DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rig and WDR7

DIOPT Version :9

Sequence 1:	NP_611499.3	Gene:	rig / 37335	FlyBaseID:	FBgn0250850	Length:	1235	Species:	Drosophila melanogaster
Sequence 2:	NP_001369416.1	Gene:	WDR7 / 23335	HGNCID:	13490	Length:	1490	Species:	Homo sapiens

Alignment Length:	1435	Identity:	246/1435 - (17%)
Similarity:	433/1435 - (30%)	Gaps:	510/1435 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LLYAGIRCINYISAPPANGEQPQVVTMSTRINILALDVSP-------------------MWGLGN 73
            ||:.....|..:|...|:.::..:|:.|....:...|||.                   .:.:||
Human    59 LLFGHTASITCLSKACASSDKQYIVSASESGEMCLWDVSDGRCIEFTKLACTHTGIQFYQFSVGN 123

  Fly    74 GGPTK-------PFAIVGDDLSVQV-----------WDCALGEAVIGHKAHQHQHEARDVRVVHH 120
            ....:       |..:|.|..|::|           |..::  ::|  ::|:.|.:.    ||..
Human   124 QREGRLLCHGHYPEILVVDATSLEVLYSLVSKISPDWISSM--SII--RSHRTQEDT----VVAL 180

  Fly   121 TTNSVLMSYLANGNILSMDASDLV-------IYCVASNTYCRRSTFISPRNHQLTMVRCSPYNDN 178
            :...:|..::....|..|..::.:       |||    ..|:..:|.:.....|.:| ||.|
Human   181 SVTGILKVWIVTSEISDMQDTEPIFEEESKPIYC----QNCQSISFCAFTQRSLLVV-CSKY--- 237

  Fly   179 LFAVGTAMGNVLVCDLRKMNIVYKFHGHKAPICGLAWREVPAAEDEKTNNLALSAEE---WRSRN 240
             :.|..|....|:|.....|             |..|          |....:|:::   |  ..
Human   238 -WRVFDAGDYSLLCSGPSEN-------------GQTW----------TGGDFVSSDKVIIW--TE 276

  Fly   241 GGQEEKPKTKPPPLTKSKAAESDDPFDIYNF----DHLEYEFGAPIAERRRKSSEDCGGEFVGLE 301
            .||....|.....|..|.:..||....:.|.    .|:       :.:|:.|....|
Human   277 NGQSYIYKLPASCLPASDSFRSDVGKAVENLIPPVQHI-------LLDRKDKELLIC-------- 326

  Fly   302 KPAGAAVLDFVEACESVKAELLASRQEDKTQHVEV-----------------------------T 337
                ..|..|...|.....:||.  |.|.:..:.:                             .
Human   327 ----PPVTRFFYGCREYFHKLLI--QGDSSGRLNIWNISDTADKQGSEEGLAMTTSISLQEAFDK 385

  Fly   338 LHDCEPTKPTGPLSDASTISNKNDASDST----------------EGSLEVIQYSSSSDDAVI-- 384
            |:.|    |.|.:...|.|.|.|:....|                :||:.::   .::..|::
Human   386 LNPC----PAGIIDQLSVIPNSNEPLKVTASVYIPAHGRLVCGREDGSIVIV---PATQTAIVQL 443

  Fly   385 VDGE-----AAKPKREVLHH-------IY-HQAE------------------------------- 405
            :.||     ...|.|.:..|       :| ||..
Human   444 LQGEHMLRRGWPPHRTLRGHRNKVTCLLYPHQVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIF 508

  Fly   406 -VHASGTPQTKSEPQ---SNLQ--VVPAISAETISLTSVN--------STHL-----------ET 445
             ||.....|....|:   :.:|  :....|..::.|.|:.        |.||           :.
Human   509 CVHGGEITQLLVPPENCSARVQHCICSVASDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDD 573

  Fly   446 LLVSIDGDEVMMIWNTNTGAHAGKNYSKSKTAGKLNNVYWLN------NHVIVSLSRHQLFFWSV 504
            .||....|..:.:|..:|||       ..:....:..|..||      ...:.|||..     :|
Human   574 YLVVGCSDGSVYVWQMDTGA-------LDRCVMGITAVEILNACDEAVPAAVDSLSHP-----AV 626

  Fly   505 EFERKMLRYKISKDKSHSCH-LQDIVS--FACDSSKEMIWLCRNNRQIGMMNPKTGRMADFYGTV 566
            ..::.|.|..::..|:.:.| ||.:.:  .|.::|.:           |.: ||       |...
Human   627 NLKQAMTRRSLAALKNMAHHKLQTLATNLLASEASDK-----------GNL-PK-------YSHN 672

  Fly   567 AFGVRAMAECPDDMNKIALGCSDRRVAFFDISKLTTSCLPIDSVYVSSNVYCLAWSPNCLELAFG 631
            :..|:|:        |..|...|..|.|||:..|....|..:    :|.......||..|:.|.|
Human   673 SLMVQAI--------KTNLTDPDIHVLFFDVEALIIQLLTEE----ASRPNTALISPENLQKASG 725

  Fly   632 TFDGTVGILDVER-----MKVKTHLRTPHKKEVYSLVWQDHFIYFIVNRVLGFFDLRKSKIEPTI 691
            :.|.....|..:|     .:||..::...|:.:.....:|..|          ...|:.:.:|..
Human   726 SSDKGGSFLTGKRAAVLFQQVKETIKENIKEHLLDDEEEDEEI----------MRQRREESDPEY 780

  Fly   692 VNCISRP----SY-LSIRDSFLFV------GTDD----------GLLQIHERDS-------GMEK 728
            .:..|:|    .| |::..:.||:      |.::          |:|:.|...|       |...
Human   781 RSSKSKPLTLLEYNLTMDTAKLFMSCLHAWGLNEVLDEVCLDRLGMLKPHCTVSFGLLSRGGHMS 845

  Fly   729 SWSPFIRQSALFARYVTDIAWCPLDSNKFAV-------SGNDRSVYVMEFQPTERNWKTLHTFTA 786
            ...|...|.|           |.|...|..|       .|..:..|.:....|.::..::.:. |
Human   846 LMLPGYNQPA-----------CKLSHGKTEVGRKLPASEGVGKGTYGVSRAVTTQHLLSIISL-A 898

  Fly   787 NTEKASITSMRW--SHTQKHLLLTFHIEGKVCLWNCNAPEKPPLTITYHCPMWCGMFLPTNENII 849
            || ..|:|:..:  .|.:|                  .|.:||...|.......|. .||:.||:
Human   899 NT-LMSMTNATFIGDHMKK------------------GPTRPPRPSTPDLSKARGS-PPTSSNIV 943

  Fly   850 MCSGKALSVELIDIK-DA------------------------------------LEGDEKSICPK 877
            ....|.::..::..: ||                                    |.|.:|...|.
Human   944 QGQIKQVAAPVVSARSDADHSGSDPPSAPALHTCFLVNEGWSQLAAMHCVMLPDLLGLDKFRPPL 1008

  Fly   878 VDALLNVKWASKSL-TQPYAPVLTAAEKKRQRRDQRKAAAKLEVDV------------------- 922
            ::.|.. :|..:.| .:..|..|..||.:|..:..||.|    :|.
Human  1009 LEMLAR-RWQDRCLEVREAAQALLLAELRRIEQAGRKEA----IDAWAPYLPQYIDHVISPGVTS 1068

  Fly   923 -----------ANKDQKKIQESVTAVIDNPTNDKCTQETPVEEMLEALSLDKEQNNRSAKEC--- 973
                       |:..:.|:||....::|:.....|....|   .::.:|...|:..:.|...
Human  1069 EAAQTITTAPDASGPEAKVQEEEHDLVDDDITTGCLSSVP---QMKKISTSYEERRKQATAIVLL 1130

  Fly   974 -------------------PKCKEQSPDSF-------THS---RTCLYLT-------------QK 996
                               |:...|.|:.|       .:|   .||..||             ..
Human  1131 GVIGAEFGAEIEPPKLLTRPRSSSQIPEGFGLTSGGSNYSLARHTCKALTFLLLQPPSPKLPPHS 1195

  Fly   997 ELNKSALEKLAIVLTEDSAKIDKSVLISKLFSSKVMAKELIATELTNLKHSNTKDIAPLCLAMST 1061
            .:.::|::.:....|.....:|.|.::..|......|::.:|.....|..|...|.|
Human  1196 TIRRTAIDLIGRGFTVWEPYMDVSAVLMGLLELCADAEKQLANITMGLPLSPAADSA-------- 1252

  Fly  1062 FKLREELEQHIANKTLTERHVSLAPSVSFTLWQDCCRAYAKQMEEKGYIMHAATYLFSQGMQSEA 1126
                 ...:|..:...|.|..:...:::..:.:....|...|.::.   ||..|...::|.....
Human  1253 -----RSARHALSLIATARPPAFITTIAKEVHRHTALAANTQSQQN---MHTTTLARAKGEILRV 1309

  Fly  1127 IKLFL 1131
            |::.:
Human  1310 IEILI 1314

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rig	NP_611499.3	WD40	<80..>215	CDD:295369	29/152 (19%)
		WD40	80..>215	CDD:225201	29/152 (19%)
		WD40 repeat	116..160	CDD:293791	9/50 (18%)
		WD40 repeat	167..204	CDD:293791	10/36 (28%)
		WD40	434..821	CDD:225201	87/456 (19%)
		WD40	446..719	CDD:295369	62/307 (20%)
		WD40	613..874	CDD:295369	60/339 (18%)
		WD40 repeat	617..654	CDD:293791	10/41 (24%)
		WD40 repeat	659..691	CDD:293791	4/31 (13%)
		WD40 repeat	693..732	CDD:293791	12/66 (18%)
		WD40 repeat	744..785	CDD:293791	7/47 (15%)
		WD40 repeat	793..831	CDD:293791	6/39 (15%)
		WD40 repeat	838..861	CDD:293791	6/22 (27%)
WDR7	NP_001369416.1	WD 1	17..56
		WD40	<19..102	CDD:421866	10/42 (24%)
		WD40 repeat	22..62	CDD:293791	2/2 (100%)
		WD 2	62..104		8/41 (20%)
		WD40 repeat	68..109	CDD:293791	7/40 (18%)
		WD40 repeat	114..153	CDD:293791	7/38 (18%)
		WD 3	156..199		8/50 (16%)
		WD40 repeat	162..208	CDD:293791	8/53 (15%)
		WD 4	324..366		8/55 (15%)
		WD 5	404..443		5/41 (12%)
		WD40	408..>598	CDD:421866	30/199 (15%)
		WD40 repeat	409..461	CDD:293791	8/54 (15%)
		WD 6	462..507		4/44 (9%)
		WD40 repeat	516..558	CDD:293791	6/41 (15%)
		WD 7	558..597		9/45 (20%)
		WD40 repeat	563..589	CDD:293791	4/25 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	761..783		4/31 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	911..945		11/52 (21%)
		WD 8	1351..1390
		WD40	<1357..1426	CDD:421866
		WD40 repeat	1357..1391	CDD:293791
		WD 9	1392..1432
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4155
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900