DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rig and Dcaf10

DIOPT Version :9

Sequence 1:	NP_611499.3	Gene:	rig / 37335	FlyBaseID:	FBgn0250850	Length:	1235	Species:	Drosophila melanogaster
Sequence 2:	NP_694807.2	Gene:	Dcaf10 / 242418	MGIID:	2140179	Length:	566	Species:	Mus musculus

Alignment Length:	692	Identity:	117/692 - (16%)
Similarity:	194/692 - (28%)	Gaps:	329/692 - (47%)

- Green bases have known domain annotations that are detailed below.

  Fly   241 GGQEEKPKTKPPPLTKSKAAESDDPFDIYNFDHLEYEFGAPIAERR------RKSSEDCGGEFVG 299
            ||.|.....:||||                        |.|.|..|      |.:|...|.:...
Mouse    10 GGDETAGAEEPPPL------------------------GGPAAASRPPSPAPRPASPQRGADAAS 50

  Fly   300 LEKPAGAAVLDFVEACESVKAELLASRQEDKTQHVEVTLHDCEPTKPTGPLSDASTISNKNDASD 364
            ....||:                                    |..|.||     .:|....|.:
Mouse    51 PPPVAGS------------------------------------PRLPGGP-----AVSPAERAGE 74

  Fly   365 -STEGSLEVIQYSSSSDDAVIVDGEAAKPKREVLHHIYHQAEVHASGTPQTKSEPQSNLQVVPAI 428
             :..|:||:...::|:.                      ||::..|.:|:.:|.|.
Mouse    75 FAAPGALELSAATASAS----------------------QAKLSPSSSPRRRSRPD--------- 108

  Fly   429 SAETISLTSVNSTHLETLLVSIDGDEVMMIW----NTNTGAHAGK--------NYSKSKTAGK-- 479
                                          |    .:..|..||.        .:.:.::.|:
Mouse   109 ------------------------------WRAGGRSRQGLGAGLGGPGARLFGWLRERSLGRGL 143

  Fly   480 -----------LNNVYWL---NNHVIVSLSRHQLFFWSVEFERKMLRYKISKDKSHSCHLQDIVS 530
                       :.|:|..   .:.|.:|...|...| ::|:         |.|.|       :::
Mouse   144 FVDPARDNFRTMTNLYGSIHPADSVYLSTRTHGAVF-NLEY---------SPDGS-------VLT 191

  Fly   531 FACDSSKEMIWLCRNNRQIGMMNPKTGRMADFYGTVAFGVRAMAECPDDM----NKIALGCS-DR 590
            .||:.::.:::...:::.|..::                 .|..:|.:::    |::...|| |.
Mouse   192 VACEQTEVLLFDPISSKHIKTLS-----------------EAHEDCVNNIRFLDNRLFATCSDDT 239

  Fly   591 RVAFFDISKLTTSCLPIDSVYVSSNVYCLAWSPNCLELAFGTFDGTVGILDVERMKVKTHLRTPH 655
            .:|.:|:.||.|....:..  .:|.|..:.:..|...|....|||.|.|.|..|.   |....||
Mouse   240 TIALWDLRKLNTKVCTLHG--HTSWVKNIEYDTNTRLLVTSGFDGNVIIWDTNRC---TEDGCPH 299

  Fly   656 KKEVYSLVWQDHFIYFIVNRVLGFFDLR---KSKIEPTIVNCISRPSYLSIRDSFLFVGTDDG-L 716
            ||                     ||..|   :.::.|   :|           |.:.:.|..| |
Mouse   300 KK---------------------FFHTRFLMRMRLTP---DC-----------SKMLISTSSGYL 329

  Fly   717 LQIHERD--SGMEKSWSPFIRQSALFARYVTD--------------IAWCPL---DSNKF----- 757
            |.:||.|  ..:|....|.:|     ||..|.              ::..|.   |||..
Mouse   330 LILHELDLTKSLEVGSYPILR-----ARRTTSSSDLTTTSSSSGSRVSGSPCHHNDSNSTEKHMS 389

  Fly   758 -------------------AVSG-NDRSVYVMEFQPTERNWKTLHTFTANTEKASITSMRWSHTQ 802
                               .|.| .||...:...|...:.|.||...::||:...
Mouse   390 RASQREGVSPRNSLEVLTPEVPGERDRGNCITSLQLHPKGWATLLRCSSNTDDQE---------- 444

  Fly   803 KHLLLTFHIEGKVCLWNC------NAPEKP-----PLTITYH 833
                           |.|      .||.:|     .|.:|::
Mouse   445 ---------------WTCVYEFQEGAPVRPVSPRCSLRLTHY 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rig	NP_611499.3	WD40	<80..>215	CDD:295369
		WD40	80..>215	CDD:225201
		WD40 repeat	116..160	CDD:293791
		WD40 repeat	167..204	CDD:293791
		WD40	434..821	CDD:225201	80/473 (17%)
		WD40	446..719	CDD:295369	55/309 (18%)
		WD40	613..874	CDD:295369	56/280 (20%)
		WD40 repeat	617..654	CDD:293791	10/36 (28%)
		WD40 repeat	659..691	CDD:293791	4/34 (12%)
		WD40 repeat	693..732	CDD:293791	10/41 (24%)
		WD40 repeat	744..785	CDD:293791	13/82 (16%)
		WD40 repeat	793..831	CDD:293791	6/48 (13%)
		WD40 repeat	838..861	CDD:293791
Dcaf10	NP_694807.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..72		21/126 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	87..123		10/96 (10%)
		WD40	<171..326	CDD:295369	44/228 (19%)
		WD 1	173..212		9/55 (16%)
		WD40	<178..>326	CDD:225201	42/221 (19%)
		WD40 repeat	179..214	CDD:293791	8/51 (16%)
		WD 2	216..254		11/37 (30%)
		WD40 repeat	221..257	CDD:293791	9/35 (26%)
		WD 3	258..297		12/43 (28%)
		WD40 repeat	263..289	CDD:293791	8/25 (32%)
		WD 4	303..342		12/52 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	354..413		6/58 (10%)
		WD 5	415..455		10/64 (16%)
		WD 6	477..515
		WD40	524..562	CDD:197651
		WD 7	533..566
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4155
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900