DRSC/TRiP Functional Genomics Resources

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Protein Alignment FAM21 and WASHC2A

DIOPT Version :10

Sequence 1:NP_611496.1 Gene:FAM21 / 37331 FlyBaseID:FBgn0034529 Length:1469 Species:Drosophila melanogaster
Sequence 2:NP_001005751.1 Gene:WASHC2A / 387680 HGNCID:23416 Length:1341 Species:Homo sapiens


Alignment Length:1607 Identity:364/1607 - (22%)
Similarity:566/1607 - (35%) Gaps:447/1607 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 VDQIIAQAPDWTFAGDCALLALMKRISQNLEERGERTSRNLRDFETSVKQVDIALNNATTSLRSL 71
            |::|...:..|:.|.|..||..::..||....|.....:.:.......|..|..|:|.......|
Human    25 VEEIRRSSQSWSLAADAGLLQFLQEFSQQTISRTHEIKKQVDGLIRETKATDCRLHNVFNDFLML 89

  Fly    72 QFGNQFVEYRV--EEVDDADLAMPEEKKKKPELPLKSSEEL---AKEFLENNLRMFRKNYEPVTI 131
            . ..||:|.||  |||::..|....||.::.:...:...:|   .:|.:...|::....:|.:.|
Human    90 S-NTQFIENRVYDEEVEEPVLKAEAEKTEQEKTREQKEVDLIPKVQEAVNYGLQVLDSAFEQLDI 153

  Fly   132 EVPDSDDEDGPVHSTT--VFRAKNPYDAIPLPYIIGTKEWQEHKYAGL----------------- 177
            :..:||.|:...:...  :...|:.|...||||:||:|.:.|.:..||                 
Human   154 KAGNSDSEEDDANGRVELILEPKDLYIDRPLPYLIGSKLFMEQEDVGLGELSSEEGSVGSDRGSI 218

  Fly   178 YDSKENSEDDRS-EEFSSSSSDEKEPETKKIATPANKLEEQHLSDSSSLASFAREPAIVSPVINP 241
            .|::|..|::.| |:|:..|.:|:...|.:::      :|:...|..                  
Human   219 VDTEEEKEEEESDEDFAHHSDNEQNRHTTQMS------DEEEDDDGC------------------ 259

  Fly   242 AVQVAEPVIRTQPRPIINSQRNPHERDMFAALRQSPPSDDPPSTSSSPTSSPAFRNPSSRLPIVS 306
                                      |:||...:.....:....::.|..|              
Human   260 --------------------------DLFADSEKEEEDIEDIEENTRPKRS-------------- 284

  Fly   307 TASLSSSSSSPAQQPPRLFDEAVSTQTPKEAEIKPSQTKRMPVNLFNEDEFKSFMSEIVDKVQSK 371
                         :|....||..       |.||.....|                  ||:..:.
Human   285 -------------RPTSFADELA-------ARIKGDAVGR------------------VDEEPTT 311

  Fly   372 TPSSSVSPATTISTKEPPKTKKPVEEYPKPGPPKQIVEQTVPKRVNLFDDSPPLSPTPRSEPVFN 436
            .||....|..|:..|:..:|....||.....|||            |.|:.  .||......:|:
Human   312 LPSGEAKPRKTLKEKKERRTPSDDEEDNLFAPPK------------LTDED--FSPFGSGGGLFS 362

  Fly   437 NTKATGAIPKRSPVVVANNDEDNSLFGSSP-------AMPKENPSKKPPKPVTKSLFDDDLEDDD 494
            ..|.          :..:.||::.||..:|       ::.:|:.|.||.|.:........|.|.|
Human   363 GGKG----------LFDDEDEESDLFTEAPQDRQAGASVKEESSSSKPGKKIPAGAVSVFLGDTD 417

  Fly   495 -FLSSFTPKAKPPEQKLLSKPKPS--------LFDDDD-LDIDDIFTKPSAQPKKLSERVAGKTS 549
             |.::..|..|.|::.....|:.|        |||||| .|.||.|:.|.::|.|     .||..
Human   418 VFGAASVPSMKEPQKPEQPTPRKSPYGPPPTGLFDDDDGDDDDDFFSAPHSKPSK-----TGKVQ 477

  Fly   550 LFEDDDQDDVTDLFGSKKAKVIPKETSS-------------GVSPNKNVE--TPVASKKSLFDDI 599
            ...|...|:..||| .:||...|:.|.|             .:|.:||::  :...::|.||.|.
Human   478 STADIFGDEEGDLF-KEKAVASPEATVSQTDENKARAEKKVTLSSSKNLKPSSETKTQKGLFSDE 541

  Fly   600 ED-EDLFGTPKAKNLIRSE--PDNDPEAVG----EDKKQSEIAEQKSKNIETGEKQHQVIAENAS 657
            || ||||.:..|..|..:.  |...|..|.    ||::.:......:|.        |.:...|.
Human   542 EDSEDLFSSQSASKLKGASLLPGKLPTLVSLFDDEDEEDNLFGGTAAKK--------QTLCLQAQ 598

  Fly   658 VPILRDSPPPMEVTEQKSDDKEWEAVKDDTSAANITKSKD---LFSEDLTDDELFSSTSNNMAEP 719
                         .|:|:            .|:.::|.|.   |||.|..|.....::..::   
Human   599 -------------REEKA------------KASELSKKKASALLFSSDEEDQWNIPASQTHL--- 635

  Fly   720 KSANETNEFNKPIEKYTSQTEENVSPVNPPTKLSIKPTDLFNEDFSDDDTFLSASMSKNEPLVGT 784
              |:::....:|.:..|.|::|         ..::|.|.||.|| .:||.|..|..|:       
Human   636 --ASDSRSKGEPRDSGTLQSQE---------AKAVKKTSLFEED-EEDDLFAIAKDSQ------- 681

  Fly   785 ENEDIKKPSEVQLVKEIKAE-------ELPQQLPENKIYEITAVVEKDELVPEMLSKPQIDEPVS 842
                 ||...|.|:.|...:       ..|..:|                 |....|    |.||
Human   682 -----KKTQRVSLLFEDDVDSGGSLFGSPPTSVP-----------------PATKKK----ETVS 720

  Fly   843 ETPP---PDDYQ-------SNVDPIISMVADVTNKTSVDTLTPRKPADLAAAQQIMQNYSNLFSD 897
            |.||   .|:.:       .:||..:....:.......|.....|...|..:.|....:|:|||.
Human   721 EAPPLLFSDEEEKEAQLGVKSVDKKVESAKESLKFGRTDVAESEKEGLLTRSAQETVKHSDLFSS 785

  Fly   898 EPPDDSEFFQTLGSSGLSSLSASKIFDNEHDFFEPALPNIPSATKPSPVTPGDQP-----SVSSD 957
            ..|.|.      |:...:....| :||.|.|..|.  .||..|.: ..|..|..|     |....
Human   786 SSPWDK------GTKPRTKTVLS-LFDEEEDKMED--QNIIQAPQ-KEVGKGRDPDAHPKSTGVF 840

  Fly   958 YGAMCLFSDVPPEDND-----HAGEEVQKEAEP---------QKDELASTTRI------------ 996
            .....|||....:|||     .||.:..|..||         :.|:|.|:.:.            
Human   841 QDEELLFSHKLQKDNDPDVDLFAGTKKTKLLEPSVGSLFGDDEDDDLFSSAKSQPLVQEKKRVVK 905

  Fly   997 --HTIFYDDFSETARAGAVQPAPKRFPFDDEPPPADETDRSEVKETPELQKPTSPVKKLKMPNIN 1059
              |::  |.|.......::|.:.::..:..| .|.|.:..:..|    .::|::.:.|:: .|:.
Human   906 KDHSV--DSFKNQKHPESIQGSKEKGIWKPE-TPQDSSGLAPFK----TKEPSTRIGKIQ-ANLA 962

  Fly  1060 INVHALLPGSGS----VPKLIRKQESSSSERDEPQATVQTEAEAPSSGQNTVS-----SADGVLQ 1115
            ||..||||.:.|    |..::.:....|||...... :::....|.||:..||     .|| .|.
Human   963 INPAALLPTAASQISEVKPVLPELAFPSSEHRRSHG-LESVPVLPGSGEAGVSFDLPAQAD-TLH 1025

  Fly  1116 HVNKSRARGPAKRRPSTRRGRK--ENYAKSLLDAGQNEGPTASTRDSPEVEHSERSSIKAPSPQY 1178
            ..||||.:...||||.||..|:  ...:....|.....||.|...|.....:..|..::|.|.:.
Human  1026 SANKSRVKMRGKRRPQTRAARRLAAQESSETEDMSVPRGPIAQWADGAISPNGHRPQLRAASGED 1090

  Fly  1179 VKPEKLFSTPAQ---QIQPQLQRPPPSNTGG---SFLDSPDEDDSFFNSVPTKTVE--------G 1229
            ...|.|.:..|.   ...|.:.|.|.:.:.|   ...|..|..|.|.....:::||        .
Human  1091 STEEALAAAAAPWEGGPVPGVDRSPFAKSLGHSRGEADLFDSGDIFSTGTGSQSVERTKPKAKIA 1155

  Fly  1230 KQGTDPPKSYRS------FLDSPDADDKLFSDLENNKAGINVVPVEKKPPKMANSFLASPDEDDF 1288
            :...:||...::      .|....:||.||..            .:.||.|..|.|....||||.
Human  1156 ENPANPPVGGKAKSPMFPALGEASSDDDLFQS------------AKPKPAKKTNPFPLLEDEDDL 1208

  Fly  1289 LFD-SVKTNATTTAQKAFAAEIMNAFQKVTTAPPKPSNAKEAAKPKSQAAPKLFDDSDDDDDDLF 1352
            ..| .||.|.|.:          |:.|.|                       :....|..:||:|
Human  1209 FTDQKVKKNETKS----------NSQQDV-----------------------ILTTQDIFEDDIF 1240

  Fly  1353 ARAPSIQTASKPVQ-AKQPPKPAATSLFSSD-DEEAEVPVKSAPAKKLPVKPSKSLFSDDDDDDD 1415
            |     ..|.||.| .::..|...::||..: |..|::.||.....|..|: :||:|  |||.||
Human  1241 A-----TEAIKPSQKTREKEKTLESNLFDDNIDIFADLTVKPKEKSKKKVE-AKSIF--DDDMDD 1297

  Fly  1416 LFGGSSTSKAAAAKKTKPAARTASKPPASKTTTPTATIPSNSGDNPL 1462
            :|     |....||.|||.:|:|...|..:.....    ||..|:||
Human  1298 IF-----SSGIQAKTTKPKSRSAQAAPEPRFEHKV----SNIFDDPL 1335

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FAM21NP_611496.1 PHA03307 353..>583 CDD:223039 64/259 (25%)
PHA03307 931..>1207 CDD:223039 78/325 (24%)
CAP-ZIP_m 1045..1163 CDD:464595 38/128 (30%)
WASHC2ANP_001005751.1 Sufficient for interaction with WASHC3, WASHC4 and WASHC5, required for interaction with WASHC1. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 1..220 46/195 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 202..405 52/328 (16%)
Required for interaction with CCDC22 and VPS35L. /evidence=ECO:0000269|PubMed:25355947 356..742 111/482 (23%)
Sufficient for interaction with CCDC93. /evidence=ECO:0000269|PubMed:25355947 356..600 69/280 (25%)
Interaction with VPS35. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 357..1341 278/1158 (24%)
LFa 1. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 367..378 2/10 (20%)
LFa 2. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 411..419 3/7 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 422..554 43/137 (31%)
LFa 3. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 450..463 9/12 (75%)
LFa 4. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 482..491 2/8 (25%)
LFa 5. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 537..548 7/10 (70%)
LFa 6. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 572..583 2/10 (20%)
PTZ00108 <595..816 CDD:240271 62/302 (21%)
LFa 7. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 617..629 5/11 (45%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 621..664 9/56 (16%)
LFa 8. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 664..674 6/10 (60%)
LFa 9. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 690..702 1/11 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 696..739 11/63 (17%)
LFa 10. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 726..738 1/11 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 751..838 24/96 (25%)
LFa 11. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 803..817 6/15 (40%)
LFa 12. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 839..847 0/7 (0%)
LFa 13. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 856..862 1/5 (20%)
LFa 14. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 878..888 1/9 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 881..951 11/76 (14%)
Interaction with phospholipids. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 937..1341 121/468 (26%)
CAP-ZIP_m 943..1080 CDD:464595 39/143 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 988..1205 55/230 (24%)
Required for interaction with F-actin-capping protein subunit alpha (CAPZA1 or CAPZA2 or CAPZA3). /evidence=ECO:0000250|UniProtKB:Q9Y4E1 1029..1047 9/17 (53%)
LFa 15. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 1129..1136 2/6 (33%)
LFa 16. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 1171..1185 3/13 (23%)
LFa 17. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 1201..1209 4/7 (57%)
LFa 18. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 1234..1240 2/5 (40%)
LFa 19. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 1262..1270 3/7 (43%)
LFa 20. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 1290..1299 6/10 (60%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1302..1326 8/23 (35%)
LFa 21. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 1330..1338 3/6 (50%)

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