DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rig and MDV1

DIOPT Version :9

Sequence 1:	NP_611499.3	Gene:	rig / 37335	FlyBaseID:	FBgn0250850	Length:	1235	Species:	Drosophila melanogaster
Sequence 2:	NP_012423.1	Gene:	MDV1 / 853332	SGDID:	S000003648	Length:	714	Species:	Saccharomyces cerevisiae

Alignment Length:	789	Identity:	147/789 - (18%)
Similarity:	259/789 - (32%)	Gaps:	245/789 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 TTNSVLMSY----------LANG----NILSMDASDLVIYCVASNTYCRRSTFISPRNHQLTMVR 171
            ||.|..::|          |.|.    |:||...::      ||:|    |.|.....|...:..
Yeast    16 TTASAFLNYQKSNSNTQDVLTNNGPYKNLLSNTVNN------ASST----SYFYKRTEHGRFVKN 70

  Fly   172 CSPYNDNLFAVGTAMGNVLVCDLRKMNIVYKFHGHKAPICGLAW------REVPAAEDEKTNNLA 230
            .|...::::: .|..|:|.      .|   ||..:|.....|.:      .|:|..|..|::
Yeast    71 ASNTFEDIYS-KTRRGDVF------RN---KFTDNKTCFRMLTYISDDLLNEIPTKEGLKSD--- 122

  Fly   231 LSAEEWRSRNGGQEEKPKTKPPPLTKSKAAESDDPFDIYNFDHLEYEFGAPIAERRRKSSEDCGG 295
              |:......||:.|.       |.|:.:.:....|.       .::...||||...:::|....
Yeast   123 --ADGKLLTEGGENEN-------LRKNASKKETSLFQ-------GFKSYLPIAELAIENTERLNY 171

  Fly   296 EFVGLEKPAGAAVLDFVEACESVKAELLASRQEDKTQHVEV-TLHD---CEPTKPTGPLSDASTI 356
            :..|.....||             .::::...|....|.|: ...|   ..|...|..:|.:.:.
Yeast   172 DTNGTSGTVGA-------------KDVMSKTNERDEIHTELPNFQDSFLIPPGVETKKISSSYSP 223

  Fly   357 SNKNDASDSTEGSLEVIQYSSSSDDAVIVDGEA-----AKPKREVLHHI---------------- 400
            |.....|.:...|||.:....:|..:.|.|.|.     .:.|.::|..|
Yeast   224 SALKSFSQTLVNSLEFLNIQKNSTLSEIRDIEVEVENLRQKKEKLLGKIANIEQNQLLLEDNLKQ 288

  Fly   401 ----------YHQAEVHASGTPQTKSEPQSNLQVV--PAISAETISLTSVNSTHLETLLVSIDGD 453
                      |....:.|:.....:.:..|..:.:  .||..|.::..|::|.     ..::...
Yeast   289 IDDRLDFLEEYGLEVIEANSDENAEDDGMSERKALKNDAIRNEGVTTESISSE-----ASNLPPR 348

  Fly   454 EVMMIWNTNTGAHAGKNYSKSKTAGK-----LNNVYWLNNHVIVSLSRHQLFFWSVEFERKMLRY 513
            ....:.:.|:....|..|||||...:     ...:|.....:...:|.|..|...::|:......
Yeast   349 RRQQLRDDNSLNRLGAFYSKSKKRHRKSFPTFQQLYEPGTKIGSIMSTHDDFLTCLDFDAPFGTL 413

  Fly   514 KISKDKSHSCHLQDIVSFACDSSKEMIWLCRNNRQIGMMNPKTGRMADF--------YGTVAFGV 570
            ..:....|:..:.|:       ||:        .:||.:   .|.:|..        |||:..|.
Yeast   414 CTAGYLDHTVKIWDL-------SKQ--------NKIGEL---AGHLATINCMQINRDYGTLVTGG 460

  Fly   571 RAMA--------------------------ECP---------DDMNKIAL-------GCSDRRVA 593
            |..|                          :.|         |::..::|       |..||.:.
Yeast   461 RDAALKLWNLNLAQQLYQETQNLTSPTNHIDSPCVHTFEAHTDEVTALSLDPSFLVSGSQDRTIR 525

  Fly   594 FFDISK---LTTSCLPIDSVYVSSNVYCLAWSPNCLE----------------LAFGTFDGTVGI 639
            .:|:..   |.|..|...:|..:|....|:.|....:                ||.||.||.|.:
Yeast   526 QWDLRSGKCLQTIDLSFANVLTTSTNVDLSKSTLLTQRNERPSIGALQSFDAALATGTKDGVVRL 590

  Fly   640 LDVERMKVKTHLRT--PHKKEVYSLVWQDH-FIYFIVNRVLGFFDLRKSKIEPTIVNCISRPSYL 701
            .|:...||   :||  .|...:.||.:... .:....:|.:..:|||...:..  .:..|.| .|
Yeast   591 WDLRSGKV---IRTLKGHTDAITSLKFDSACLVTGSYDRTVRIWDLRTGLLNK--FHAYSAP-VL 649

  Fly   702 SI---RDSFLFVGTDDGLLQIHERDSGMEKSWSPFIRQSALFARYVTDIAWCPLDSNKFAVSGND 763
            |:   :::...|..|:..:||:  ||..::|||                  |       ...||:
Yeast   650 SLDLFQENAAVVVADEPSVQIY--DSEKDESWS------------------C-------VEQGNE 687

  Fly   764 RSVYVMEFQ 772
            .||..::::
Yeast   688 TSVSTVKYK 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rig	NP_611499.3	WD40	<80..>215	CDD:295369	24/107 (22%)
		WD40	80..>215	CDD:225201	24/107 (22%)
		WD40 repeat	116..160	CDD:293791	13/52 (25%)
		WD40 repeat	167..204	CDD:293791	6/36 (17%)
		WD40	434..821	CDD:225201	79/419 (19%)
		WD40	446..719	CDD:295369	65/352 (18%)
		WD40	613..874	CDD:295369	40/182 (22%)
		WD40 repeat	617..654	CDD:293791	14/54 (26%)
		WD40 repeat	659..691	CDD:293791	6/32 (19%)
		WD40 repeat	693..732	CDD:293791	12/41 (29%)
		WD40 repeat	744..785	CDD:293791	5/29 (17%)
		WD40 repeat	793..831	CDD:293791
		WD40 repeat	838..861	CDD:293791
MDV1	NP_012423.1	Mdv1	123..171	CDD:402923	12/61 (20%)
		WD40	397..713	CDD:238121	68/351 (19%)
		WD40 repeat	402..439	CDD:293791	7/54 (13%)
		WD40 repeat	444..499	CDD:293791	7/54 (13%)
		WD40 repeat	506..539	CDD:293791	7/32 (22%)
		WD40 repeat	546..603	CDD:293791	15/59 (25%)
		WD40 repeat	648..683	CDD:293791	12/61 (20%)
		WD40 repeat	690..712	CDD:293791	1/7 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4155
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900