DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lrt and Islr2

DIOPT Version :9

Sequence 1:NP_001286640.1 Gene:Lrt / 37342 FlyBaseID:FBgn0034540 Length:830 Species:Drosophila melanogaster
Sequence 2:XP_003750572.2 Gene:Islr2 / 100910729 RGDID:6497037 Length:746 Species:Rattus norvegicus


Alignment Length:504 Identity:118/504 - (23%)
Similarity:191/504 - (37%) Gaps:122/504 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   342 LPGMRNLESLNLNRNLIKSIQNKALANFSRLVSLSLRHNQIDVLQDHAFFGLGALDSLDLSYNGI 406
            ||.  |:.:|:|:.|.|..::..|..|.:::.||.|.|:::..::..|...|..|.:||||:|.|
  Rat    50 LPA--NVTTLSLSANKITVLRRGAFVNVTQVTSLWLAHSEVRTVESGALAVLSQLKNLDLSHNLI 112

  Fly   407 VAISSASLQHLSRLTVLDLTHNFLRALTSDLIAPLPSLRELRLAGNDISIVARNAMDGARELESL 471
            .....:.|::||.|.:|.:.||.|.:|..|.:..||.||.||:..|.:..:.....|....|..|
  Rat   113 SNFPWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLEPGTFDALSALSHL 177

  Fly   472 QMQENPLSCDCSIRPFAEWLQ--ESQLHSSL----SASCVTPPRLEGAPLLQVPVETLSCDMDNV 530
            |:..||..|.|.:    .|||  .:....||    |.:|.:||.|:|.|:.::|  .|.|...:|
  Rat   178 QLYHNPFHCSCGL----VWLQAWAASTRVSLPEPDSIACASPPELQGVPVHRLP--ALPCAPPSV 236

  Fly   531 EKDNANIMQHLETLAKPNQTSPIKDLSE--EIILH---ELHFSTDYGLILTWLLNLSKKDYMCDA 590
            ...           |:|...:|...|..  ..:||   |.|.:..    |.|.|.:.....:...
  Rat   237 RLS-----------AEPPPEAPGTPLRAGLSFLLHCVAEGHPTPR----LQWQLQIPGGTVVLVP 286

  Fly   591 IFVYKEEHINEILID-------NSPIHCES-------------------KVVNGQNTVSVIVPDS 629
            ..:.|||...|.:.|       :.|...|:                   .:.||    |::||..
  Rat   287 PVLSKEEDGGEKVDDGEGDGDEDQPTQTEAPTPTPAPAWPAPPATPRFLALANG----SLLVPLL 347

  Fly   630 SSLEIGESYRFCLVMIQEQKPDSELNIGCSNITRLERSSPGAVPVSRQYQRRPYYNANELKPEVV 694
            |:.|.|         |...:..:||.   :|.|.|..:...|.|..       :......:|:..
  Rat   348 SAKEAG---------IYTCRAHNELG---TNSTSLRVTVAAAGPPK-------HAPGTGEEPDAQ 393

  Fly   695 HDAGEDYQVNQRRFNSVVGSQPQQTQQSTLLHSYTVIDSLNKSFLPGLGLGVLVTSVLVLIWGAT 759
            ....|.....:.|.|||:..:|:...:                     |.|:...|:|    |.|
  Rat   394 APTSERKATTKGRSNSVLPFKPEGKTK---------------------GQGLARVSIL----GET 433

  Fly   760 --RIRQTGGSSGGGGR------------NGDSIDSNSSSMHNNNNNSRP 794
              .:.:|......||:            :||.....|:...|.:::.:|
  Rat   434 EAELEETDEEEQMGGQIPADPMGEKHCGHGDPSRYVSNHAFNQSSDLKP 482

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LrtNP_001286640.1 LRR_RI <151..334 CDD:238064
leucine-rich repeat 179..199 CDD:275378
leucine-rich repeat 200..223 CDD:275380
leucine-rich repeat 225..248 CDD:275380
LRR_8 249..307 CDD:290566
leucine-rich repeat 249..272 CDD:275380
LRR_RI <270..479 CDD:238064 45/136 (33%)
leucine-rich repeat 273..296 CDD:275380
leucine-rich repeat 297..322 CDD:275380
LRR_8 322..382 CDD:290566 13/39 (33%)
leucine-rich repeat 323..347 CDD:275380 2/4 (50%)
leucine-rich repeat 348..371 CDD:275380 6/22 (27%)
LRR_8 370..428 CDD:290566 18/57 (32%)
leucine-rich repeat 372..395 CDD:275380 6/22 (27%)
leucine-rich repeat 396..419 CDD:275380 9/22 (41%)
LRR_8 418..478 CDD:290566 20/59 (34%)
leucine-rich repeat 420..443 CDD:275380 8/22 (36%)
leucine-rich repeat 444..467 CDD:275380 6/22 (27%)
LRRCT 476..526 CDD:214507 18/55 (33%)
Islr2XP_003750572.2 leucine-rich repeat 37..53 CDD:275380 2/4 (50%)
leucine-rich repeat 54..77 CDD:275380 6/22 (27%)
leucine-rich repeat 78..101 CDD:275380 6/22 (27%)
LRR_8 100..160 CDD:404697 24/59 (41%)
leucine-rich repeat 102..125 CDD:275380 9/22 (41%)
leucine-rich repeat 126..149 CDD:275380 8/22 (36%)
leucine-rich repeat 150..173 CDD:275380 6/22 (27%)
PCC 155..>229 CDD:188093 22/79 (28%)
Ig 249..374 CDD:416386 29/144 (20%)
Ig strand B 257..264 CDD:409353 2/6 (33%)
Ig strand C 270..278 CDD:409353 3/11 (27%)
Ig strand C' 280..287 CDD:409353 0/6 (0%)
Ig strand D 333..337 CDD:409353 0/3 (0%)
Ig strand E 340..345 CDD:409353 2/8 (25%)
Ig strand F 353..361 CDD:409353 2/16 (13%)
Ig strand G 364..374 CDD:409353 3/12 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24366
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
22.010

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