Protein Alignment FAM21 and washc2c

DIOPT Version :10

• Sequence 1: NP_611496.1
• Gene: FAM21 / 37331
• FlyBaseID: FBgn0034529
• Length: 1469
• Species: Drosophila melanogaster
• Sequence 2: XP_021328369.1
• Gene: washc2c / 567272
• ZFINID: ZDB-GENE-060825-87
• Length: 1381
• Species: Danio rerio
• Alignment Length: 1641
• Identity: 392/1641 - (23%)
• Similarity: 595/1641 - (36%)
• Gaps: 476/1641 - (29%)

  Fly     7 VDQIIAQAPDWTFAGDCALLALMKRISQNLEERGERTSRNLRDFETSVKQVDIALNNATTSLRSL 71
            ::::...:.:|:.|.|..|...::..||.:..:.....:.|.......|..|..|:........|
Zfish    26 LEEMQKSSTNWSLAADSGLFLFLRDFSQRMLSKTHEIEKQLDGLIRDTKATDSQLHTVFNDFLML 90

  Fly    72 QFGNQFVEYRV--EEVDD------ADLAMPEEKKKKPELPLKSSEELAK--EFLENNLRMFRKNY 126
            . ..||:|.||  |||:|      .....||::|.:.:   |.:|.:.|  |.:...|::....:
Zfish    91 S-NTQFIENRVYDEEVEDPTPKSETTERQPEQEKTREQ---KEAELIPKVQEAVNYGLKVLESAF 151

  Fly   127 EPVTIEVPDSDDEDGPVHSTT--VFRAKNPYDAIPLPYIIGTKEWQEHKYAGLYDSKENSEDDRS 189
            |.:.|:..:||.||..|....  :..||:.|...||||:||::.:.:....||.|.   |.|:.|
Zfish   152 EQLDIKAGNSDSEDEEVLEKVEPILEAKDLYVDRPLPYLIGSQAFMDQDDVGLGDL---SSDEMS 213

  Fly   190 EEFSSSSSDEKEPETKKIATPANKLEEQHLSDSSSLASFAREPAIVSPVINPAVQVAEPVIRTQP 254
            ......|..|.:.|.....|..:...:|   |.....:|.::|:|.|  .|.|
Zfish   214 IGSDRDSVLESDVEDGDEHTDQDDYSDQ---DEEVQGNFKKKPSIAS--YNDA------------ 261

  Fly   255 RPIINSQRNPHERDMFAALRQSPPSDDPPSTSSSPTSSPAF--------RNPSSRLPIVSTASLS 311
                 .:.| .:.|:|....:....||    ....|..|:|        :..:...|....:|||
Zfish   262 -----DEEN-DDSDIFGGSDKDEDEDD----LRKDTGVPSFADELAARIKGETQNKPEADRSSLS 316

  Fly   312 SSSSSPAQQPPRLFDEAVSTQTPKEAEIKPSQTKRMPVNLFNEDEFKSFMSEIVDKVQSKTPSSS 376
            |..|:.:                     |.|:||::|.....:|:.:.|
Zfish   317 SGPSTTS---------------------KKSKTKKVPKPQVEDDQDEMF---------------- 344

  Fly   377 VSPATTISTKEPPKTKKPVEEYPKPGPPKQIVEQTVPKRVNLFDDSPP---LSPTPRSEPVFNNT 438
                      .||..:.  |||...|....:..    ....||||...   .|..|::.||  ..
Zfish   345 ----------RPPTMED--EEYSPFGGKGGLFS----GGKGLFDDDDEGDLFSEAPKNVPV--EK 391

  Fly   439 KATGAIP-------KRSPVVVANNDEDNSLFGSS--PAMPKENPSKKPPKP---VTKSLFDDDLE 491
            :.|.|.|       |:.|....:....|||.||:  ...||.:.|:.|..|   :...|||||.:
Zfish   392 EKTVAQPTVEPHKTKKIPTGAVSIFPGNSLLGSANDSESPKSSDSRSPALPKASIGGGLFDDDED 456

  Fly   492 DDDFLSSFT-PKAKPPEQKLLSKPKPSLFDDDDLDIDDIFTKPSAQPKKLSERVAGKTSLFEDDD 555
            ||||.|..| .|:.|.:.|...|....||.:.|                           .||:|
Zfish   457 DDDFFSGKTQSKSTPGQDKKTPKKTVDLFGEAD---------------------------EEDED 494

  Fly   556 QDDVTDLFGSKKAKVIPKETSSGVSPNKNVETPVASKKSLFDDIEDEDLFGTPKAKNLIRSEPDN 620
            :||.|.:|..|....:|::   .:|.|...||....||.....:   .:|| |..||::.
Zfish   495 EDDDTAMFSGKAISALPQQ---DISANGEEETRPPEKKPPAGAV---SMFG-PGTKNILE----- 547

  Fly   621 DPEAVGEDKKQSEIAEQKSKNIETGEKQHQVIAENASVPILRDSPPPMEVTEQKSDDKEWEAVKD 685
                 |..|::...:|:.:|:.|:|.....|    .|.|.| .|...|:.....|||::.:..
Zfish   548 -----GLKKRRPSTSEESTKSEESGHAPEPV----KSSPAL-GSAEKMQSKSLFSDDEDSQIF-- 600

  Fly   686 DTSAANITKSK------------DLFSEDLTDDELFSST------SNNMAEPKSANETNEFNKPI 732
              |:.|.:|||            .:| :|..:::|||||      ......||:|..::.|:...
Zfish   601 --SSENTSKSKPTTQNKPSKAPLSIF-DDEEEEDLFSSTPKPVPVKKTSLPPKNALSSSLFSDDE 662

  Fly   733 EKYTS--QTEEN--VSP------VNPPTKL-SIKPT--DLFNEDFSDDDTFLSASMSK------- 777
            :::.|  .::||  |.|      ::.|::| |:|.|  |...:|..|:|.|.:.:.|.
Zfish   663 DQWMSSKSSKENPEVKPSGMKPSISAPSRLPSVKTTHKDGLFDDKDDEDLFAATNQSSKTSSQRV 727

  Fly   778 -----------NEPLVGTENEDIKKPSE-----VQLVKEIKAEELPQQLPENKIYEITAVVEKD- 825
                       .|||.|.:...||.|.|     |..:.|...|:....:.:.||.|     ||.
Zfish   728 SLLFEDEDDEDKEPLFGFKTPAIKTPPESKTSGVSSLFESTEEDTGPSVVKEKITE-----EKKK 787

  Fly   826 --ELVP------EMLSKP------------------QIDEP--VSETPPPDDYQSNVDPIISMVA 862
              |.||      |:..||                  .|.:|  ..|..|.|:.|....|.:....
Zfish   788 PVESVPSSEDSFEVKKKPAGAVSLFGGIDILGDKQDTIKKPPKTQEEIPDDELQKEGPPPMESKG 852

  Fly   863 DVTNKTSVDTLTPRKPADLAAAQQIMQNYSNLFSDEPPDDSEFFQT--LGSSGLSSLSASKIFDN 925
            ..|.||::                      :||.::..||.:.|.|  :..:..:|.|..|....
Zfish   853 TKTKKTAL----------------------SLFDEDDDDDDDDFSTDEIIPAPTASRSTEKNALK 895

  Fly   926 EHDFFEPALPNIPSATKPSPVTPGDQPSVSSDYGAMCLFSDVPPEDNDHAGEEVQ------KEAE 984
            ||.      |.:.|.            .|..|  ...|||.....|||   .:|.      |.|.
Zfish   896 EHG------PRMKST------------GVFQD--EELLFSQTQQRDND---PDVDLFATSPKPAV 937

  Fly   985 PQKDELASTTRIHTIFYDDFSETARAGAVQPAPKRFPFDDEPPPADETDRSEVKETPELQKPTSP 1049
            |.:....|..  .|:|.||..:...:.|...||.:.|.....|..:|.|:|....:.|   ||:|
Zfish   938 PPQSSAKSVA--PTLFGDDDDDDLFSSAKPKAPPKVPEKPSKPKTNEIDKSISTSSKE---PTNP 997

  Fly  1050 VKKLKMPNIN-------INVHALLPGS-----GSV---PKLIRKQESSSSERDEPQATVQTEAEA 1099
            :|..|...|.       :|...||||:     |:|   |.|        :....| |..:|..:.
Zfish   998 LKSKKTSRIGELQAVLALNPAGLLPGAVPRAPGAVSVIPGL--------AHTGLP-AAARTMPDH 1053

  Fly  1100 PSSGQNTVS----SADGVLQHVNKSRARGPAKRRPSTRRGRKENYAKSLLDAGQNEGPTASTRDS 1160
            ..|.:..||    :....|.:.||.||:|..||||.||..|.       |.|.|::..:......
Zfish  1054 QGSSEGGVSFDSPALISTLLNANKGRAKGAGKRRPQTRAARH-------LAAQQSDEASGENVSV 1111

  Fly  1161 PEVEHSERSSIKAPSPQYVKPEKL---FSTPAQQIQP-QLQRPPPSNTGGSFLDSPDE----DDS 1217
            .:.|.:..:|:...:|..|:|..|   .|.||....| :..||.      .||:..|:    ||.
Zfish  1112 QKNEPAMAASLPPFNPVSVRPSALTIPVSAPAPAKSPDEAVRPK------RFLEPTDDLFDSDDL 1170

  Fly  1218 FFNSVPTKTVEGKQGTDPPKSYRSFLDSPDADDKLFSDLENNKAGINVVPVEKKPPKMANSFLAS 1282
            |             .|.|..|.:..:.:.:...|..|:.|      :|.|.:|   ..|.|...|
Zfish  1171 F-------------ATKPVSSSKHKIQTTEEGQKKVSNTE------DVTPSKK---DQAPSIFDS 1213

  Fly  1283 PDEDDFLFDSVKTNATTTAQKAFAAEIMNAFQKVTTAPPKPSNAKEAAKPKSQAAPKLFDDSDDD 1347
            .|||  ||.:||                          ||       :..|::..|.|.:..:|.
Zfish  1214 HDED--LFATVK--------------------------PK-------SVQKAKHMPFLDEGGEDS 1243

  Fly  1348 DDDLFARAPSIQTASK--------------------PVQAKQPPKPAA--TSLFSSD-DEEAEVP 1389
            |:|:|....|....||                    |.:|::.||.|:  .|||..| |..|::.
Zfish  1244 DEDIFGAGKSKSLESKNSKKEASAVKSDIFQDEVKEPPKAQKNPKEASLDASLFDDDVDIFADLT 1308

  Fly  1390 VKSAPAKKLPVK--PSKSLFSDDDDDDDLFGGSSTSKAAAAKKTKPAARTASKPPASKTTTP--- 1449
            ..|.|.:|...|  .:||:|  |||.||:|...:         |||..:.:||   ||.:.|
Zfish  1309 GTSKPKEKKAKKKVETKSIF--DDDMDDIFSTGT---------TKPTVKPSSK---SKKSQPIQE 1359

  Fly  1450 ---TATIPSNSGDNPL 1462
               ||....|..|:||
Zfish  1360 PASTAETAHNIFDDPL 1375

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FAM21	NP_611496.1	PHA03307	353..>583	CDD:223039	59/245 (24%)
		PHA03307	931..>1207	CDD:223039	77/304 (25%)
		CAP-ZIP_m	1045..1163	CDD:464595	37/136 (27%)
washc2c	XP_021328369.1	CAP-ZIP_m	996..1131	CDD:464595	38/150 (25%)