DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lrt and LRRC66

DIOPT Version :9

Sequence 1:NP_001286640.1 Gene:Lrt / 37342 FlyBaseID:FBgn0034540 Length:830 Species:Drosophila melanogaster
Sequence 2:NP_001019782.1 Gene:LRRC66 / 339977 HGNCID:34299 Length:880 Species:Homo sapiens


Alignment Length:624 Identity:129/624 - (20%)
Similarity:218/624 - (34%) Gaps:186/624 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   249 LERLDLANNKIKALGTADFVGLTSLVYLELSNNQISSISQRTFVNLRKLEVLKLGGNRLGDYAQS 313
            ::.|||:||.|..:..:.|..|.:|..|.||||.|.|:|         |::|....:.:..:..|
Human    87 IKHLDLSNNLISKITLSPFAYLHALEVLNLSNNAIHSLS---------LDLLSPKSSWVKRHRSS 142

  Fly   314 LRSLSQCLSLRQLDLQANNLNGPLSEQTLPGMRNLESLNLNRNLIKSIQNKALANFSRLVSLSLR 378
            .|:....|.:  |.||.|.|:.  :.:.|..:::|:||:|:.|.|..|......|..:|.:|.|:
Human   143 FRNRFPLLKV--LILQRNKLSD--TPKGLWKLKSLQSLDLSFNGILQIGWSDFHNCLQLENLCLK 203

  Fly   379 HNQIDVLQDHAFFGLGALDSLDLSYNGIVAISSASLQHLSRLTVLDLTHNFLRALTSDLIAPLPS 443
            .|:|..:...||..|..|..:|||.|.::.|..      ..:..|:..|     |..||      
Human   204 SNKIFKIPPQAFKDLKKLQVIDLSNNALITILP------MMIIALEFPH-----LVVDL------ 251

  Fly   444 LRELRLAGNDISIVARNAMDGARELESLQMQENPLSCDCSIRPFAEWLQES---QLHSSLSASCV 505
                                          .:|...||.|:..|..::.||   :.:...:.|..
Human   252 ------------------------------ADNNWQCDDSVAVFQNFISESWRKKWNVICNRSIG 286

  Fly   506 TPPRLEGAPLLQVPVET----------LSCDMDNVEKDNANIMQHLETLAK-------------- 546
            :.....|.|..::..||          .|......|:........:.||.|              
Human   287 SEEANGGTPQSRISRETRLPPIHLHRMKSLIRSKAERPQGGRHTGISTLGKKAKAGSGLRKKQRR 351

  Fly   547 -PNQTSPIKDL----SEEIILHELHFSTDYGLILTWLLNLS----KKDYMCDAIFVYK------- 595
             |......:|:    .:|....:|..:....:.:|:|:..|    .:.|: |.::..|       
Human   352 LPRSVRSTRDVQAAGKKEDAPQDLALAVCLSVFITFLVAFSLGAFTRPYV-DRLWQKKCQSKSPG 415

  Fly   596 -----------------------EEHINEI-----LIDN-SPIHCESKVVNGQNTVSVIVPDSSS 631
                                   |.|:.::     |.:| :|..     |...:..:.::||.: 
Human   416 LDNAYSNEGFYDDMEAAGHTPHPETHLRQVFPHLSLYENQTPFW-----VTQPHPHATVIPDRT- 474

  Fly   632 LEIGESYRFCLVMIQEQKPDSELNIG-CSNITRLERSSPGAVPVSRQY---QRRPYYNANELKPE 692
              :|.|         .:.|.|..:.| |.:.|.....:.|||     |   ||.|:....||.  
Human   475 --LGRS---------RKDPGSSQSPGQCGDNTGAGSGNDGAV-----YSILQRHPHAGNRELM-- 521

  Fly   693 VVHDAGEDYQVNQRRFNSVVGSQPQQT--QQSTL-LHSYTVIDSLNKSFL-------------PG 741
               .|.:|: :::   |.::|....:|  |:..| .||..|......|..             |.
Human   522 ---SAAQDH-IHR---NDILGEWTYETVAQEEPLSAHSVGVSSVAGTSHAVSGSSRYDSNELDPS 579

  Fly   742 LGLGVLVTSVLVLIWGATRIRQTGGSSGGGGRNGDSIDS 780
            |. |.:..|:..::..| ..::||.|...||......||
Human   580 LS-GEITASLCKMLTHA-EAQRTGDSKERGGTEQSLWDS 616

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LrtNP_001286640.1 LRR_RI <151..334 CDD:238064 26/84 (31%)
leucine-rich repeat 179..199 CDD:275378
leucine-rich repeat 200..223 CDD:275380
leucine-rich repeat 225..248 CDD:275380
LRR_8 249..307 CDD:290566 19/57 (33%)
leucine-rich repeat 249..272 CDD:275380 8/22 (36%)
LRR_RI <270..479 CDD:238064 49/208 (24%)
leucine-rich repeat 273..296 CDD:275380 9/22 (41%)
leucine-rich repeat 297..322 CDD:275380 4/24 (17%)
LRR_8 322..382 CDD:290566 18/59 (31%)
leucine-rich repeat 323..347 CDD:275380 6/23 (26%)
leucine-rich repeat 348..371 CDD:275380 8/22 (36%)
LRR_8 370..428 CDD:290566 15/57 (26%)
leucine-rich repeat 372..395 CDD:275380 8/22 (36%)
leucine-rich repeat 396..419 CDD:275380 6/22 (27%)
LRR_8 418..478 CDD:290566 6/59 (10%)
leucine-rich repeat 420..443 CDD:275380 5/22 (23%)
leucine-rich repeat 444..467 CDD:275380 0/22 (0%)
LRRCT 476..526 CDD:214507 13/62 (21%)
LRRC66NP_001019782.1 LRR_RI 60..>255 CDD:238064 55/227 (24%)
leucine-rich repeat 64..86 CDD:275380
LRR_8 86..160 CDD:290566 26/83 (31%)
LRR 1 86..107 7/19 (37%)
leucine-rich repeat 88..110 CDD:275380 8/21 (38%)
LRR 2 110..130 10/28 (36%)
leucine-rich repeat 111..149 CDD:275380 13/46 (28%)
LRR 3 149..171 7/25 (28%)
leucine-rich repeat 150..172 CDD:275380 7/25 (28%)
LRR_8 171..231 CDD:290566 21/59 (36%)
LRR 4 172..193 7/20 (35%)
leucine-rich repeat 173..196 CDD:275380 8/22 (36%)
LRR 5 196..217 7/20 (35%)
leucine-rich repeat 197..220 CDD:275380 8/22 (36%)
LRR 6 220..241 6/26 (23%)
leucine-rich repeat 221..242 CDD:275380 6/26 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 319..368 6/48 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 463..504 9/52 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 679..746
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 764..816
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 855..880
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24366
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.100

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