DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DMAP1 and SWC4

DIOPT Version :9

Sequence 1:	NP_611503.1	Gene:	DMAP1 / 37339	FlyBaseID:	FBgn0034537	Length:	433	Species:	Drosophila melanogaster
Sequence 2:	NP_011516.1	Gene:	SWC4 / 852885	SGDID:	S000003234	Length:	476	Species:	Saccharomyces cerevisiae

Alignment Length:	507	Identity:	117/507 - (23%)
Similarity:	210/507 - (41%)	Gaps:	140/507 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SADVRDILDM-ERANTPEVTRDSFLATKKRNFERTKTASRRPE----GMHREVFALLYTDKKDAP 61
            |:|:.|:|:: :::.:|         |..:....:.:|:.||:    ||.||:|.||   .::.|
Yeast     3 SSDIFDVLNIKQKSRSP---------TNGQVSVPSSSAANRPKPQVTGMQRELFNLL---GENQP 55

  Fly    62 PLLPTDTALGIGAGYKETKARLGMKKVRKWEWAPFSNPARNDSAVFHHWKR-----VTDNSTDYP 121
            |::     :..|..:||  ..|...|...|.:..|.   .|:|....||.:     :.|...:.|
Yeast    56 PVV-----IKSGNNFKE--KMLSTSKPSPWSFVEFK---ANNSVTLRHWVKGSKELIGDTPKESP 110

  Fly   122 FAKFNKQLEVPSYTMTEYNAHLRNN-------------------------INNWSKVQTDHLFDL 161
            ::|||:.|.:||:|..||.|.:..|                         .|:||..:.::||:|
Yeast   111 YSKFNQHLSIPSFTKEEYEAFMNENEGTQKSVESEKNHNENFTNEKKDESKNSWSFEEIEYLFNL 175

  Fly   162 ARRFDLRFIVMADRWNRQQHGTKTVEELKERYYEVVALLAKAKNQTSE-KKVFVYDVEHERRRKE 225
            .:::|||:.::.||::  .:.::|:|:|||::|.......||.:.::. .....:..|.|..||:
Yeast   176 CKKYDLRWFLIFDRYS--YNNSRTLEDLKEKFYYTCRNYFKASDPSNPLLSSLNFSAEKEIERKK 238

  Fly   226 QLEKLFKRTTQQVEEENMLINEMKKIEARKK----ERER----------------------KTQD 264
            .|::|..|:..::.||..|:.|.||.|...|    |||.                      .:|.
Yeast   239 YLQRLLSRSAAEIAEEEALVVESKKFEMAAKRTLAERESLLRLLDSPHSDQTITQYLTSQGMSQL 303

  Fly   265 LQKLISQADQQNEHASNTP--------------------STRKYEKK--LHKKKVHQQPRPSRV- 306
            ...|::...::.:|..|.|                    :.:|.|.|  |..||..:|.:..:.
Yeast   304 YNALLADKTRKRKHDLNIPENPWMKQQQQFAQHRQLQQLNVKKSEVKENLSPKKTKRQRQEMQTA 368

  Fly   307 -----DSV--------VNAIEIGSSG-IKFADLRGSGVSLRSQRMKLPANIGQRKVKALEQAIQE 357
                 :|.        .|:.|..:.| |...:....||.|||.::.......|.|:.|:   :||
Yeast   369 LKRKSESAYAEQLLKDFNSDERKALGVITHGEKLSPGVYLRSTKLSTFKPALQNKILAI---LQE 430

  Fly   358 FKVDPAPPPTEDICTSFNELRSDMVLLCELRTALSTCVYEMESLKH--QYEA 407
            ..:     |:..:..||:.:.....||.::.|.:       :..||  :|||
Yeast   431 LSL-----PSRPVMPSFDVMERQEELLKKINTLI-------DLKKHVDKYEA 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DMAP1	NP_611503.1	SANT_DAMP1_like	120..200	CDD:318509	29/104 (28%)
DMAP1	NP_611503.1	DMAP1	240..412	CDD:310242	49/233 (21%)
SWC4	NP_011516.1	SANT_DAMP1_like	109..213	CDD:406645	29/105 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345598
Domainoid	1	1.000	59	1.000	Domainoid score	I2602
eggNOG	1	0.900	-	-		E1_KOG2656
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	105	1.000	Inparanoid score	I1423
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005191
OrthoInspector	1	1.000	-	-		oto99561
orthoMCL	1	0.900	-	-		OOG6_102680
Panther	1	1.100	-	-	LDO	PTHR12855
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1419
SonicParanoid	1	1.000	-	-		X3704
TreeFam	1	0.960	-	-
	13	12.780