DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lrt and flrt1b

DIOPT Version :9

Sequence 1:NP_001286640.1 Gene:Lrt / 37342 FlyBaseID:FBgn0034540 Length:830 Species:Drosophila melanogaster
Sequence 2:XP_005169675.1 Gene:flrt1b / 100144397 ZFINID:ZDB-GENE-080327-6 Length:715 Species:Danio rerio


Alignment Length:578 Identity:143/578 - (24%)
Similarity:209/578 - (36%) Gaps:158/578 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   242 ALSTLSALERLDLANNKIKALGTADFVG-----------------------------LTSLVYLE 277
            |.:|.:|.|         .|||.|:..|                             ||:.| |.
Zfish    30 AAATAAAAE---------AALGEAELQGEVPCPSACRCDDGFIYCNDRGLTLIPPLPLTAAV-LY 84

  Fly   278 LSNNQISSISQRTFVNLR-KLEVLKLGGNRLGDYAQSLRSLSQCLSLRQLDLQANNLNGPLSEQT 341
            |.||:|.:....|.:..| .:.|:.|..|.|.|:...|..     |||:|.||.||:. .|....
Zfish    85 LQNNRIDNAGLPTSLERRLTVRVVYLYDNELDDFPTHLPP-----SLRELHLQDNNIR-TLPRSA 143

  Fly   342 LPGMRNLESLNLNRNLIK--SIQNKALANFS--RLVSLSLRH-------------------NQID 383
            |..:..||.|:::.|.|.  ||::||..|..  ||:.||..|                   |:|.
Zfish   144 LARLPLLEKLHMDDNSISTVSIEDKAFTNNPRLRLLFLSRNHLSSIPSGLPASLEELRLDDNRIS 208

  Fly   384 VLQDHAFFGLGALDSLDLSYNGIV--AISSASLQHLSRLTVLDLTHNFLRALTSDLIAPLPSLRE 446
            .:..|||.||.:|..|.|..|.:.  .|:..:...||.||.|.|..|.|:|...:    ||||..
Zfish   209 TIPTHAFRGLSSLRRLFLDGNLLANQRIADDTFSRLSNLTELSLVRNSLQAPPLN----LPSLHL 269

  Fly   447 LR--LAGNDISIVARNAMDGARELESLQ------------------------MQENPLSCDCSIR 485
            ||  |..|.|:.:.|.::||.|.|:.|.                        ::.||..|.|::|
Zfish   270 LRLYLQDNAIAHMPRGSLDGMRRLQKLDISGNNLTTLPRGLFKDLDSLSQLLVRGNPWYCGCNLR 334

  Fly   486 PFAEWLQESQLHSSLSA---SCVTPPRLEGAPLLQVPVETLSCDMDNVEKDNANIMQHLETLAK- 546
            ...:||.|.  .||::.   :|..|.||.|..|..:..:...|:   |..|.|..|...|...| 
Zfish   335 WLHDWLHER--GSSVTVRGLTCHAPERLRGMALRDLSSQLEDCE---VTVDAAGGMVGNEVAKKE 394

  Fly   547 --------PNQTSPIKDLSEEIILHEL---HFSTDYGL--------ILTWLLNLSKKDYMCDAIF 592
                    |..|:|.........|...   |..:|.|.        .::..|.:|.|....:.:.
Zfish   395 KGYFPTQPPATTTPPLPQGSLFTLRSRRPGHKYSDMGQDSLGGGNGFVSKSLLISVKPLTPETVH 459

  Fly   593 VYKEE-------HINEILIDNSPIHCESKVVNGQNTVSVIVPDS-----SSLEIGESYRFCLVMI 645
            :..:.       .::.:.:.|||       ..|..|.:::..|.     :.|:...||..|||.:
Zfish   460 ITWQAAQPVPSFRLSWLRLGNSP-------AMGSITETLVPGDRREYLLTQLQPQSSYIICLVPL 517

  Fly   646 --QEQKPDSELNIGCSNI-TRLERSSPGAVPVSRQYQRRPYYNANELKPEVVHDAGED 700
              .:.|..|....|..|| |..|...|...........:|..:.:.       |.|.|
Zfish   518 AGNDGKRTSFTATGGLNINTNSEHEHPACAKTETDPLEQPMSDQDS-------DRGTD 568

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LrtNP_001286640.1 LRR_RI <151..334 CDD:238064 33/121 (27%)
leucine-rich repeat 179..199 CDD:275378
leucine-rich repeat 200..223 CDD:275380
leucine-rich repeat 225..248 CDD:275380 2/5 (40%)
LRR_8 249..307 CDD:290566 19/87 (22%)
leucine-rich repeat 249..272 CDD:275380 7/51 (14%)
LRR_RI <270..479 CDD:238064 79/260 (30%)
leucine-rich repeat 273..296 CDD:275380 8/23 (35%)
leucine-rich repeat 297..322 CDD:275380 6/24 (25%)
LRR_8 322..382 CDD:290566 26/82 (32%)
leucine-rich repeat 323..347 CDD:275380 9/23 (39%)
leucine-rich repeat 348..371 CDD:275380 10/26 (38%)
LRR_8 370..428 CDD:290566 23/80 (29%)
leucine-rich repeat 372..395 CDD:275380 11/41 (27%)
leucine-rich repeat 396..419 CDD:275380 6/24 (25%)
LRR_8 418..478 CDD:290566 24/85 (28%)
leucine-rich repeat 420..443 CDD:275380 8/22 (36%)
leucine-rich repeat 444..467 CDD:275380 9/24 (38%)
LRRCT 476..526 CDD:214507 16/52 (31%)
flrt1bXP_005169675.1 LRRNT 51..77 CDD:214470 0/25 (0%)
leucine-rich repeat 82..104 CDD:275378 8/22 (36%)
leucine-rich repeat 105..125 CDD:275380 6/24 (25%)
LRR_RI <120..305 CDD:238064 62/194 (32%)
LRR_8 124..186 CDD:290566 24/67 (36%)
leucine-rich repeat 126..149 CDD:275380 9/23 (39%)
leucine-rich repeat 150..175 CDD:275380 10/24 (42%)
LRR_8 174..231 CDD:290566 16/56 (29%)
leucine-rich repeat 176..196 CDD:275380 5/19 (26%)
leucine-rich repeat 197..220 CDD:275380 7/22 (32%)
leucine-rich repeat 221..246 CDD:275380 6/24 (25%)
leucine-rich repeat 247..268 CDD:275380 10/24 (42%)
LRR_8 268..326 CDD:290566 11/57 (19%)
leucine-rich repeat 269..292 CDD:275380 8/22 (36%)
leucine-rich repeat 293..316 CDD:275380 2/22 (9%)
LRRCT 325..375 CDD:214507 16/51 (31%)
fn3 448..515 CDD:278470 12/73 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
10.960

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