Protein Alignment rig and Wdsub1

DIOPT Version :10

• Sequence 1: NP_611499.3
• Gene: rig / 37335
• FlyBaseID: FBgn0250850
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: NP_001366327.1
• Gene: Wdsub1 / 72137
• MGIID: 1919387
• Length: 475
• Species: Mus musculus
• Alignment Length: 679
• Identity: 115/679 - (16%)
• Similarity: 200/679 - (29%)
• Gaps: 307/679 - (45%)

  Fly   570 VRAMAECPDDMNKIALG------CS-DRRVAFFDISKLTTSCLPIDSV-YVSSNVYCLAWSPNCL 626
            :..:|:..||::..|..      || |:.:..:.:|....  ||...: :.:..|:|..:||:..
Mouse     5 IHTLADHGDDVSCCAFSAALLATCSLDKTIRLYSLSDFAE--LPYSPLKFHTYAVHCCCFSPSGH 67

  Fly   627 ELAFGTFDGTVGILDVERMKVKTHLRTPHKKEVYSLVWQDHFIYFIVNRVLGFFDLRKSKIEPTI 691
            .||..:.|||                        :::|..|..:.:.       .|.:....|..
Mouse    68 VLASCSTDGT------------------------TVLWSSHSGHTLT-------VLEQPGGSPVR 101

  Fly   692 VNCISRPSYLSIRDSFLFVGTDDGLLQIHERDSGMEKSWSP---------FIRQSALFARYVTDI 747
            |.|.|..|      ::|..|..||.:.:          |:.         .::.|:|.|     .
Mouse   102 VCCFSPDS------AYLASGAADGSIAL----------WNAQTYKLYRCGSVKDSSLVA-----C 145

  Fly   748 AWCPLDSNKFAV--SGNDRSVYVMEFQPTERNWKTLHTFTANTEKA---SITSMRWSH------- 800
            |:.| |...|..  ||.|.:|:       :...:.||     :|||   .||...:|.
Mouse   146 AFSP-DGGLFVTGSSGGDLTVW-------DDRMRCLH-----SEKAHDLGITCCSFSSQPLSGGE 197

  Fly   801 -TQKHLLLTFHIEGKVCLWNCNAPEKPPLTITYHCPMWCGMFLPTNENIIMCSGKALSVELIDIK 864
             .|.:.|.:...:.::.||        .:|||                      :.|..|| ..|
Mouse   198 GLQSYQLASCGQDCEIKLW--------AVTIT----------------------RVLGFEL-KYK 231

  Fly   865 DALEGDEKSICPKVDALLNVKWASKSLTQPYAPVLTAAEKKRQRRDQRKAAAKLEVDVANKDQKK 929
            ..|.|.    |                    ||||..|
Mouse   232 STLSGH----C--------------------APVLACA--------------------------- 245

  Fly   930 IQESVTAVIDNPTNDKCTQETPVEEMLEALSLDKEQNNRSAKECPKCKEQSPDSFTHSRTCLYLT 994
                                                                  |:|....|
Mouse   246 ------------------------------------------------------FSHDGKML--- 253

  Fly   995 QKELNKSALEKLAIVLTEDSAKIDKSVLISKLFSSKVMAKELIATELTNLKHSNTKDIAPLCLAM 1059
                              .|..:||||:|..:....|     :.|...:.::..|...||..|.:
Mouse   254 ------------------ASGSVDKSVIIHGIGPQSV-----LHTLTQHTRYVTTCAFAPNTLLL 295

  Fly  1060 STFKLREELEQHIANKTLTERHVSLAPSVSFTLWQ----DCCRAYA-----KQMEEKGYIMHAAT 1115
            :|..:         :||:             .:||    ..|:|.:     |...|:......:.
Mouse   296 ATGSM---------DKTV-------------NIWQFDLETPCQAGSMNDPLKHFTEEWSEEDVSV 338

  Fly  1116 YLFSQGMQSEAIKLFLANEYYKEALVHARICLPATDPLIKTV-----INNWLEHLEGTGNFAAAA 1175
            :|.:||:: :.:.:|.||....:.|:|......|.|..|:::     :...:|.|....:..::.
Mouse   339 WLRAQGLE-DLVGIFRANNIDGKELLHLTKESLAGDLKIESLGLRSKVLRSIEELRAKMDSLSSG 402

  Fly  1176 L----ICVLDNEMLR-------GYSYLRK 1193
            :    ||.:..|:::       ||||.|:
Mouse   403 IPDEFICPITRELMKDPVIASDGYSYERE 431

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rig	NP_611499.3	WD40 repeat	116..160	CDD:293791
		WD40 repeat	167..204	CDD:293791
		WD40	446..719	CDD:475233	31/156 (20%)
		WD40	613..874	CDD:475233	54/282 (19%)
		WD40 repeat	617..654	CDD:293791	8/36 (22%)
		WD40 repeat	659..691	CDD:293791	4/31 (13%)
		WD40 repeat	693..732	CDD:293791	8/38 (21%)
		WD40 repeat	744..785	CDD:293791	10/42 (24%)
		WD40 repeat	793..831	CDD:293791	8/45 (18%)
		WD40 repeat	838..861	CDD:293791	2/22 (9%)
Wdsub1	NP_001366327.1	WD40	<3..310	CDD:441893	90/555 (16%)
		WD 1	10..47		8/38 (21%)
		WD40 repeat	16..52	CDD:293791	7/37 (19%)
		WD 2	52..91		11/69 (16%)
		WD40 repeat	57..93	CDD:293791	11/66 (17%)
		WD 3	95..134		10/54 (19%)
		WD40 repeat	101..136	CDD:293791	9/50 (18%)
		WD 4	137..176		13/56 (23%)
		WD40 repeat	143..177	CDD:293791	11/51 (22%)
		WD 5	178..227		12/78 (15%)
		WD40 repeat	183..235	CDD:293791	14/82 (17%)
		WD 6	236..275		17/169 (10%)
		WD40 repeat	241..264	CDD:293791	11/124 (9%)
		WD40 repeat	283..307	CDD:293791	7/45 (16%)
		SAM_WDSUB1	327..398	CDD:188904	14/71 (20%)
		U-box	403..475	CDD:398320	8/29 (28%)