DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DMAP1 and DMAP1

DIOPT Version :9

Sequence 1:	NP_611503.1	Gene:	DMAP1 / 37339	FlyBaseID:	FBgn0034537	Length:	433	Species:	Drosophila melanogaster
Sequence 2:	NP_001029195.1	Gene:	DMAP1 / 55929	HGNCID:	18291	Length:	467	Species:	Homo sapiens

Alignment Length:	445	Identity:	215/445 - (48%)
Similarity:	300/445 - (67%)	Gaps:	45/445 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ADVRDILDM-----ERANTPEVTRDSFLATKKRNFERTKTAS-RRPEGMHREVFALLYTDKKDAP 61
            |||||||::     :.|:.....:|.....||::.:.::|.: :|||||||||:||||:||||||
Human     5 ADVRDILELGGPEGDAASGTISKKDIINPDKKKSKKSSETLTFKRPEGMHREVYALLYSDKKDAP 69

  Fly    62 PLLPTDTALGIGAGYKETKARLGMKKVRKWEWAPFSNPARNDSAVFHHWKRVTDNSTDYPFAKFN 126
            ||||:||    |.||:..||:||.||||.|:|.||:||||.|.|:|.||:|..:...|||||:||
Human    70 PLLPSDT----GQGYRTVKAKLGSKKVRPWKWMPFTNPARKDGAMFFHWRRAAEEGKDYPFARFN 130

  Fly   127 KQLEVPSYTMTEYNAHLRNNINNWSKVQTDHLFDLARRFDLRFIVMADRWNRQQHGTKTVEELKE 191
            |.::||.|:..||..:|.::.  |:|.:|||||||:|||||||:|:.||::.||...::||:|||
Human   131 KTVQVPVYSEQEYQLYLHDDA--WTKAETDHLFDLSRRFDLRFVVIHDRYDHQQFKKRSVEDLKE 193

  Fly   192 RYYEVVALLAKAKN-QTSEKKVFVYDVEHERRRKEQLEKLFKRTTQQVEEENMLINEMKKIEARK 255
            |||.:.|.||..:. ..::.|:.|:|..||||||||||:|:.||.:||.||..|:.|::||||||
Human   194 RYYHICAKLANVRAVPGTDLKIPVFDAGHERRRKEQLERLYNRTPEQVAEEEYLLQELRKIEARK 258

  Fly   256 KERERKTQDLQKLISQADQQNEHASNTPSTRKYEKKLHKKKVHQQPRPSRVDSVVNAIEIGSSGI 320
            ||||:::|||||||:.||       .|...|:.|:|..|||:     |.:.::...|:. .::||
Human   259 KEREKRSQDLQKLITAAD-------TTAEQRRTERKAPKKKL-----PQKKEAEKPAVP-ETAGI 310

  Fly   321 KFADLRGSGVSLRSQRMKLPANIGQRKVKALEQAIQEFKVDPAPPPTEDICTSFNELRSDMVLLC 385
            ||.|.:.:||:|||||||||:::||:|:|||||.:.|..|:.:|.|||::...|||||||:|||.
Human   311 KFPDFKSAGVTLRSQRMKLPSSVGQKKIKALEQMLLELGVELSPTPTEELVHMFNELRSDLVLLY 375

  Fly   386 ELRTALSTCVYEMESLKHQYEAAC--------------PGKTLNIPPSLVPIKTE 426
            ||:.|.:.|.||::.|:|::||..              ||     |.|..|..||
Human   376 ELKQACANCEYELQMLRHRHEALARAGVLGGPATPASGPG-----PASAEPAVTE 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DMAP1	NP_611503.1	SANT_DAMP1_like	120..200	CDD:318509	43/79 (54%)
DMAP1	NP_611503.1	DMAP1	240..412	CDD:310242	83/185 (45%)
DMAP1	NP_001029195.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..48		16/48 (33%)
		SANT_DAMP1_like	124..203	CDD:406645	41/78 (53%)
		DMAP1	243..402	CDD:398903	77/158 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	258..305		20/46 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	404..467		10/39 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156961
Domainoid	1	1.000	155	1.000	Domainoid score	I4234
eggNOG	1	0.900	-	-		E1_KOG2656
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41311
Inparanoid	1	1.050	402	1.000	Inparanoid score	I1927
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59227
OrthoDB	1	1.010	-	-		D474387at33208
OrthoFinder	1	1.000	-	-		FOG0005191
OrthoInspector	1	1.000	-	-		oto89844
orthoMCL	1	0.900	-	-		OOG6_102680
Panther	1	1.100	-	-	LDO	PTHR12855
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3704
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.770