DRSC/TRiP Functional Genomics Resources

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Protein Alignment FAM21 and Washc2c

DIOPT Version :10

Sequence 1:NP_611496.1 Gene:FAM21 / 37331 FlyBaseID:FBgn0034529 Length:1469 Species:Drosophila melanogaster
Sequence 2:NP_954677.2 Gene:Washc2c / 297530 RGDID:735230 Length:1328 Species:Rattus norvegicus


Alignment Length:1617 Identity:373/1617 - (23%)
Similarity:587/1617 - (36%) Gaps:479/1617 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 VDQIIAQAPDWTFAGDCALLALMKRISQNLEERGERTSRNLRDFETSVKQVDIALNNATTSLRSL 71
            |::|...:.:|:.|.|..||..::..||....|.....:.:.......|.....|:|.......|
  Rat    24 VEEIRRSSQNWSLAADAGLLQFLQEFSQQTISRTHEIKKQVDGLIQETKATHCRLHNVFNDFLML 88

  Fly    72 QFGNQFVEYRVEEVDDADLAMPEEKKKKPELPLKSSEEL-----AKEFLENNLRMFRKNYEPVTI 131
            . ..||:|.||.:.:..|.|:..|.:|..:...:..:|:     .:|.:...|::....:|.:.|
  Rat    89 S-NTQFIENRVYDEEVEDQALKTEAEKAEQEKTREQKEIDLIPKVQEAVNYGLQVLDSAFEQLDI 152

  Fly   132 EV--PDSDDEDGPVHSTTVFRAKNPYDAIPLPYIIGTKEWQEHKYAGL----------------- 177
            :.  .||::||.......:...|:.|...||||:||:|.:.|.:..||                 
  Rat   153 KAGNSDSEEEDANERVELILEPKDLYIDRPLPYLIGSKLFMEQEDVGLGELSSEEGSVGSDRGSI 217

  Fly   178 YDSKENSEDDRSEEFSSSS-----------SDEKEPETKKIATPANK-------LEEQHLSDSSS 224
            .||::..|::.|::|:|.|           |||:|.:...:...:.|       :||.  :.|..
  Rat   218 VDSEDEKEEEESDDFASHSDNEQNQHITQMSDEEEDDDADLFADSEKEGDDIEDIEES--AKSKR 280

  Fly   225 LASFAREPA--IVSPVINPAVQVAEPVIRTQPRPIINSQRNPHERDMFAALRQSPPSDD-----P 282
            ..|||.|.|  |...|.|...:.     .|..:|    ||...|:..    |::|..|:     |
  Rat   281 PTSFADELAARIKGDVSNQRKEG-----HTDGKP----QRTVKEKKE----RRTPADDEEDILFP 332

  Fly   283 PSTSSSPTSSPAFRNPSSRLPIVSTASLSSSSSSPAQQPPRLFDEAVSTQTPKEAEIKPSQTKRM 347
            |.|.:....|          |..|...|.|....       |||:                    
  Rat   333 PPTLTDEDFS----------PFGSRGGLFSDRQG-------LFDD-------------------- 360

  Fly   348 PVNLFNEDEFKSFMSEIVDKVQSKTPSSSVSPATTISTKEPPKTKKPVEEYPKPGPPKQIVEQTV 412
                  :||...|                         ||.|:.:      |..||         
  Rat   361 ------DDESDLF-------------------------KEAPRGQ------PAQGP--------- 379

  Fly   413 PKRVNLFDDSPPLSPTP-RSEPVFNNTKATGAIPKRSPVVVANNDEDNSLFGSSPAM------PK 470
                 :.::||| ||.| :..|       .||:    .|.:...|...|.  |:|::      .:
  Rat   380 -----VSEESPP-SPKPGKKIP-------AGAV----SVFLGYTDVSGST--SAPSLKEFQKHEQ 425

  Fly   471 ENPSKKPPKPVTKSLFDDD----LEDDDFLSSFTPKAKPPEQKLLSKPKPSLFDDDDLDI----- 526
            ..|.|.|..|....|||||    .|||:|   |.|.:..|.:....||...:||||:.|:     
  Rat   426 STPGKGPHLPAPTGLFDDDDNDSDEDDNF---FMPSSSKPSKTDKVKPTTIIFDDDEGDLFKEKT 487

  Fly   527 ------------------DDIFTKPSAQPKKLSERVAGKTSLFEDDDQDDVTDLFGSKKAKVIPK 573
                              |...|.||::..||......:..||  .|::|..|||.|:.:.   |
  Rat   488 TALPAASVSQTDENKARTDKTITLPSSKNPKLVSETKTQKGLF--SDEEDSEDLFSSQSSS---K 547

  Fly   574 ETSSGVSPNKNVETPVASKKSLFDDIEDED-LFGTPKAKNLIRSEPDNDPEAVGEDKKQSEIAEQ 637
            ..|:.|..::    |.|| .|||.|.::|| |||:..||....|.|....|..    |.||...:
  Rat   548 TKSASVLSSQ----PPAS-VSLFGDEDEEDNLFGSAAAKKQTSSLPPQSQEKA----KPSEQPPK 603

  Fly   638 KSKNIETGEKQHQVIAENASVPILRDSPPPMEVTEQKSDDKEWEAVKDDTSAANITKSKDLFSED 702
            |:..:.:.:::.|....::...:         .:|:||..:.|:|..:....|...|..:||.|:
  Rat   604 KASALFSSDEEDQWSVADSQTKL---------ASERKSKGERWDAGTNQGQEAKAVKKTNLFEEE 659

  Fly   703 LTDD--ELFSSTSNNMAEPKSANETNEFNKPIEKYTSQTEENVSPVNPPTKLSIKPTDLFNEDFS 765
             .||  :||:                 ..|..:|.|.:|          :.|....||..:..||
  Rat   660 -DDDGVDLFA-----------------IAKDSQKKTQRT----------SLLFEDDTDSGSSLFS 696

  Fly   766 DDDTFLSASMSKNE-----PLVGTENEDIKKPSEVQLVKEIKAEELPQQLPENKIYEITAVVEKD 825
            ...|.:..:.:|.|     ||:.::.||.:.||.|:.| ::|||..... ||....::..|.:|:
  Rat   697 LPPTSVPPAATKKESIPKVPLLFSDEEDSEVPSGVKPV-DLKAENAAAS-PEVGSADVANVAQKE 759

  Fly   826 ELVPEMLSKPQIDEPVSETPPPDDYQSNVDP-----------IISMVADVTNKTSVDT------- 872
            .|:|..      |:   |...|.|..|:..|           ::|:..:..:|...|:       
  Rat   760 GLLPTS------DQ---EAGGPSDIFSSSSPLDKGAKGRTKTVLSLFDEDEDKVEDDSNTCAPQG 815

  Fly   873 ------LTPRKPADLAAAQQIMQNYSNLFS-----DEPPDDSEFFQTLGSSGLSSLSASKIF--D 924
                  .|.|:|....    :.|:...|||     |..| |.:.|.....:.||..|...:|  |
  Rat   816 GLEKGAKTDRRPKSTG----VFQDEELLFSHKLQKDNDP-DVDLFAGTKKTRLSMPSGGSLFGDD 875

  Fly   925 NEHDFFEPALPNIPSATKPS-PVTPGDQPSVSSDYGAMCLFSDVPPEDNDHAGEEVQKEAEPQKD 988
            ::.|.|..|      .|:|: ||.|..:.::..|:        .|||..:.:.|:...:||..:|
  Rat   876 DDDDLFSTA------KTQPAQPVVPEKKGTLRKDH--------KPPELTEGSKEKSTWKAETAQD 926

  Fly   989 ELASTTRIHTIFYDDFSETARAGAVQPAPKRFPFDDEPPPADETDRSEVKETPELQKPTSPVKKL 1053
            ....|                           ||                   :.::|:|.:.|:
  Rat   927 SSGLT---------------------------PF-------------------KSREPSSRIGKI 945

  Fly  1054 KMPNININVHALLPGSGSVPKLIRKQESSSSE----RDEPQATVQTEA--EAPSSGQNTVS---- 1108
            : .|:.||...|||   ||...|...:.:|||    ..||..:...||  ..|.|.:..||    
  Rat   946 Q-ANLAINPATLLP---SVAPQIPGAKPASSELAFPSSEPARSHIREAVPTLPGSEEAGVSFDLP 1006

  Fly  1109 -SADGVLQHVNKSRARGPAKRRPSTRRGRK--ENYAKSLLDAGQNEGPTASTRDSPEVEHSERSS 1170
             .|| .|...||.|.:...||||.||..|:  ...:....|...:.||......||.:.:..:..
  Rat  1007 AQAD-TLHSANKGRVKVRGKRRPQTRAARRLAAQESSEAEDVIIDRGPVTQLSSSPVLPNGHQPL 1070

  Fly  1171 IKAPSPQY----VKPEKLFSTPAQ--QIQPQLQR-------PPPSNTGGSFLDSPDEDDSFFNSV 1222
            ::   |:.    ...||..:.|.:  .:...:.|       |...|....|    |..|.|..|.
  Rat  1071 LQ---PRMASGETSSEKAMAVPWEGGPVLSAVDRSFFVKSLPQTGNEAHLF----DSGDIFPKST 1128

  Fly  1223 PTKTVEG---KQGTDPPKSYRSFLDSPDADDK--LFSDLENNKAGINVV--PVEKKPPKMANSFL 1280
            .::::||   |.|..|..|      |....:|  :|.|| :..:|::.:  ..:.:|.|..|.|.
  Rat  1129 GSQSMEGASVKAGETPAHS------SAGRKEKSLVFPDL-SEASGVDDLFQSAKPRPTKKRNPFP 1186

  Fly  1281 ASPDEDDFLFD--SVKTNATTTAQKAFAAEIMNAFQK---VTTAPPKPSNAKEAAKPKSQAAPKL 1340
            ...||:|...|  ..|....:.:.:...::..:.|:.   .|.|..||...|.  :.:....|.|
  Rat  1187 LLEDEEDLFADQKGKKNQWKSDSHQDVVSKTQDIFEDDIFATEAIKKPFPKKR--EKERTLEPNL 1249

  Fly  1341 FDDSDDDDDDLFARAPSIQTASKPVQAKQPPKPAATSLFSSDDEEAEVPVKSAPAKKLPVKPSKS 1405
            |||:.|...||            .|:.|:.||...|                          :||
  Rat  1250 FDDNIDIFADL------------TVKPKEKPKKKVT--------------------------AKS 1276

  Fly  1406 LFSDDDDDDDLFGGSSTSKAAAAKKTKPAARTASKPPASKTTTPTATIPSNSGDNPL 1462
            :|  |||.||:|     |....||.:||.:::|.  .||:..:....  ||..|:||
  Rat  1277 MF--DDDTDDIF-----SSGLQAKASKPKSQSAE--AASELRSENQV--SNIFDDPL 1322

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FAM21NP_611496.1 PHA03307 353..>583 CDD:223039 63/263 (24%)
PHA03307 931..>1207 CDD:223039 65/302 (22%)
CAP-ZIP_m 1045..1163 CDD:464595 41/130 (32%)
Washc2cNP_954677.2 Sufficient for interaction with WASHC3, WASHC4 and WASHC5, required for interaction with WASHC1. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 1..219 44/195 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 201..655 134/596 (22%)
Sufficient for interaction with CCDC93. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 346..592 85/350 (24%)
Interaction with VPS35. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 347..1328 292/1268 (23%)
LFa 1. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 357..367 5/35 (14%)
LFa 2. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 440..455 9/17 (53%)
LFa 3. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 474..483 5/8 (63%)
LFa 4. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 529..540 5/12 (42%)
LFa 5. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 564..575 5/10 (50%)
LFa 6. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 655..667 5/12 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 675..830 40/175 (23%)
LFa 7. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 683..695 3/11 (27%)
LFa 8. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 832..840 1/7 (14%)
LFa 9. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 849..855 2/6 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 863..940 25/136 (18%)
LFa 10. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 871..881 3/9 (33%)
Interaction with phospholipids. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 925..1328 119/514 (23%)
CAP-ZIP_m 931..1068 CDD:464595 44/187 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 991..1088 25/100 (25%)
Required for interaction with F-actin-capping protein subunit alpha (CAPZA1 or CAPZA2 or CAPZA3). /evidence=ECO:0000250|UniProtKB:Q9Y4E1 1017..1035 8/17 (47%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1115..1210 26/105 (25%)
LFa 11. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 1117..1124 3/10 (30%)
LFa 12. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 1157..1171 4/14 (29%)
LFa 13. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 1187..1195 3/7 (43%)
LFa 14. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 1220..1226 1/5 (20%)
LFa 15. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 1249..1257 5/7 (71%)
LFa 16. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 1277..1286 6/10 (60%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1289..1310 7/22 (32%)
LFa 17. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 1317..1325 3/6 (50%)

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