   607 SPIHCESKVVNGQNTVSV--IVPDSSSLEIGESYRFCLVMIQEQKP 650
            .|         |.||.:|  ::|       |..|..|| .::.|.|
Human   422 GP---------GINTYAVDDLLP-------GTKYEACL-SLEGQPP 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrt	NP_001286640.1	LRR_RI	<151..334	CDD:238064	15/76 (20%)
		leucine-rich repeat	179..199	CDD:275378
		leucine-rich repeat	200..223	CDD:275380
		leucine-rich repeat	225..248	CDD:275380
		LRR_8	249..307	CDD:290566	12/49 (24%)
		leucine-rich repeat	249..272	CDD:275380	1/1 (100%)
		LRR_RI	<270..479	CDD:238064	62/226 (27%)
		leucine-rich repeat	273..296	CDD:275380	8/35 (23%)
		leucine-rich repeat	297..322	CDD:275380	4/24 (17%)
		LRR_8	322..382	CDD:290566	20/62 (32%)
		leucine-rich repeat	323..347	CDD:275380	6/26 (23%)
		leucine-rich repeat	348..371	CDD:275380	10/22 (45%)
		LRR_8	370..428	CDD:290566	21/57 (37%)
		leucine-rich repeat	372..395	CDD:275380	6/22 (27%)
		leucine-rich repeat	396..419	CDD:275380	10/22 (45%)
		LRR_8	418..478	CDD:290566	15/61 (25%)
		leucine-rich repeat	420..443	CDD:275380	7/22 (32%)
		leucine-rich repeat	444..467	CDD:275380	3/22 (14%)
		LRRCT	476..526	CDD:214507	16/137 (12%)
LRIT2	NP_001271152.1	leucine-rich repeat	37..55	CDD:275380	8/33 (24%)
		leucine-rich repeat	58..80	CDD:275378	6/25 (24%)
		LRR_8	60..115	CDD:290566	19/58 (33%)
		LRR_RI	<75..164	CDD:238064	33/88 (38%)
		LRR 1	80..103		10/22 (45%)
		LRR_4	81..119	CDD:289563	14/37 (38%)
		leucine-rich repeat	81..104	CDD:275378	10/22 (45%)
		LRR_8	103..163	CDD:290566	22/59 (37%)
		LRR 2	104..125		6/20 (30%)
		leucine-rich repeat	105..128	CDD:275378	6/22 (27%)
		LRR 3	128..149		8/20 (40%)
		leucine-rich repeat	129..152	CDD:275378	10/22 (45%)
		LRR 4	152..173		7/20 (35%)
		leucine-rich repeat	153..164	CDD:275378	6/10 (60%)
		leucine-rich repeat	193..204	CDD:275378	3/10 (30%)
		TPKR_C2	200..243	CDD:301599	7/42 (17%)
		I-set	253..354	CDD:254352	12/100 (12%)
		IGc2	267..344	CDD:197706	8/76 (11%)
		FN3	377..440	CDD:214495	17/87 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	518..560
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910