DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment maf-S and MAF

DIOPT Version :9

Sequence 1:	NP_001286639.1	Gene:	maf-S / 37336	FlyBaseID:	FBgn0034534	Length:	137	Species:	Drosophila melanogaster
Sequence 2:	NP_005351.2	Gene:	MAF / 4094	HGNCID:	6776	Length:	403	Species:	Homo sapiens

Alignment Length:	93	Identity:	41/93 - (44%)
Similarity:	72/93 - (77%)	Gaps:	2/93 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 TDDDLVSISVRDLNRTLKMRGLNREEIVRMKQRRRTLKNRGYAASCRIKRIEQKDELETKKSYEW 92
            :|:.||::|||:|||  ::||:::||::|:||:||||||||||.|||.||::|:..||::|:...
Human   262 SDEQLVTMSVRELNR--QLRGVSKEEVIRLKQKRRTLKNRGYAQSCRFKRVQQRHVLESEKNQLL 324

  Fly    93 TELEQMHEDNEQVRREVSNWKNKYKALL 120
            .:::.:.::..::.||...:|.||:.|:
Human   325 QQVDHLKQEISRLVRERDAYKEKYEKLV 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
maf-S	NP_001286639.1	bZIP_Maf_small	51..120	CDD:269865	29/68 (43%)
maf-S	NP_001286639.1	coiled coil	59..110	CDD:269865	22/50 (44%)
MAF	NP_005351.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	57..84
		Maf_N	86..119	CDD:400609
		Represses ARE-mediated transcription	126..373		41/93 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	175..222
		bZIP_Maf_large	283..351	CDD:269866	29/67 (43%)
		Basic motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	288..313		18/24 (75%)
		coiled coil	291..342	CDD:269866	22/50 (44%)
		Leucine-zipper. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	316..337		3/20 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	354..373
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143689
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1395389at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5055
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.780