DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rig and Gemin5

DIOPT Version :9

Sequence 1:	NP_611499.3	Gene:	rig / 37335	FlyBaseID:	FBgn0250850	Length:	1235	Species:	Drosophila melanogaster
Sequence 2:	XP_006246458.1	Gene:	Gemin5 / 691231	RGDID:	1586275	Length:	1498	Species:	Rattus norvegicus

Alignment Length:	1280	Identity:	267/1280 - (20%)
Similarity:	448/1280 - (35%)	Gaps:	392/1280 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 CINYISAPPANGEQPQVVTMSTRINILALDVSPMWGLGNGGPTKPFAIVG--------------- 84
            |.....|.|..     :...:.|.::..:.|.|..|...|.|  ||.:||
  Rat    16 CARCSDAAPGG-----IFGFAARTSVFLVRVGPGAGASPGAP--PFRVVGELVGHTERVSGFTFS 73

  Fly    85 -------------DDLSVQVWDCALGEAVIGHKAHQHQHEARDVRVVHHTTNSVLMSYLANGNIL 136
                         ||.:|::||......|..|..||            ||.:::..|......|:
  Rat    74 HHPGQYNLCATSSDDGTVKIWDVETKAVVTEHALHQ------------HTISALHWSPTVKDLIV 126

  Fly   137 SMDASDLVIYCVASNTYCRRSTFISPRNHQLTMVRCSPYNDNLFAVGTAMGNVLVCDL-RKMNIV 200
            |.|... |::|...|....:..|..||  .:..:.|||:::||.|:|...|.|::.|: :|..:|
  Rat   127 SGDEKG-VVFCYWLNRSDSQHLFTEPR--AIFCLTCSPHHENLVAIGYKDGIVIIIDISKKGEVV 188

  Fly   201 YKFHGHKAPICGLAWREVPAAEDEKTNNLALSAEEWRSRNGGQEEKPKTKPPPLTKSKAAESDDP 265
            ::..||...|..:||             ..||.|:..|.|  |||               .|::|
  Rat   189 HRLRGHDDEIHSIAW-------------CPLSGEDCLSIN--QEE---------------NSEEP 223

  Fly   266 FDIYNFDHLEYEFGAPIAERRRKSSEDCGGEFVGLEKPAGAAVLDFVEACESVKAELLASRQEDK 330
             ||.|        |..|||                        ....:.|      .||:..:|:
  Rat   224 -DIPN--------GKLIAE------------------------TPITKGC------YLATGSKDQ 249

  Fly   331 TQHVEVTLHDCEPTKPTGPLSDASTISNKNDASDSTEGSLEVIQYSSSSDDAVIVDGEAAKPKRE 395
            |    :.:..|...:....|                  .|..::..|...|..:         :|
  Rat   250 T----IRIWSCSRGRGVMVL------------------KLPFLKRRSGGVDPTV---------KE 283

  Fly   396 VLHHIYHQAEVHASGTPQTKSEPQSNLQVVPAISAETISLTSVNSTHLETLLVSIDGDEVMMIWN 460
            .|....|          ..|::|..                         |:.|..|.| :::|:
  Rat   284 RLWLTLH----------WPKNQPTQ-------------------------LVSSCFGGE-LLLWD 312

  Fly   461 TNTGAHAGKNYSKSKTAGKLNNVYWLNNHVIVSLSRHQLFFWSVEFERKMLRYKISKDKSHSCHL 525
            ......  :.|:...|:.:.:|    ::.::.:|...:      ..:.|.|....|.|:...|
  Rat   313 LTQSWR--RKYTLFSTSAEGHN----HSRIVFNLCPLK------TEDGKQLLLSTSMDRDVKC-- 363

  Fly   526 QDIVSFACDSSKEMIWLCRNNRQIGMMNPKTGRMADFYGTVAFGVRAMAECPDDMNKIALGCSDR 590
            .|:.:..|      .|..          |..|..|          .::|..|.|:..:|:|..|.
  Rat   364 WDMATLEC------CWTL----------PSLGGFA----------YSLAFSPVDVGSLAIGVGDG 402

  Fly   591 RVAFFDISKLTTSCLPIDSVY--------VSSNVYCLAWSPN---CLELAFGTFDGTVGILDVER 644
            .:..:       :.|.|.:.|        |.|.|..|.|.||   |  |||||.||.||:.|...
  Rat   403 MIRVW-------NTLSIKNNYDVKNFWQGVKSKVTALCWHPNKEGC--LAFGTDDGKVGLYDTCS 458

  Fly   645 MKVKTHLRTPHKKEVYSLVW-----------------------------QDHFIYFIVNRVLGFF 680
            .|......|.|||.||.|.|                             ..|..:.:....   |
  Rat   459 NKPPQISSTYHKKTVYRLAWGPPVPPMSLGGEGDRPSLTLYSCGGEGIVLQHNPWKLSGEA---F 520

  Fly   681 DLRKSKIEPTIVNCISRPSYLSIR----DSFLFVGTDDGLLQIHERDSGMEKSWSPFIRQSALFA 741
            |:.|...:...:. ...|.:..|.    ...:.:|.:||.::|.:         .|.::......
  Rat   521 DINKLMRDTNSIR-YKLPVHTEISWKGDGKVMALGNEDGSIEIFQ---------VPNLKLLCTIQ 575

  Fly   742 RY---VTDIAW------CPLDSNKFAVSGNDRSVY------VMEFQP------TERNWKTL--HT 783
            ::   |..|.|      .|..|...|...|:..:|      |:|..|      || .::||  ||
  Rat   576 QHHKLVNAIVWHHEHGSRPELSCLLASGSNNAVIYVHNLKAVLESNPESPITITE-PYRTLSGHT 639

  Fly   784 FTANTEKASITSMRWSHTQKHLLLTFHIEGKVCLWNCNAPEKPPLTITYH-----CPMWCGMFLP 843
                   |.:||:.||......|::...:|...:|:. ..|:|......|     |..|.    |
  Rat   640 -------AKVTSLAWSPHHDGRLVSACYDGTAQVWDA-LREEPLFNFRGHRGRLLCVAWS----P 692

  Fly   844 TNENIIMCSGKALSVE--LIDIKDALEGDEKSICPKVDALLNVKWASKSLTQPYAPVLTAAEKKR 906
            .:...|........|.  |..::|.....:...|        ::...|.|:| :.|.|     |:
  Rat   693 VDPECIYSGADDFCVYRWLTSMQDHSRPPQGKKC--------IELEKKRLSQ-FKPKL-----KK 743

  Fly   907 QRRDQRKAAAKLEVDVANKDQKKIQESVTAVIDNPTNDKCTQETPVEEML-------------EA 958
            :::...:...|.:..:.|:|: .::|:: |.::|..:|:..:|...|..|             .|
  Rat   744 KKKPTLRLPIKQDSSIGNEDE-SVRENL-APVENGLSDQDGEEEAQEPELPPSPVVCGEPVSCTA 806

  Fly   959 LSLDKEQNNRSA--------KECPKCKEQSPDSFTHSRTCLYL-------TQKELNKSALEKLAI 1008
            :||..|::..:.        ||.||.|.::......:|:.|.|       :::||::..| .||.
  Rat   807 VSLGLEKSKVTVTSKVASLKKEPPKEKPEALLKKRKARSMLPLSTSLDHRSKEELHRDCL-VLAT 870

  Fly  1009 V------LTED-SAKIDKSVLISKLFSSKVMAKELIATE-LTNLKHSNTKDIAPLCLAMSTFKLR 1065
            .      |.|| ||.:::...:. ||:.:.....::.|| ..:|:..:.:....|.|...  .|:
  Rat   871 ATHARAELHEDVSADLEERFHLG-LFTDRAALYRMMETEGKGHLESGHPELFHQLMLWKG--DLK 932

  Fly  1066 EELEQHIANKTLTERHVSLAPSVSFTLWQDCCRAYAKQMEEKGYIMHAATYLFSQGMQSEAIKLF 1130
            ..|:.......||:..|::||...:::|.....|:|||:..:...:.||:||.|.....||::|.
  Rat   933 GVLQAAAERGELTDSLVAVAPVAGYSVWLWAVEAFAKQLCFQDQYVKAASYLLSIHRVYEAVELL 997

  Fly  1131 LANEYYKEALVHARICLPATDPLIKTVINNWLEHLEGTGNFAAAA 1175
            .:|..|:||:..|:..|...||::|.:..:|...||..|::|.||
  Rat   998 RSNHLYREAIAVAKARLRPEDPVLKDLYLSWGSILERDGHYAIAA 1042

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rig	NP_611499.3	WD40	<80..>215	CDD:295369	39/163 (24%)
		WD40	80..>215	CDD:225201	39/163 (24%)
		WD40 repeat	116..160	CDD:293791	9/43 (21%)
		WD40 repeat	167..204	CDD:293791	12/37 (32%)
		WD40	434..821	CDD:225201	92/453 (20%)
		WD40	446..719	CDD:295369	65/316 (21%)
		WD40	613..874	CDD:295369	72/326 (22%)
		WD40 repeat	617..654	CDD:293791	16/39 (41%)
		WD40 repeat	659..691	CDD:293791	8/60 (13%)
		WD40 repeat	693..732	CDD:293791	6/42 (14%)
		WD40 repeat	744..785	CDD:293791	17/60 (28%)
		WD40 repeat	793..831	CDD:293791	9/37 (24%)
		WD40 repeat	838..861	CDD:293791	3/24 (13%)
Gemin5	XP_006246458.1	WD40	<53..411	CDD:225201	100/555 (18%)
		WD40	57..408	CDD:295369	98/548 (18%)
		WD40 repeat	68..107	CDD:293791	7/38 (18%)
		WD40 repeat	112..149	CDD:293791	7/37 (19%)
		WD40 repeat	154..193	CDD:293791	12/38 (32%)
		WD40 repeat	199..269	CDD:293791	27/160 (17%)
		WD40	287..710	CDD:225201	103/533 (19%)
		WD40 repeat	287..329	CDD:293791	10/79 (13%)
		WD40	329..668	CDD:295369	84/406 (21%)
		WD40 repeat	336..374	CDD:293791	8/51 (16%)
		WD40 repeat	382..422	CDD:293791	10/56 (18%)
		WD40 repeat	429..454	CDD:293791	15/26 (58%)
		WD40 repeat	474..538	CDD:293791	7/67 (10%)
		WD40 repeat	542..575	CDD:293791	6/41 (15%)
		WD40 repeat	582..619	CDD:293791	8/36 (22%)
		WD40	631..>710	CDD:295369	20/90 (22%)
		WD40 repeat	642..679	CDD:293791	9/37 (24%)
		WD40 repeat	685..710	CDD:293791	5/28 (18%)
		BAR	<1338..1445	CDD:299863
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	127	1.000	Inparanoid score	I4590
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D283127at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_106770
Panther	1	1.100	-	-	LDO	PTHR46362
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.970