DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lrt and LRRN4

DIOPT Version :9

Sequence 1:	NP_001286640.1	Gene:	Lrt / 37342	FlyBaseID:	FBgn0034540	Length:	830	Species:	Drosophila melanogaster
Sequence 2:	NP_689824.2	Gene:	LRRN4 / 164312	HGNCID:	16208	Length:	740	Species:	Homo sapiens

Alignment Length:	481	Identity:	120/481 - (24%)
Similarity:	174/481 - (36%)	Gaps:	137/481 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   318 SQCLSLRQLDLQANNLNGPLSEQTLPGM--RNLESLNLNRNLIKSIQNKALANFSRLVSLSLRHN 380
            |.|..|...|..|..|.....|: |||.  |.|.||:.:.||::::....|.:..:|..|:||||
Human    46 SPCEGLPAADATALTLANRNLER-LPGCLPRTLRSLDASHNLLRALSTSELGHLEQLQVLTLRHN 109

  Fly   381 QIDVLQDHAFFGLG---ALDSLDLSYNGIVAISSASLQHLSRLTVLDLTHNFLRALTSDLIAPLP 442
            :|..|:    :|.|   .|.:||||||.:.|:...:...||.|..|.|..|.||||.....|..|
Human   110 RIAALR----WGPGGPAGLHTLDLSYNQLAALPPCTGPALSSLRALALAGNPLRALQPRAFACFP 170

  Fly   443 SLRELRLAGNDISIVARNAMDGARE-------------LESLQMQENPLSCDCSIRPFAEWLQES 494
            :|:.|.|:   .:.:.|.|..|..|             ||.|.:....|.     |..:.|:::.
Human   171 ALQLLNLS---CTALGRGAQGGIAEAAFAGEDGAPLVTLEVLDLSGTFLE-----RVESGWIRDL 227

  Fly   495 QLHSSLSASCVTPPR---LEGAPLLQVP-VETLSC-DMDNVEKDNANIMQ---HLETLAKPN--- 548
            ...:||....:  ||   |||......| ::.|.| |...:.....:|.|   ||:.|...|
Human   228 PKLTSLYLRKM--PRLTTLEGDIFKMTPNLQQLDCQDSPALASVATHIFQDTPHLQVLLFQNCNL 290

  Fly   549 --------QTSPIKDLSEEIILHELHFSTDYGLILTWLLNLSKK-------DYMCDAIFVYKEEH 598
                    .:|.:  ||..:..:.|..|.|    |:|||..:|:       |.||
Human   291 SSFPPWTLDSSQV--LSINLFGNPLTCSCD----LSWLLTDAKRTVLSRAADTMC---------- 339

  Fly   599 INEILIDNSPIHCESKVVNGQNTVSVIVPDSSSLEIGESYRFCLVMIQEQKPDSELNIGCSNITR 663
                    :|....|.            |.|:||.:.:....|       :.|....:|.|:...
Human   340 --------APAAGSSG------------PFSASLSLSQLPGVC-------QSDQSTTLGASHPPC 377

  Fly   664 LERS--------SPGAVPVSR------QYQRRPYYNANELKPEVVHDAGEDYQVNQRRFNSVVGS 714
            ..||        :|.|.|.:|      ...:.|...:..:......||.|             |:
Human   378 FNRSTYAQGTTVAPSAAPATRPAGDQQSVSKAPNVGSRTIAAWPHSDARE-------------GT 429

  Fly   715 QPQQTQQSTLLHSYTVIDSLNKSFLP 740
            .| .|..|...||       |.|..|
Human   430 AP-STTNSVAGHS-------NSSVFP 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrt	NP_001286640.1	LRR_RI	<151..334	CDD:238064	5/15 (33%)
		leucine-rich repeat	179..199	CDD:275378
		leucine-rich repeat	200..223	CDD:275380
		leucine-rich repeat	225..248	CDD:275380
		LRR_8	249..307	CDD:290566
		leucine-rich repeat	249..272	CDD:275380
		LRR_RI	<270..479	CDD:238064	57/178 (32%)
		leucine-rich repeat	273..296	CDD:275380
		leucine-rich repeat	297..322	CDD:275380	2/3 (67%)
		LRR_8	322..382	CDD:290566	21/61 (34%)
		leucine-rich repeat	323..347	CDD:275380	8/25 (32%)
		leucine-rich repeat	348..371	CDD:275380	6/22 (27%)
		LRR_8	370..428	CDD:290566	23/60 (38%)
		leucine-rich repeat	372..395	CDD:275380	10/25 (40%)
		leucine-rich repeat	396..419	CDD:275380	9/22 (41%)
		LRR_8	418..478	CDD:290566	21/72 (29%)
		leucine-rich repeat	420..443	CDD:275380	9/22 (41%)
		leucine-rich repeat	444..467	CDD:275380	6/22 (27%)
		LRRCT	476..526	CDD:214507	13/54 (24%)
LRRN4	NP_689824.2	LRR 1	51..74		8/23 (35%)
		LRR_RI	<69..213	CDD:238064	50/150 (33%)
		LRR_8	75..134	CDD:290566	24/62 (39%)
		LRR 2	75..97		7/21 (33%)
		leucine-rich repeat	77..100	CDD:275380	6/22 (27%)
		LRR 3	98..123		10/28 (36%)
		LRR_8	123..178	CDD:290566	22/54 (41%)
		leucine-rich repeat	124..147	CDD:275380	9/22 (41%)
		LRR 4	125..144		7/18 (39%)
		LRR 5	145..168		10/22 (45%)
		leucine-rich repeat	148..171	CDD:275380	9/22 (41%)
		LRR_8	170..236	CDD:290566	16/73 (22%)
		leucine-rich repeat	172..205	CDD:275380	7/35 (20%)
		LRR 6	174..197		6/25 (24%)
		LRR 7	203..226		6/27 (22%)
		leucine-rich repeat	206..229	CDD:275380	6/27 (22%)
		LRR	<224..>311	CDD:227223	20/90 (22%)
		LRR 8	228..251		7/24 (29%)
		leucine-rich repeat	230..254	CDD:275380	7/25 (28%)
		LRR 9	253..276		5/22 (23%)
		leucine-rich repeat	255..279	CDD:275380	5/23 (22%)
		LRR 10	277..300		4/22 (18%)
		leucine-rich repeat	280..303	CDD:275380	4/22 (18%)
		PHA03255	313..>491	CDD:165513	40/197 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	389..517		17/80 (21%)
		FN3	580..676	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910