DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13436 and Cfap206

DIOPT Version :9

Sequence 1:	NP_611498.1	Gene:	CG13436 / 37334	FlyBaseID:	FBgn0034532	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	NP_001073169.1	Gene:	Cfap206 / 366347	RGDID:	1310641	Length:	622	Species:	Rattus norvegicus

Alignment Length:	598	Identity:	135/598 - (22%)
Similarity:	256/598 - (42%)	Gaps:	106/598 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 VIYMVHLLARDRRKG------LLKYDLNKPTACAIEGFVNTIVDSYVNSKDCTMANMKMAWVMKK 88
            |.:||..:..|...|      |:|.|:.|        .|...|...:::|:.::..:||.
  Rat    33 VAFMVKAVVLDPSNGFNMDRTLVKTDVQK--------LVKLCVARLLDNKNPSLDTIKMQ----- 84

  Fly    89 GVTIDLEYVKK-----KYEEKFQTELQLLIKDILQYPETCSKVQLDQLFAKMQVFIVACYSLGSP 148
             |..|:.|..:     ::....::.|.::.::|.. ...|:|.:|:.|:.|:..:::....||||
  Rat    85 -VYFDMNYTSREDFLEEHHRVLESRLGIVSREITD-TRACAKEELENLYRKIVSYVLLRSGLGSP 147

  Fly   149 KNHVLLKLTAQALNSVIGRSDLQNYVLKKKYHRLEYLQRLSATVGGIVIYNND-GPDGDRENVRS 212
            .:..:::....||.||..:::|..::...|..:...|:.|:..|.||.::|.| |..|:.
  Rat   148 TDIKIVREATAALQSVFPQAELCTFLTLSKKDKERQLKELTMIVTGIRLFNRDCGKGGEG----- 207

  Fly   213 VVDDLEMAQKNTEAAFAASMGRAVKMQSTCQAA--LDDLINIDHKDETLTYRVPLEHLDRLNQFA 275
             :|||.                |:.:::.....  :|..:.| .:::...|...:|.:.. |...
  Rat   208 -IDDLP----------------AILLEAIPATTHHIDSQLQI-AQEQAFRYTAIIEKVTN-NPLM 253

  Fly   276 ATY---FMLHRCLTTLNEH--YQKTVYL--------IEVEHKRYQCVICKIDDTLSMRTAIDSEL 327
            |..   :||...|..:.::  :.:||..        :|:..|:....:.::..|:..:||:.:..
  Rat   254 AKELQPYMLKEALYNVRQYEIFLQTVLSDIITCAEEVELMTKQLAAQLEQLKMTVKSKTAVPTSQ 318

  Fly   328 IFPHFVYLSQVWGNLNNYLNHIVELNKLREQVEA-LVVDDLMTLTKATIAELQALHKRIKKPKVC 391
            :||.|:.|:.:|.:..:....|..|:.|...:|. |...||:...|.....|..:   |.|..:.
  Rat   319 VFPIFIALASLWTSFQDETVLISVLSNLTTNLELFLGTHDLLFPEKVMQGLLDGV---IVKTDMT 380

  Fly   392 SFEERMDAVKEL-----------QTDGNFCKLNKADIKEFCSLAMTITNGLLMPAQVTRKLCSNV 445
            ..||.::...:|           :|..||.|| ....:.||.....:|:|||:|...|..:....
  Rat   381 RIEEHLEEKVQLADFRVLEWLFPETTANFNKL-LIQYRGFCGYTFAVTDGLLLPGNPTIGILKYK 444

  Fly   446 D--ITFGFRDPRYARFAELRFEPFIAAFRKVVFNNANLALLFKLDDALIEQELQNLV-------- 500
            :  .||..||..|: ||| ..:.:|...::....||.|..|.:|     .|:.:.|:
  Rat   445 EKYYTFNSRDAAYS-FAE-NPDHYINLIKEKAKKNAELIQLLEL-----HQQFETLIPYSQMKDV 502

  Fly   501 ----VEPPKQTDFECQTEMVVTNDLTPANWINVTWNAWDYHRETIHLANIRKKQTNDAQTNISYG 561
                ::|..:.:...||:   |:.|.|....:..||.|:..|:.|.|||:|:|.|:..||::|:.
  Rat   503 DKHFIKPITKCENGTQTD---THILPPTIVRSYEWNEWELRRKAIQLANLRQKMTHSVQTDLSHM 564

  Fly   562 RRNAQNQTYNCRQ 574
            ||:..:|.|..::
  Rat   565 RRDNASQVYPLKE 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13436	NP_611498.1	DUF3508	219..491	CDD:288841	63/300 (21%)
Cfap206	NP_001073169.1	DUF3508	217..490	CDD:288841	63/285 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340117
Domainoid	1	1.000	48	1.000	Domainoid score	I11645
eggNOG	1	0.900	-	-		E1_2CN2C
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	110	1.000	Inparanoid score	I4789
OMA	1	1.010	-	-		QHG56434
OrthoDB	1	1.010	-	-		D178619at33208
OrthoFinder	1	1.000	-	-		FOG0008200
OrthoInspector	1	1.000	-	-		oto97986
orthoMCL	1	0.900	-	-		OOG6_104627
Panther	1	1.100	-	-	LDO	PTHR21442
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6167
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.770