Protein Alignment Lrt and islr2

DIOPT Version :10

• Sequence 1: NP_001286640.1
• Gene: Lrt / 37342
• FlyBaseID: FBgn0034540
• Length: 830
• Species: Drosophila melanogaster
• Sequence 2: NP_001120371.1
• Gene: islr2 / 100145445
• XenbaseID: XB-GENE-5920691
• Length: 691
• Species: Xenopus tropicalis
• Alignment Length: 527
• Identity: 106/527 - (20%)
• Similarity: 188/527 - (35%)
• Gaps: 136/527 - (25%)

  Fly   347 NLESLNLNRNLIKSIQNKALANFSRLVSLSLRHNQIDVLQDHAFFGLGALDSLDLSYNGIVAISS 411
            |:.:|:|:.|.|.|::........::.||.|.||:|..:::.|...:..|.:||:|:|.:|....
 Frog    52 NVTTLSLSANKITSLKKSDFIGVPQVTSLWLAHNEISEIEEGALATMVNLKNLDVSHNLLVEFPW 116

  Fly   412 ASLQHLSRLTVLDLTHNFLRALTSDLIAPLPSLRELRLAGNDISIVARNAMDGARELESLQMQEN 476
            ..|..||.|.::.:.:|.:..|..|....|..|:.||:..|..|::..........|..:|:..|
 Frog   117 RDLASLSALQLIKMNNNRMVNLPRDAFQNLNELKSLRINNNQFSVIQEGTFKPLISLSHIQIYNN 181

  Fly   477 PLSCDCSIRPFAEWLQESQ--LHSSLSASCVTPPRLEGAPLLQVPVETLSCDMDNVE------KD 533
            |..|.||:....:|.:|:|  :....:.:|.:|..|:|.|:.::|  .|.|:...|:      .|
 Frog   182 PFHCSCSLMWLKKWAEEAQFSVPEKDNIACSSPEELKGTPISKIP--DLPCEAPTVQLSYYPNLD 244

  Fly   534 NANIMQ----HLETLA----KPNQTSPIKDLSEEIILHELHFSTDYGLILTWLLNLSKKDYMCDA 590
            :..:..    .|:.||    :|.....:::.::|         |:....:...:..|.|.....:
 Frog   245 STELYDGFTLSLQCLASGIPQPTIKWKVRNATQE---------TEIKQPVDGQVKGSAKSQKSSS 300

  Fly   591 IFVYKE-----EHINEILIDNSPIHCESKVVNGQNTVSVIVPDSSSLEIGESYRFCLVMIQEQKP 650
            ..|::.     .|:::.:  .....||.....|.:..||      ::.:..|.::...:|:|...
 Frog   301 FLVFQNGTLVIPHLSKKM--EGTYICEGNNEMGSSQASV------NVSVAGSQKYPTKVIEEPTK 357

  Fly   651 DSELNIGCSNITRLERSSPGAVPVSRQYQRRPYYNANELKPEVVHDAGEDYQVNQRRFNSVVGSQ 715
            ...|.         |...|| |..|                    |.|          |||:  :
 Frog   358 SKSLP---------ENKKPG-VKTS--------------------DTG----------NSVI--K 380

  Fly   716 PQQTQQSTLLHSYTVIDSLNKSFLP--------GLGLGVLVTSVLVLIWGATRIRQTGGSSGGGG 772
            |.::::.            .|..:|        |..|||              ...|...|....
 Frog   381 PDKSEEK------------GKPLIPTEQPFMTGGNKLGV--------------PEHTDHPSASDK 419

  Fly   773 RNGDSIDSNSSSMH--NNNNNSRPGT---------------PTATTCY---AASDHIARLADAEN 817
            :.|.|......|.|  |.:.|.:|.|               ....|.|   ..:||:..|...:.
 Frog   420 KCGPSTGGQHISNHAFNESTNLKPHTFELGVIALDVSEKDAKVQITPYHNRQGNDHLRMLYLCQE 484

  Fly   818 GTRYLKL 824
            |...|.|
 Frog   485 GANGLSL 491

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lrt	NP_001286640.1	LRR	175..582	CDD:443914	58/250 (23%)
		leucine-rich repeat	179..199	CDD:275378
		leucine-rich repeat	200..223	CDD:275380
		leucine-rich repeat	225..248	CDD:275380
		leucine-rich repeat	249..272	CDD:275380
		leucine-rich repeat	273..296	CDD:275380
		leucine-rich repeat	297..322	CDD:275380
		leucine-rich repeat	323..347	CDD:275380	106/527 (20%)
		leucine-rich repeat	348..371	CDD:275380	5/22 (23%)
		leucine-rich repeat	372..395	CDD:275380	7/22 (32%)
		leucine-rich repeat	396..419	CDD:275380	8/22 (36%)
		leucine-rich repeat	420..443	CDD:275380	5/22 (23%)
		leucine-rich repeat	444..467	CDD:275380	5/22 (23%)
islr2	NP_001120371.1	LRR	<36..>228	CDD:443914	48/177 (27%)
		leucine-rich repeat	36..52	CDD:275380	106/527 (20%)
		leucine-rich repeat	53..76	CDD:275380	5/22 (23%)
		leucine-rich repeat	77..100	CDD:275380	7/22 (32%)
		leucine-rich repeat	101..124	CDD:275380	8/22 (36%)
		leucine-rich repeat	125..148	CDD:275380	5/22 (23%)
		leucine-rich repeat	149..172	CDD:275380	5/22 (23%)
		Ig	251..332	CDD:472250	12/91 (13%)
		Ig strand B	254..258	CDD:409353	1/3 (33%)
		Ig strand C	267..271	CDD:409353	0/3 (0%)
		Ig strand E	307..311	CDD:409353	0/3 (0%)
		Ig strand F	321..326	CDD:409353	1/4 (25%)