DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rig and Apaf1

DIOPT Version :9

Sequence 1:	NP_611499.3	Gene:	rig / 37335	FlyBaseID:	FBgn0250850	Length:	1235	Species:	Drosophila melanogaster
Sequence 2:	NP_001036023.1	Gene:	Apaf1 / 11783	MGIID:	1306796	Length:	1249	Species:	Mus musculus

Alignment Length:	640	Identity:	116/640 - (18%)
Similarity:	220/640 - (34%)	Gaps:	182/640 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   273 HLEYEFGAPIAERRRKSSEDCGGEFVGLEKPAGAAVLDFVEACESVKAELLASRQEDKTQHVEVT 337
            ||.:||   :|.|.....:||             ||.:..:...|:...||..:.....    |.
Mouse   521 HLIHEF---VAYRHILDEKDC-------------AVCENFQEFLSLNGHLLGRQPFPNI----VQ 565

  Fly   338 LHDCEPTKPTGPLSDASTISNKNDASDSTEGS-----LEVIQYSSSSDDAVIVDGEAAKPKREVL 397
            |..|||        :.|.:..:.......||.     ||.|...:..:.:.:|    .:|..:.:
Mouse   566 LGLCEP--------ETSEVYRQAKLQAKQEGDTGRLYLEWINKKTIKNLSRLV----VRPHTDAV 618

  Fly   398 HHIYHQAE---VHASGTPQTKSEPQSNLQVVPAISAETISLTSVNSTHLETL----------LVS 449
            :|.....:   :.:.|..:|       |||..|.:.|  .|..:.:...|.|          :.:
Mouse   619 YHACFSQDGQRIASCGADKT-------LQVFKAETGE--KLLDIKAHEDEVLCCAFSSDDSYIAT 674

  Fly   450 IDGDEVMMIWNTNTG--AHAGKNYSKSKTAGKLNNVYWLN--NHVIVSLSRHQLFFWSVEFERKM 510
            ...|:.:.||::.||  .|....:|:     ::|..::.|  ||::::...:..|....:..:|.
Mouse   675 CSADKKVKIWDSATGKLVHTYDEHSE-----QVNCCHFTNKSNHLLLATGSNDFFLKLWDLNQKE 734

  Fly   511 LR---YKISKDKSHSCHL--QDIVSFACDSSKEM-IWLCRNNRQIGMMNPKTGRMADFYGTVAFG 569
            .|   :..:...:| |..  .|.:..:|.:...: :|..|:..:...:|.|.     |:
Mouse   735 CRNTMFGHTNSVNH-CRFSPDDELLASCSADGTLRLWDVRSANERKSINVKR-----FF------ 787

  Fly   570 VRAMAECPDDMNKIALGCS------------DRRVAFFDISKLTTSCL-PIDSVYVSSNVYC--- 618
             .:..:.|:|:..|...||            ..:|..|||.  |:..| .|.:.:.|:..||
Mouse   788 -LSSEDPPEDVEVIVKCCSWSADGDKIIVAAKNKVLLFDIH--TSGLLAEIHTGHHSTIQYCDFS 849

  Fly   619 -------LAWSPNCLELAFGTFDGTVGILDVERMKVKTHLRTPH--------------------- 655
                   :|.|..|:||  ...|..:.:.|     .:.||...|
Mouse   850 PYDHLAVIALSQYCVEL--WNIDSRLKVAD-----CRGHLSWVHGVMFSPDGSSFLTASDDQTIR 907

  Fly   656 ---------------KKEVYSLVWQDHFIYFIVNRVLGFFDLRKSK------IEPTIVNCISRPS 699
                           |:|:..:..::..:...|:.:.| ..|...|      :....|:|.....
Mouse   908 VWETKKVCKNSAIVLKQEIDVVFQENETMVLAVDNIRG-LQLIAGKTGQIDYLPEAQVSCCCLSP 971

  Fly   700 YLSIRDSFLFVGTDDGLLQIHERDSGMEKSWSPFIRQSALFARYVTDIAWCPLDSNKFAVSGNDR 764
            :|    .::..|.:||.::|.|..:....|.....:::....::..|        .|..:|.::.
Mouse   972 HL----EYVAFGDEDGAIKIIELPNNRVFSSGVGHKKAVRHIQFTAD--------GKTLISSSED 1024

  Fly   765 SVYVMEFQPTERNWKTLHTFTANTEKASITSMRWSHTQKHLLLTFHIEGKVCLWN 819
            ||..:      .||:|.........:.::...|.  .|...||::..:|.|.:||
Mouse  1025 SVIQV------WNWQTGDYVFLQAHQETVKDFRL--LQDSRLLSWSFDGTVKVWN 1071

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rig	NP_611499.3	WD40	<80..>215	CDD:295369
		WD40	80..>215	CDD:225201
		WD40 repeat	116..160	CDD:293791
		WD40 repeat	167..204	CDD:293791
		WD40	434..821	CDD:225201	82/471 (17%)
		WD40	446..719	CDD:295369	61/357 (17%)
		WD40	613..874	CDD:295369	44/259 (17%)
		WD40 repeat	617..654	CDD:293791	11/46 (24%)
		WD40 repeat	659..691	CDD:293791	4/37 (11%)
		WD40 repeat	693..732	CDD:293791	8/38 (21%)
		WD40 repeat	744..785	CDD:293791	8/40 (20%)
		WD40 repeat	793..831	CDD:293791	8/27 (30%)
		WD40 repeat	838..861	CDD:293791
Apaf1	NP_001036023.1	CARD_APAF1	7..92	CDD:260034
		NB-ARC	129..374	CDD:395745
		APAF1_C	453..587	CDD:407760	19/93 (20%)
		WD40	607..910	CDD:238121	61/342 (18%)
		WD 1-1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:21827944	613..652		10/47 (21%)
		WD40 repeat	623..655	CDD:293791	8/40 (20%)
		WD 1-2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:21827944	655..694		7/38 (18%)
		WD40 repeat	661..697	CDD:293791	7/35 (20%)
		WD 1-3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:21827944	697..738		8/45 (18%)
		WD40 repeat	702..740	CDD:293791	7/37 (19%)
		WD 1-4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:21827944	741..780		6/39 (15%)
		WD40 repeat	747..789	CDD:293791	9/54 (17%)
		WD 1-5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:21827944	796..837		11/42 (26%)
		WD40 repeat	801..837	CDD:293791	9/37 (24%)
		WD 1-6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:21827944	838..877		9/40 (23%)
		WD40 repeat	843..882	CDD:293791	9/45 (20%)
		WD 1-7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:21827944	880..910		3/29 (10%)
		WD40 repeat	885..909	CDD:293791	1/23 (4%)
		Interpropeller linker	910..921		0/10 (0%)
		WD 2-1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:21827944	922..958		6/36 (17%)
		WD 2-2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:21827944	959..998		8/42 (19%)
		WD40	961..1235	CDD:238121	25/131 (19%)
		WD40 repeat	964..999	CDD:293791	9/38 (24%)
		WD 2-3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:21827944	1001..1040		8/52 (15%)
		WD40 repeat	1006..1030	CDD:293791	5/37 (14%)
		WD 2-4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:21827944	1042..1080		8/32 (25%)
		WD40 repeat	1048..1082	CDD:293791	8/26 (31%)
		WD 2-5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:21827944	1083..1122
		WD40 repeat	1089..1124	CDD:293791
		WD 2-6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:21827944	1125..1164
		WD40 repeat	1130..1174	CDD:293791
		WD 2-7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:21827944	1176..1213
		WD40 repeat	1181..1203	CDD:293791
		WD 2-8. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:21827944	1214..1249
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4155
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900