DRSC/TRiP Functional Genomics Resources

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Protein Alignment rig and TEP1

DIOPT Version :10

Sequence 1:NP_611499.3 Gene:rig / 37335 FlyBaseID:FBgn0250850 Length:1235 Species:Drosophila melanogaster
Sequence 2:NP_009041.2 Gene:TEP1 / 7011 HGNCID:11726 Length:2627 Species:Homo sapiens


Alignment Length:1257 Identity:229/1257 - (18%)
Similarity:379/1257 - (30%) Gaps:488/1257 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 PDGGLLYAGIRCI----------------------------NYISAPP-ANGEQPQVVTMSTRIN 59
            |||.|..|..||.                            .:.|.|| |.|:.|..:..|    
Human  1492 PDGPLRTAAKRCYGKRPGLEDTAHILIAAQLWKTCDADASGTFRSCPPEALGDLPYHLLQS---- 1552

  Fly    60 ILALDVSPMWGLGNGGPTKPFAIVGDDLSVQVWDCALG---EAVIGH--------KAHQHQHEAR 113
                        ||.|....|.   .:|.|......||   ..:..|        |..|...|| 
Human  1553 ------------GNRGLLSKFL---TNLHVVAAHLELGLVSRLLEAHALYASSVPKEEQKLPEA- 1601

  Fly   114 DVRVVH---HTTNSVLMSYLANGNILSMDASDLVIYCVASNTYCRRSTFISPRNH-QLTM----- 169
            ||.|..   ....|:|..|   ..:|...|::..:    .:..|.:::.:|.|.| |.|:     
Human  1602 DVAVFRTFLRQQASILSQY---PRLLPQQAANQPL----DSPLCHQASLLSRRWHLQHTLRWLNK 1659

  Fly   170 ---------------VRCSP------YNDNLFAVGTAMGNVLVCDLRKMNIVYKFHGHKAPICGL 213
                           |..||      .|....|||||.|.|.:.|||                  
Human  1660 PRTMKNQQSSSLSLAVSSSPTAVAFSTNGQRAAVGTANGTVYLLDLR------------------ 1706

  Fly   214 AWREVPAAEDEKTNNLALSAEEWRSRNGGQEEKPKTKPPPLTKSKAAESDDPFDIYNFDHL---- 274
            .|                           ||||..........:....|||...:..||.|    
Human  1707 TW---------------------------QEEKSVVSGCDGISACLFLSDDTLFLTAFDGLLELW 1744

  Fly   275 EYEFGAPIAERRRKSSEDCGGEFVGLEKPAGAAVLDFVEACESVKAELLAS-------------R 326
            :.:.|..:.:.:....:..|                   .|.|....|||:             |
Human  1745 DLQHGCRVLQTKAHQYQITG-------------------CCLSPDCRLLATVCLGGCLKLWDTVR 1790

  Fly   327 QEDKTQHVEVTLHDCEPTKPTGPLSDASTISNKNDASDSTEGSLEVIQYSS-------------- 377
            .:...||......:|....|.|.:.          |:.|..||:...|...              
Human  1791 GQLAFQHTYPKSLNCVAFHPEGQVI----------ATGSWAGSISFFQVDGLKVTKDLGAPGASI 1845

  Fly   378 -----SSDDAVIVDG------------EAAKPKREVLHHIYHQAE--VHASGTPQTKSE------ 417
                 :....|:..|            |.|:......||.:..|.  :||.....|..|      
Human  1846 RTLAFNVPGGVVAVGRLDSMVELWAWREGARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQV 1910

  Fly   418 -------PQ---SNLQVVPAISAETISLTSVNSTHLETLLVSIDGDEV--------MMIWNTNTG 464
                   |:   .:|.:.||:|                :.:|.|||.|        :.|:..::|
Human  1911 WSGSLGRPRGHLGSLSLSPALS----------------VALSPDGDRVAVGYRADGIRIYKISSG 1959

  Fly   465 AHAGKNYSKSKTAGKLNNVYWLNNHVIVSLSRH-QLFFWSVE------------FERKMLRYKIS 516
            :...:..:.......|   .||:..|:||.:.. .|..|:::            |::.:|....|
Human  1960 SQGAQGQALDVAVSAL---AWLSPKVLVSGAEDGSLQGWALKECSLQSLWLLSRFQKPVLGLATS 2021

  Fly   517 KDKSHSCHLQDIVSFACDSSKEMIWLCRNNRQIGMMNPKTGRMADF-YGTVAFGVRAMAEC---P 577
                     |::::.|.:.....:|    .||: :..|.  :..|| .||...|......|   .
Human  2022 ---------QELLASASEDFTVQLW----PRQL-LTRPH--KAEDFPCGTELRGHEGPVSCCSFS 2070

  Fly   578 DDMNKIALGCSDRRVAFFDISKLTTSCLPIDSVYVSSNVYC-------LAWSPNCLELAFGTFDG 635
            .|...:|.|..||.:..:|:.      .|...|.:.|...|       .||:.:.|.::..: ||
Human  2071 TDGGSLATGGRDRSLLCWDVR------TPKTPVLIHSFPACHRDWVTGCAWTKDNLLISCSS-DG 2128

  Fly   636 TVGILDVER-MKVKTHLRTPHKKEVYSL-VWQDHFIYFIVNRVLGFFDLRKSKIEPT-------- 690
            :||:.|.|. .::...|  .|:..|.:: ..::|.:....:..|..:|  ...:|.|        
Human  2129 SVGLWDPESGQRLGQFL--GHQSAVSAVAAVEEHVVSVSRDGTLKVWD--HQGVELTSIPAHSGP 2189

  Fly   691 IVNCIS----------------------------------------------RPSYLSIRDSFLF 709
            |.:|.:                                              |.:.:|.....:.
Human  2190 ISHCAAAMEPRAAGQPGSELLVVTVGLDGATRLWHPLLVCQTHTLLGHSGPVRAAAVSETSGLML 2254

  Fly   710 VGTDDGLLQIHERDSGMEKSWSPFIRQSALFARYVTDIAWCPLDSNKFAVSGNDRSVYVMEFQPT 774
            ..::||.:::.:.....:.:..|  |.||.    ||.:||.|  ....|||||.....:: :|..
Human  2255 TASEDGSVRLWQVPKEADDTCIP--RSSAA----VTAVAWAP--DGSMAVSGNQAGELIL-WQEA 2310

  Fly   775 ER-------------NWKTLHTF--TANTEKAS-----------------------------ITS 795
            :.             .|.:.|||  .:..||.|                             :||
Human  2311 KAVATAQAPGHIGALIWSSAHTFFVLSADEKISEWQVKLRKGSAPGNLSLHLNRILQEDLGVLTS 2375

  Fly   796 MRWSHTQKHLLLTFHIEGK-VCLWNCNAPE-------KPPLTITYHCPMWCGMFLPTNENIIMC- 851
            :.|: ...|.|:....:.| :|:...:||.       :.|:.::.|......:..|.:..::.. 
Human  2376 LDWA-PDGHFLILAKADLKLLCMKPGDAPSEIWSSYTENPMILSTHKEYGIFVLQPKDPGVLSFL 2439

  Fly   852 ----SGK-------ALSVE-----LIDIKDALEGDEKS-ICPKVDALL-NV-------KWASKSL 891
                ||:       .:::|     ||.|..|....|.| :|...|.:| |:       :|.:.::
Human  2440 RQKESGEFEERLNFDINLENPSRTLISITQAKPESESSFLCASSDGILWNLAKCSPEGEWTTGNM 2504

  Fly   892 TQPYAPVLTAAEKKRQRRDQ---RKAAAKLEVDVA----------NKDQKKIQE-SVTAVIDNPT 942
            .|..|   ...|.:....|.   |::.|.::.|.:          .:.::||.. ||||:...| 
Human  2505 WQKKA---NTPETQTPGTDPSTCRESDASMDSDASMDSEPTPHLKTRQRRKIHSGSVTALHVLP- 2565

  Fly   943 NDKCTQETPVEEMLEALSLDKE 964
                       |:|...|.|::
Human  2566 -----------ELLVTASKDRD 2576

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rigNP_611499.3 WD40 repeat 116..160 CDD:293791 7/46 (15%)
WD40 repeat 167..204 CDD:293791 15/62 (24%)
WD40 446..719 CDD:475233 63/360 (18%)
WD40 613..874 CDD:475233 68/393 (17%)
WD40 repeat 617..654 CDD:293791 11/44 (25%)
WD40 repeat 659..691 CDD:293791 6/40 (15%)
WD40 repeat 693..732 CDD:293791 5/84 (6%)
WD40 repeat 744..785 CDD:293791 15/55 (27%)
WD40 repeat 793..831 CDD:293791 10/45 (22%)
WD40 repeat 838..861 CDD:293791 4/39 (10%)
TEP1NP_009041.2 TEP1 N-terminal 1 1..30
TEP1_N 1..29 CDD:428450
TEP1 N-terminal 2 31..60
TEP1_N 31..59 CDD:428450
TEP1 N-terminal 3 61..90
TEP1_N 61..89 CDD:428450
TEP1 N-terminal 4 91..120
TEP1_N 91..119 CDD:428450
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 193..214
TROVE 226..676 CDD:461724
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 383..402
DUF5920 687..889 CDD:466045
DUF4062 900..1008 CDD:463823
NACHT 1162..1337 CDD:428606
WD 1 1411..1448
WD 2 1674..1713 18/83 (22%)
WD40 <1680..1958 CDD:441893 62/367 (17%)
WD40 repeat 1680..1716 CDD:293791 16/80 (20%)
WD 3 1716..1754 7/37 (19%)
WD40 repeat 1722..1757 CDD:293791 7/34 (21%)
WD 4 1757..1796 7/57 (12%)
WD40 repeat 1762..1801 CDD:293791 9/57 (16%)
WD 5 1798..1837 8/48 (17%)
WD40 repeat 1804..1840 CDD:293791 8/45 (18%)
WD 6 1840..1879 4/38 (11%)
WD40 repeat 1845..1881 CDD:293791 4/35 (11%)
WD40 1849..2268 CDD:441893 79/464 (17%)
WD 7 1882..1921 8/38 (21%)
WD40 repeat 1888..1923 CDD:293791 6/34 (18%)
WD 8 1925..1964 11/54 (20%)
WD 9 1967..2005 8/40 (20%)
WD40 repeat 1972..2013 CDD:293791 9/43 (21%)
WD 10 2008..2047 9/54 (17%)
WD40 repeat 2016..2059 CDD:293791 12/58 (21%)
WD 11 2059..2098 9/44 (20%)
WD40 repeat 2064..2103 CDD:293791 10/44 (23%)
WD 12 2105..2143 10/38 (26%)
WD40 repeat 2111..2145 CDD:293791 9/34 (26%)
WD 13 2146..2183 7/38 (18%)
WD40 repeat 2151..2235 CDD:293791 8/85 (9%)
WD 14 2185..2233 2/47 (4%)
WD40 2231..>2391 CDD:475233 31/169 (18%)
WD 15 2236..2275 4/38 (11%)
WD40 repeat 2241..2280 CDD:293791 6/40 (15%)
WD 16 2278..2317 14/45 (31%)
WD40 repeat 2283..2307 CDD:293791 10/26 (38%)
WD 17 2319..2355 7/35 (20%)
WD40 repeat 2326..2359 CDD:293791 7/32 (22%)
WD 18 2368..2417 10/49 (20%)
WD40 repeat 2372..2418 CDD:293791 10/46 (22%)
WD 19 2459..2500 10/40 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2506..2551 7/47 (15%)
WD 20 2553..2590 10/36 (28%)
WD 21 2592..2626
Blue background indicates that the domain is not in the aligned region.

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