DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lrt and Islr2

DIOPT Version :9

Sequence 1:	NP_001286640.1	Gene:	Lrt / 37342	FlyBaseID:	FBgn0034540	Length:	830	Species:	Drosophila melanogaster
Sequence 2:	NP_001155007.1	Gene:	Islr2 / 320563	MGIID:	2444277	Length:	789	Species:	Mus musculus

Alignment Length:	423	Identity:	107/423 - (25%)
Similarity:	167/423 - (39%)	Gaps:	103/423 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   342 LPGMRNLESLNLNRNLIKSIQNKALANFSRLVSLSLRHNQIDVLQDHAFFGLGALDSLDLSYNGI 406
            ||.  |:.:|:|:.|.|..::..|..|.:::.||.|.|:::..::..|...|..|.:||||:|.|
Mouse    93 LPA--NVTTLSLSANKITVLRRGAFVNVTQVTSLWLAHSEVRTVESGALAVLSQLKNLDLSHNLI 155

  Fly   407 VAISSASLQHLSRLTVLDLTHNFLRALTSDLIAPLPSLRELRLAGNDISIVARNAMDGARELESL 471
            .....:.|::||.|.:|.:.||.|.:|..|.:..||.||.||:..|.:..:.....|....|..|
Mouse   156 SNFPWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLEPGTFDALSALSHL 220

  Fly   472 QMQENPLSCDCSIRPFAEWLQ--ESQLHSSL----SASCVTPPRLEGAPLLQVPVETLSCDMDNV 530
            |:..||..|.|.:    .|||  .:....||    |.:|.:||.|:|.|:.::|  .|.|...:|
Mouse   221 QLYHNPFHCSCGL----VWLQAWAASTRVSLPEPDSIACASPPELQGVPVHRLP--ALPCAPPSV 279

  Fly   531 EKDNANIMQHLETLAKPNQTSPIKDLSEEI--ILH---ELHFSTDYGLILTWLLNLSKKDYMCDA 590
            ...           |:|...:|...|...:  :||   |.|.:..    |.|.|.:.....:...
Mouse   280 RLS-----------AEPPPEAPGTPLRAGLAFMLHCVAEGHPTPR----LQWQLQIPGGTVVLVP 329

  Fly   591 IFVYKEEHINEILIDNS-------PIHCES-------------------KVVNGQNTVSVIVPDS 629
            ..:.|||...:.:.|..       |...|:                   .:.||    |::||..
Mouse   330 PVLSKEEDGGDKVEDGEGDGDEDLPTQTEAPTPTPAPAWPAPPATPRFLALANG----SLLVPLL 390

  Fly   630 SSLEIGESYRFCLVMIQEQKPDSELNIGCSNITRLERSSPGAVPVSRQYQRRPYYNANELKPEVV 694
            |:.|.|         |...:..:||.   :|.|.|..:...|.|                 |:..
Mouse   391 SAKEAG---------IYTCRAHNELG---TNSTSLRVTVAAAGP-----------------PKHA 426

  Fly   695 HDAGE--DYQV--------NQRRFNSVVGSQPQ 717
            ...||  |.||        .:.|.|||:..:|:
Mouse   427 PGTGEEPDAQVPTSERKATTKGRSNSVLPFKPE 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrt	NP_001286640.1	LRR_RI	<151..334	CDD:238064
		leucine-rich repeat	179..199	CDD:275378
		leucine-rich repeat	200..223	CDD:275380
		leucine-rich repeat	225..248	CDD:275380
		LRR_8	249..307	CDD:290566
		leucine-rich repeat	249..272	CDD:275380
		LRR_RI	<270..479	CDD:238064	45/136 (33%)
		leucine-rich repeat	273..296	CDD:275380
		leucine-rich repeat	297..322	CDD:275380
		LRR_8	322..382	CDD:290566	13/39 (33%)
		leucine-rich repeat	323..347	CDD:275380	2/4 (50%)
		leucine-rich repeat	348..371	CDD:275380	6/22 (27%)
		LRR_8	370..428	CDD:290566	18/57 (32%)
		leucine-rich repeat	372..395	CDD:275380	6/22 (27%)
		leucine-rich repeat	396..419	CDD:275380	9/22 (41%)
		LRR_8	418..478	CDD:290566	20/59 (34%)
		leucine-rich repeat	420..443	CDD:275380	8/22 (36%)
		leucine-rich repeat	444..467	CDD:275380	6/22 (27%)
		LRRCT	476..526	CDD:214507	18/55 (33%)
Islr2	NP_001155007.1	leucine-rich repeat	80..96	CDD:275380	2/4 (50%)
		LRR_8	96..155	CDD:290566	19/58 (33%)
		leucine-rich repeat	97..120	CDD:275380	6/22 (27%)
		leucine-rich repeat	121..144	CDD:275380	6/22 (27%)
		LRR_4	144..183	CDD:289563	15/38 (39%)
		leucine-rich repeat	145..168	CDD:275380	9/22 (41%)
		LRR_8	164..227	CDD:290566	21/62 (34%)
		LRR_4	169..208	CDD:289563	14/38 (37%)
		leucine-rich repeat	169..192	CDD:275380	8/22 (36%)
		leucine-rich repeat	193..216	CDD:275380	6/22 (27%)
		LRRCT	225..273	CDD:214507	17/53 (32%)
		Ig_2	288..417	CDD:290606	29/148 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24366
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010