DRSC/TRiP Functional Genomics Resources

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Protein Alignment rig and Apaf1

DIOPT Version :9

Sequence 1:NP_611499.3 Gene:rig / 37335 FlyBaseID:FBgn0250850 Length:1235 Species:Drosophila melanogaster
Sequence 2:NP_076469.1 Gene:Apaf1 / 78963 RGDID:620575 Length:1249 Species:Rattus norvegicus


Alignment Length:805 Identity:129/805 - (16%)
Similarity:228/805 - (28%) Gaps:398/805 - (49%)


- Green bases have known domain annotations that are detailed below.


  Fly    86 DLSVQVWDCALGEAVIGHKAHQHQHEARDVRVVHHT--TNSVLMSYLANGNILSMDASDLVIYCV 148
            |..|::||...|:.|     |.::..:..|...|.|  :|.:|::..:|.:.|.:  .||     
  Rat   678 DKKVKIWDSGTGKLV-----HTYEEHSEQVNCCHFTNKSNHLLLATGSNDSFLKL--WDL----- 730

  Fly   149 ASNTYCRRSTFISPRNHQLTMVRCSPYNDNLFAVGTAMGNVLVCDLRKMNIVYKFHGHKAPICGL 213
             :...||.:.|  ...:.:|..|.|| :|.|.|..:|.|.:.:.|:|                  
  Rat   731 -NQKECRNTMF--GHTNSVTHCRFSP-DDELLASCSADGTLKLWDVR------------------ 773

  Fly   214 AWREVPAAEDEKTNNLALSAEEWRSRNGGQEEKPKTKPPPLTKSKAAESDDPFDIYNFDHLEYEF 278
                              ||.|.:|.|                                      
  Rat   774 ------------------SANEKKSIN-------------------------------------- 782

  Fly   279 GAPIAERRRKSSEDCGGEFVGLEKPAGAAVLDFVEACESVKAELLASRQEDKTQHVEVTLHDCEP 343
                                                   ||...|:|  ||..:.|||.:..|  
  Rat   783 ---------------------------------------VKRFFLSS--EDPPEDVEVIVKCC-- 804

  Fly   344 TKPTGPLSDASTISNKNDASDSTEGSLEVIQYSSSSDDAVIVDGEAAKPKREVLHHIYHQAEVHA 408
                               |.|.:|            |.:||   |||.|..:|       ::|.
  Rat   805 -------------------SWSADG------------DRIIV---AAKNKVLLL-------DIHT 828

  Fly   409 SGTPQTKSEPQSNLQVVPAISAETISLTSVNSTHLETLLVSIDGDEVMMIWNTNTGAHAGKNYSK 473
            ||                                   ||..|           :||.|:...|..
  Rat   829 SG-----------------------------------LLTEI-----------HTGHHSTIQYCD 847

  Fly   474 SKTAGKLNNVYWLNNHVIVSLSRHQLFFWSVEFERKMLRYKISKDKSHSCHLQDIV------SF- 531
            ......|         .:::||::.:..|:::     .|.|::..:.|...:..::      || 
  Rat   848 FSPYDHL---------AVIALSQYCVELWNID-----SRVKVADCRGHLSWVHGVMFSPDGSSFL 898

  Fly   532 -ACDSSKEMIW----LCRNN-------------------------RQIGMMNPKTGRMADFYGTV 566
             |.|.....:|    :|:|:                         |.:.::..|||:: |:    
  Rat   899 TASDDQTIRVWETRKVCKNSAIVLKQEIDVVFQENEMMVLAVDNIRGLQLIAGKTGQI-DY---- 958

  Fly   567 AFGVRAMAECPDDMNKIALGCSDRRVAFFDISKLTTSCLPIDSVYVSSNVYCLAWSPNCLELAFG 631
                                                  ||      .:.|.|...||:...:|||
  Rat   959 --------------------------------------LP------EAQVSCCCLSPHLEYVAFG 979

  Fly   632 TFDGTVGILDVERMKVKTHLRTPHKKEVYSL-------------------VWQ---DHFIYFIVN 674
            ..:|.:.|:::...:|.:. ...|||.|..:                   ||.   :.:::...:
  Rat   980 DEEGAIKIIELPNNRVFSS-GIGHKKAVRHIQFTADGKTLISSSEDSVIQVWNWQTEEYVFLQAH 1043

  Fly   675 RVLGFFDLRKSKIEPTIVNCISRPSYLSIRDSFLFVGTDDGLLQIH-------ERDSGMEKSWSP 732
                         :.|:      ..:..:|||.|...:.||.:::.       |||         
  Rat  1044 -------------QETV------KDFRLLRDSRLLSWSFDGTVKVWNVITGRIERD--------- 1080

  Fly   733 FIRQSALFARYVTDIAWCPL--DSNKFAVSGNDRSVYVMEFQ-PTERNWKTLHTFTANTEKASIT 794
                   |..:...:..|.:  |:.||:.:..|::..:..|: |:..:....|.........|:.
  Rat  1081 -------FTCHQGTVLSCAISSDATKFSSTSADKTAKIWSFELPSPLHELKGHNSCVRCSAFSLD 1138

  Fly   795 SMRWSHTQKHLLLTFHIEGKVCLWN 819
            .:        ||.|....|::.:||
  Rat  1139 GI--------LLATGDDNGEIRIWN 1155

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rigNP_611499.3 WD40 <80..>215 CDD:295369 30/130 (23%)
WD40 80..>215 CDD:225201 30/130 (23%)
WD40 repeat 116..160 CDD:293791 10/45 (22%)
WD40 repeat 167..204 CDD:293791 11/36 (31%)
WD40 434..821 CDD:225201 70/455 (15%)
WD40 446..719 CDD:295369 51/331 (15%)
WD40 613..874 CDD:295369 42/239 (18%)
WD40 repeat 617..654 CDD:293791 9/36 (25%)
WD40 repeat 659..691 CDD:293791 3/53 (6%)
WD40 repeat 693..732 CDD:293791 9/45 (20%)
WD40 repeat 744..785 CDD:293791 8/43 (19%)
WD40 repeat 793..831 CDD:293791 6/27 (22%)
WD40 repeat 838..861 CDD:293791
Apaf1NP_076469.1 CARD_APAF1 7..92 CDD:260034
AAA_16 126..245 CDD:289934
NB-ARC 129..414 CDD:279299
WD40 <598..685 CDD:225201 2/6 (33%)
WD40 607..910 CDD:238121 77/465 (17%)
WD 1-1 613..652
WD40 repeat 623..655 CDD:293791
WD40 653..1038 CDD:225201 103/643 (16%)
WD 1-2 655..694 6/20 (30%)
WD40 repeat 661..697 CDD:293791 7/23 (30%)
WD 1-3 697..738 11/48 (23%)
WD40 repeat 702..740 CDD:293791 11/45 (24%)
WD 1-4 741..780 14/75 (19%)
WD40 repeat 747..789 CDD:293791 18/155 (12%)
WD 1-5 796..837 21/129 (16%)
WD40 repeat 801..837 CDD:293791 18/124 (15%)
WD 1-6 838..877 9/52 (17%)
WD40 repeat 843..882 CDD:293791 7/52 (13%)
WD 1-7 880..910 5/29 (17%)
WD40 repeat 885..909 CDD:293791 4/23 (17%)
Interpropeller linker. /evidence=ECO:0000250 910..921 2/10 (20%)
WD 2-1 922..958 4/36 (11%)
WD 2-2 959..998 12/44 (27%)
WD40 961..1235 CDD:238121 42/239 (18%)
WD40 961..>1235 CDD:225201 42/239 (18%)
WD40 repeat 964..1001 CDD:293791 10/37 (27%)
WD 2-3 1001..1040 6/38 (16%)
WD40 repeat 1006..1030 CDD:293791 1/23 (4%)
WD 2-4 1042..1080 8/56 (14%)
WD40 repeat 1048..1082 CDD:293791 9/49 (18%)
WD 2-5 1083..1122 7/38 (18%)
WD40 repeat 1089..1124 CDD:293791 7/34 (21%)
WD 2-6 1125..1164 8/39 (21%)
WD40 repeat 1130..1174 CDD:293791 7/34 (21%)
WD 2-7 1176..1213
WD40 repeat 1181..1203 CDD:293791
WD 2-8 1214..1249
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4155
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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