Protein Alignment Lrt and Lrrn4

DIOPT Version :10

• Sequence 1: NP_001286640.1
• Gene: Lrt / 37342
• FlyBaseID: FBgn0034540
• Length: 830
• Species: Drosophila melanogaster
• Sequence 2: NP_001417380.1
• Gene: Lrrn4 / 311443
• RGDID: 1305256
• Length: 735
• Species: Rattus norvegicus
• Alignment Length: 764
• Identity: 156/764 - (20%)
• Similarity: 261/764 - (34%)
• Gaps: 261/764 - (34%)

  Fly   144 ECGCD-LPHTLRCNIDLHGMMLLADRLRTS-PYSISLLDCSLRNVTFLSDAKIFDNVSLHGLVIS 206
            :..|: ||......::|....|  :||.:. |.::.:||.| .|:             ||.|  |
  Rat    52 DSSCEGLPAAGATTLNLANRSL--ERLPSCLPRTLRILDGS-HNL-------------LHAL--S 98

  Fly   207 SGEIKRVHKSAFLGIRGPLQALGLPGNALMSVPWNALSTLSALERLDLANNKIKALGTADFVGLT 271
            ...::|:.:         |..|.|..|.:..:.|:. ||.:.|..|||::|.:..|.....:..:
  Rat    99 EPVLRRLPE---------LSVLTLHHNRISVLHWDG-STPTGLHELDLSHNLLAELPPCSGLSRS 153

  Fly   272 SLVYLELSNNQISSISQRTFVNLRKLEVLKLGGNRLGDYAQSLRSLSQCLSLRQLDLQANNLNGP 336
            ||..|.|:.|.:.::..|||....:|:.|.|..::||..||.        :...:|      .||
  Rat   154 SLSLLSLAGNPLQALQPRTFACFPELQFLNLSCSKLGHIAQE--------AFAGVD------GGP 204

  Fly   337 LSEQTLPGMRNLESLNLNRNLIKSIQNKALANFSRLVSLSLRH-NQIDVLQDHAFFGLGALDSLD 400
            |..        ||.|:|:...::.::::.:.|..:|.||.||. .::..|:...|
  Rat   205 LEA--------LELLDLSGTNLERVESEWIRNLPKLKSLYLRKMPRLKTLEGDIF---------- 251

  Fly   401 LSYNGIVAISSASLQHLSRLTVLDLTHNFLRALTS---DLIAPLPSLRELRLAGNDISIVARNAM 462
                          :....|.:||...:  .||||   ::....|:|:.|:|...::|......:
  Rat   252 --------------KMTPNLRLLDCQES--PALTSVHTEIFQDTPNLQVLQLQNCNLSSFGPWTV 300

  Fly   463 DGARELESLQMQENPLSCDCSIRPFAEWL----QESQLHSSLSASCVTPPRLEGAPLLQVPVETL 523
            :.::.| .:.:..|||.|.|.:    .||    .::.||.:...:|......:|.....:|:..|
  Rat   301 NSSQVL-LVSLFGNPLICSCEL----AWLLLDASKTVLHRAADTTCEPALGSKGPFSGPLPLSHL 360

  Fly   524 S--CDMD--------NVEKDNANI-----------------------MQHLE-----TLAKPNQT 550
            |  |..|        |...|:.::                       .|::.     |:|.|.|.
  Rat   361 SNVCRSDQSTTLLASNPPHDHHSVSAPWTQEPSIGQSRALSAQPEGSQQNITKVPSLTMAPPTQG 425

  Fly   551 S-PIKDLSEEIIL----HELHFS---------------TDYGLILTWLLNLSKKDYMCDAIFVYK 595
            | ..:|.|||...    .|:.:|               ||     |::|..|........:..|.
  Rat   426 SRTYRDTSEETAQSTTNSEIVYSPSRALPGTASSGAEQTD-----TYILEPSISSASTPLVSKYL 485

  Fly   596 E-----------EHINE--------------------ILIDNSP--------------------- 608
            |           ..||:                    :|:|:..
  Rat   486 EPSPTSPNPRSISQINQRTQANPKAFHTDPPQDEIPVLLLDDDSEEETTQDQVAAPRQDVSCDYH 550

  Fly   609 ---------------IHCESKVVNGQNTVSVIVPDSSSLEIGESYRFCLVMIQEQKPDSEL---- 654
                           :.|....::||:|    :||...|:.........|:|....|:|.:
  Rat   551 PCRHLQTPCAELQKRLRCRCPGLSGQDT----IPDPPKLQGVSEMTDTSVLIHWCAPNSVVLWYQ 611

  Fly   655 -----NIGCSNITRLERSSPGAVPVSRQYQRRPYYNANELKPEVVHDAGEDYQVNQRRFNSVVGS 714
                 ..|..|     ||.......:||:   |.|   :|.|      |..|.|.....|....|
  Rat   612 IHYLAEGGSGN-----RSVTDIYATARQH---PLY---KLSP------GTTYHVCVLAANRAGLS 659

  Fly   715 QPQQTQQSTLLHSYTVIDSLNKSFLPGLGL----GVLVTSVLVL---IW 756
            |||.:.......::|...|   |.:...||    |:|:.|.|||   :|
  Rat   660 QPQTSGWGRSCATFTTKPS---SVVIFWGLCTASGLLLVSTLVLSVCLW 705

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lrt	NP_001286640.1	LRR	175..582	CDD:443914	100/472 (21%)
		leucine-rich repeat	179..199	CDD:275378	4/19 (21%)
		leucine-rich repeat	200..223	CDD:275380	5/22 (23%)
		leucine-rich repeat	225..248	CDD:275380	7/22 (32%)
		leucine-rich repeat	249..272	CDD:275380	6/22 (27%)
		leucine-rich repeat	273..296	CDD:275380	7/22 (32%)
		leucine-rich repeat	297..322	CDD:275380	7/24 (29%)
		leucine-rich repeat	323..347	CDD:275380	4/23 (17%)
		leucine-rich repeat	348..371	CDD:275380	5/22 (23%)
		leucine-rich repeat	372..395	CDD:275380	7/23 (30%)
		leucine-rich repeat	396..419	CDD:275380	0/22 (0%)
		leucine-rich repeat	420..443	CDD:275380	7/25 (28%)
		leucine-rich repeat	444..467	CDD:275380	4/22 (18%)
Lrrn4	NP_001417380.1	None