DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rig and Wdr7

DIOPT Version :9

Sequence 1:	NP_611499.3	Gene:	rig / 37335	FlyBaseID:	FBgn0250850	Length:	1235	Species:	Drosophila melanogaster
Sequence 2:	NP_001014981.1	Gene:	Wdr7 / 104082	MGIID:	1860197	Length:	1489	Species:	Mus musculus

Alignment Length:	668	Identity:	121/668 - (18%)
Similarity:	214/668 - (32%)	Gaps:	232/668 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   566 VAFGVRAMAEC------PDDMNKIALGCSDRRVAFFDISK-------------------LTTSCL 605
            |.:|.:|...|      .||...|..||.|.::..:|:|.                   |:.:|.
Mouse    11 VLWGRKAPTHCISSILLTDDGGTIVTGCHDGQICLWDVSVELEVNPRALLFGHTASITCLSKACA 75

  Fly   606 PIDSVY---VSSNVYCLAWSPN---CLE----------LAFGTFDGTVG---------------- 638
            ..|..|   .|:|.....|..|   |:|          :.|..|  :||
Mouse    76 SGDKRYTVSASANGEMCLWDVNDGRCIEFTKLACTHTGIQFYQF--SVGNQQEGRLLCHGHYPEI 138

  Fly   639 -ILDVERMKVKTHLRTPHKKEVYSLVWQDHFIYFIVNRVLGFFDLRKSKIEPTIVNCISRPSYLS 702
             ::|...::|           :||||                     |||.|..::.:|......
Mouse   139 LVVDATSLEV-----------LYSLV---------------------SKISPDWISSMSIIRSQR 171

  Fly   703 IRDSFLFVGTDDGLLQ---IHERDSGMEKSWSPFIRQS-ALFARYVTDIAWCPLDSNKFAVSGND 763
            .::..:...:..|:|:   :....|||:.:...|..:| .::.:....|::|..         ..
Mouse   172 TQEDTVVALSVTGILKVWIVTSEMSGMQDTEPIFEEESKPIYCQNCQSISFCAF---------TQ 227

  Fly   764 RSVYVMEFQPTERNWKTLHT--FTANTEKASITSMRWSHTQKHLLLTFHIEGKVCLWNCNAPEKP 826
            ||:.|:    ..:.|:....  ::......|.....|:...      |....||.:|..|..
Mouse   228 RSLLVV----CSKYWRVFDAGDYSLLCSGPSENGQTWTGGD------FVSADKVIIWTENGQ--- 279

  Fly   827 PLTITYHCPMWCGMFLPTNENIIMCSGKA-------LSVELIDIKDALEGDEKSICPKVDALLN- 883
              :..|..|..|   ||.:::.....|||       :...|:|.||    .|..|||.|.....
Mouse   280 --SYIYKLPASC---LPASDSFRSDVGKAVENLIPPVQHSLLDQKD----KELVICPPVTRFFYG 335

  Fly   884 -VKWASKSLTQPYAP-------VLTAAEKKRQRRDQ----------RKAAAKLE------VD--- 921
             .::..|.|.|..:.       :...|||  |..|:          ::|..||:      :|
Mouse   336 CKEYLHKLLIQGDSSGRLNIWNIADIAEK--QEADEGLKMTTCISLQEAFDKLKPCPAGIIDQLS 398

  Fly   922 -VANKDQKKIQESVTAVIDNPTNDK--CTQE-----------TPVEEMLEALSLDKE--QNNRSA 970
             :.|.::..   .|||.:..|.:.:  |.:|           |.:.::|:...:.:.  ..:|:.
Mouse   399 VIPNSNEPL---KVTASVYIPAHGRLVCGREDGSIIIVPATQTAIVQLLQGEHMLRRGWPPHRTL 460

  Fly   971 KECPKCKEQSPDSFTHSRTCLYLTQKELNKSALEKLAIVLTEDSAKIDKSVLISKLFSSKVMAKE 1035
            :           ...:..|||....                :.||:.|:..|||......|:..:
Mouse   461 R-----------GHRNKVTCLLYPH----------------QVSARYDQRYLISGGVDFSVIIWD 498

  Fly  1036 LIATELTNLKHSNTKDIAPLCLAMSTFKLREELEQHIANKTLTERHVSLAPSVSFTLWQDCCRAY 1100
            :.:.|:.::...:..:|..|.:.......|   .||......::..|.|.
Mouse   499 IFSGEMKHIFCVHGGEITQLLVPPENCSAR---VQHCICSVASDHSVGLL--------------- 545

  Fly  1101 AKQMEEKGYIMHAATYLF 1118
              .:.||..||.|:.:||
Mouse   546 --SLREKKCIMLASRHLF 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rig	NP_611499.3	WD40	<80..>215	CDD:295369
		WD40	80..>215	CDD:225201
		WD40 repeat	116..160	CDD:293791
		WD40 repeat	167..204	CDD:293791
		WD40	434..821	CDD:225201	56/318 (18%)
		WD40	446..719	CDD:295369	39/213 (18%)
		WD40	613..874	CDD:295369	54/303 (18%)
		WD40 repeat	617..654	CDD:293791	10/66 (15%)
		WD40 repeat	659..691	CDD:293791	8/31 (26%)
		WD40 repeat	693..732	CDD:293791	6/41 (15%)
		WD40 repeat	744..785	CDD:293791	6/42 (14%)
		WD40 repeat	793..831	CDD:293791	6/37 (16%)
		WD40 repeat	838..861	CDD:293791	6/29 (21%)
Wdr7	NP_001014981.1	WD40	16..274	CDD:295369	53/310 (17%)
		WD 1	17..56		10/38 (26%)
		WD40	<19..199	CDD:225201	38/213 (18%)
		WD40 repeat	22..62	CDD:293791	8/39 (21%)
		WD 2	62..104		9/41 (22%)
		WD40 repeat	68..109	CDD:293791	10/40 (25%)
		WD40 repeat	114..153	CDD:293791	8/51 (16%)
		WD 3	156..199		7/42 (17%)
		WD40 repeat	162..205	CDD:293791	6/42 (14%)
		WD 4	324..366		10/43 (23%)
		WD40	341..>592	CDD:225201	47/273 (17%)
		WD 5	404..443		7/41 (17%)
		WD40	408..>592	CDD:295369	34/201 (17%)
		WD 6	462..507		11/60 (18%)
		WD40 repeat	516..558	CDD:293791	11/61 (18%)
		WD 7	558..597		2/4 (50%)
		WD40 repeat	563..589	CDD:293791
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	754..783
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	911..947
		WD 8	1350..1389
		WD40 repeat	1355..1391	CDD:293791
		WD40	<1356..1425	CDD:295369
		WD40	<1364..>1426	CDD:225201
		WD 9	1391..1431
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4155
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900