DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment maf-S and Nrl

DIOPT Version :9

Sequence 1:	NP_001286639.1	Gene:	maf-S / 37336	FlyBaseID:	FBgn0034534	Length:	137	Species:	Drosophila melanogaster
Sequence 2:	NP_001129546.1	Gene:	Nrl / 18185	MGIID:	102567	Length:	237	Species:	Mus musculus

Alignment Length:	96	Identity:	42/96 - (43%)
Similarity:	67/96 - (69%)	Gaps:	7/96 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 IPD-ITDDDLVSISVRDLNRTLKMRGLNREEIVRMKQRRRTLKNRGYAASCRIKRIEQKDELETK 87
            :|: .:|..|||:|||:|||  ::||..|:|.:|:|||||||||||||.:||.||::|:..||.:
Mouse   128 LPERFSDAALVSMSVRELNR--QLRGCGRDEALRLKQRRRTLKNRGYAQACRSKRLQQRRGLEAE 190

  Fly    88 KSYEWTELEQMHEDNEQVRREVSNWKNKYKA 118
            ::....:|:.:..:..::.||    ::.|||
Mouse   191 RARLAAQLDALRAEVARLARE----RDLYKA 217

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
maf-S	NP_001286639.1	bZIP_Maf_small	51..120	CDD:269865	29/68 (43%)
maf-S	NP_001286639.1	coiled coil	59..110	CDD:269865	22/50 (44%)
Nrl	NP_001129546.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	26..64
		Minimal transactivation domain (MTD). /evidence=ECO:0000250\|UniProtKB:P54845	30..93
		Maf_N	67..101	CDD:285569
		bZIP_Maf_large	154..223	CDD:269866	29/68 (43%)
		coiled coil	154..223	CDD:269866	29/68 (43%)
		Basic motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	159..185		19/25 (76%)
		Leucine-zipper. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	187..208		3/20 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833880
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1395389at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.750