DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13436 and Cfap206

DIOPT Version :9

Sequence 1:	NP_611498.1	Gene:	CG13436 / 37334	FlyBaseID:	FBgn0034532	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_001333991.1	Gene:	Cfap206 / 69329	MGIID:	1916579	Length:	622	Species:	Mus musculus

Alignment Length:	596	Identity:	137/596 - (22%)
Similarity:	252/596 - (42%)	Gaps:	102/596 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 VIYMVHLLARDRRKG------LLKYDLNKPTACAIEGFVNTIVDSYVNSKDCTMANMKMAWVMKK 88
            |.:||..:..|...|      |:|.|:.|        .|...|...:::|:.::..:||.
Mouse    33 VAFMVKAVVLDPSNGFNMDRTLIKTDVQK--------LVKLCVARLLDNKNPSLDTIKMQ----- 84

  Fly    89 GVTIDLEYVKK-----KYEEKFQTELQLLIKDILQYPETCSKVQLDQLFAKMQVFIVACYSLGSP 148
             |..|:.|..:     ::....::.|.::.::|.. ....::.:|:.|:.|:..:::....||||
Mouse    85 -VYFDMNYTSREDFLEEHHRVLESRLGIVSREITD-NRASAREELENLYRKIVSYVLLRSGLGSP 147

  Fly   149 KNHVLLKLTAQALNSVIGRSDLQNYVLKKKYHRLEYLQRLSATVGGIVIYNND-GPDGDRENVRS 212
            .:..:::....||.||..:::|..::...|..:...|:.|:..|.||.::|.| |..|:.
Mouse   148 TDIKIVREATAALQSVFPQAELATFLTLSKKDKERQLKELTMIVTGIRLFNRDCGKGGEG----- 207

  Fly   213 VVDDLEMAQKNTEAAFAASMGRAVKMQSTCQAALDDLINIDHKDETLTYRVPLEHLDRLNQFAAT 277
             :|||           .|.:..|:   .|....:|..:.| .:|:...|...||.:.. |...|.
Mouse   208 -IDDL-----------PAILHEAI---PTTTQHIDSQLQI-AQDQAFRYTAILEKVTN-NPLMAK 255

  Fly   278 Y---FMLHRCLTTLNEH--YQKTVYL--------IEVEHKRYQCVICKIDDTLSMRTAIDSELIF 329
            .   :||...|..:.::  :.:||..        :|:..|:....:.::...:..:||:.:..:|
Mouse   256 ELQPYMLKEALYNVRQYEIFLQTVLSDIITCAEEVEMMIKQLAAQLEQLKMAVKSKTAVPTSQVF 320

  Fly   330 PHFVYLSQVWGNLNNYLNHIVELNKLREQVEA-LVVDDLMTLTKATIAELQALHKRIKKPKVCSF 393
            |.||.|:.:|.:..:....|..|:.|...:|. |...:|:...|..:..|..:   :.|..:...
Mouse   321 PIFVALASLWMSFQDETVLISVLSNLTTNLELFLGTHELLFPEKVMLGLLDGV---VVKSDLTRI 382

  Fly   394 EERMDAVKEL-----------QTDGNFCKLNKADIKEFCSLAMTITNGLLMPAQVTRKLCSNVD- 446
            ||.|:...||           :|..||.|| ....:.||.....:|:|||:|......:....:
Mouse   383 EEHMEERVELADFRTQEWLFPETTANFNKL-LIQYRGFCGYTFAVTDGLLLPGNPAIGILKYKEK 446

  Fly   447 -ITFGFRDPRYARFAELRFEPFIAAFRKVVFNNANLALLFKLDDALIEQELQNLV---------- 500
             .||..||..|. ||| ..:.:|...::....||.|..|.:|     .|:.:.|:
Mouse   447 YYTFSTRDAAYT-FAE-NPDHYIHLIKEKAKKNAELIQLLEL-----HQQFETLIPYSQMRDVDK 504

  Fly   501 --VEPPKQTDFECQTEMVVTNDLTPANWINVTWNAWDYHRETIHLANIRKKQTNDAQTNISYGRR 563
              ::|..:.|...||:   |:.|.|.......||.|:..|:.|.|||:|:|.|:..||::|:.||
Mouse   505 HYIKPITKCDNGTQTD---THILPPTTMRTYEWNEWELRRKAIKLANLRQKITHSVQTDLSHMRR 566

  Fly   564 NAQNQTYNCRQ 574
            :..:|.|..::
Mouse   567 DNTSQVYPLKE 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13436	NP_611498.1	DUF3508	219..491	CDD:288841	66/298 (22%)
Cfap206	NP_001333991.1	FAP206	217..490	CDD:371849	66/288 (23%)
Cfap206	NP_001333991.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	568..593		2/10 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836443
Domainoid	1	1.000	50	1.000	Domainoid score	I11674
eggNOG	1	0.900	-	-		E1_2CN2C
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	108	1.000	Inparanoid score	I4902
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56434
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008200
OrthoInspector	1	1.000	-	-		oto94471
orthoMCL	1	0.900	-	-		OOG6_104627
Panther	1	1.100	-	-	LDO	PTHR21442
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4911
SonicParanoid	1	1.000	-	-		X6167
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.790