DRSC/TRiP Functional Genomics Resources

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Protein Alignment FAM21 and Washc2

DIOPT Version :10

Sequence 1:NP_611496.1 Gene:FAM21 / 37331 FlyBaseID:FBgn0034529 Length:1469 Species:Drosophila melanogaster
Sequence 2:NP_080861.2 Gene:Washc2 / 28006 MGIID:106463 Length:1334 Species:Mus musculus


Alignment Length:1606 Identity:376/1606 - (23%)
Similarity:583/1606 - (36%) Gaps:451/1606 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 VDQIIAQAPDWTFAGDCALLALMKRISQNLEERGERTSRNLRDFETSVKQVDIALNNATTSLRSL 71
            |::|...:.:|:.|.|..||..::..||....|.....:.:.......|.....|:|.......|
Mouse    24 VEEIRRSSQNWSLAADAGLLQFLQEFSQQTISRTHEIKKQVDGLIQETKATHCRLHNVFNDFLML 88

  Fly    72 QFGNQFVEYRV--EEVD------DADLAMPEEKKKKPELPLKSSEELAKEFLENNLRMFRKNYEP 128
            . ..||:|.||  |||:      :|:.|..|:.:::.|:.|...   .:|.:...|::....:|.
Mouse    89 S-NTQFIENRVYDEEVEEQVLKAEAEKAEQEKTREQKEIDLIPK---VQEAVNYGLQVLDSAFEQ 149

  Fly   129 VTIEVPDSDDEDGPVHSTT--VFRAKNPYDAIPLPYIIGTKEWQEHKYAGL-------------- 177
            :.|:..:||.|:...:...  :...|:.|...||||:||:|.:.|.:..||              
Mouse   150 LDIKAGNSDSEEDDANERVDLILEPKDLYIDRPLPYLIGSKLFMEQEDVGLGELSSEEGSVGSDR 214

  Fly   178 ---YDSKENSEDDRS-EEFSSSS-----------SDEKEPETKKIATPANK-------LEEQHLS 220
               .||::..|::.| |:|:|.|           |||:|.:...:...:.|       :||.  :
Mouse   215 GSIVDSEDEKEEEESDEDFASHSDNDQNQHTTQISDEEEDDDGDLFADSEKEGDDIEDIEES--A 277

  Fly   221 DSSSLASFAREPA--IVSPVINPAVQVAEPVIRTQPRPIINSQRNPHERDMFAALRQSPPSDD-- 281
            .|....|||.|.|  |...:.|   |..|.....:|:..:..::.          |::|..|:  
Mouse   278 KSKRPTSFADELAARIKGDISN---QRKEGQTDGKPQKTVKEKKE----------RRTPADDEED 329

  Fly   282 ---PPSTSSSPTSSPAFRNPSSRLPIVSTASLSSSSSSPAQQPPRLFDEAVSTQTPKEA-EIKPS 342
               ||.|.:....|          |..|...|.|:...       |||:...:...||| ..:|:
Mouse   330 ILFPPPTLTDEDFS----------PFGSRGGLFSNGQG-------LFDDEDESDLFKEAPRARPA 377

  Fly   343 Q---TKRMPVNLFNEDEFKSFMSEIVDKVQSKTPSSSVS-----PATTISTKEPPKTKKPVEEYP 399
            |   ::.:|.:               .|...|.|:.:||     |..:.||..|  :.|.::::.
Mouse   378 QAPVSEELPPS---------------PKPGKKIPAGAVSVLLGHPDVSGSTSAP--SLKELQKHG 425

  Fly   400 KPGPPKQIVEQTVPKRVNLFDDSPPLSPTPRSEPVFNNTKATGAIPKRSPVVVANNDEDNSLFGS 464
            :|.|.|   ...:|....||||.             :|.               |:::||:.|  
Mouse   426 QPTPGK---SSHLPTPAGLFDDD-------------DND---------------NDEDDNNFF-- 457

  Fly   465 SPAMPKEN-PSKKPPKPVTKSLFDDDLEDDDFLSSFTPKAKPPEQKLLSKPKPSLFD--DDDLDI 526
               ||..: |||......|..:|||| |.|.|           ::|..:.|..|:..  :.....
Mouse   458 ---MPSSSKPSKTDKVKSTAIIFDDD-EGDLF-----------KEKAEALPAASVSQTHESKTRA 507

  Fly   527 DDIFTKPSAQPKKLSERVAGKTSLFEDDDQDDVTDLFGSKKAKVIPKETSSGVSPNKNVETPVAS 591
            |.....||::..||......:..||  .|::|..|||.|:.:.. ||..|   .|:....|.|  
Mouse   508 DKTIALPSSKNLKLVSETKTQKGLF--SDEEDSEDLFSSQSSSK-PKSAS---LPSSQPPTSV-- 564

  Fly   592 KKSLFDDIEDED-LFGTPKAKNLIRS-EPDNDPEAVGEDKKQSEIAEQKSKNIETGEKQHQVIAE 654
              |||.|.::|| |||:..||....| :|        :.:::::.:||.||....          
Mouse   565 --SLFGDEDEEDSLFGSAAAKKQTSSLQP--------QSQEKAKPSEQPSKKTSA---------- 609

  Fly   655 NASVPILRDSPPPMEVTEQKSDDKEWEAVKDDTSAANITKSKDLFSEDLTDDELFSSTSNNMAEP 719
                 :|..|          .::.:|......|..|:..|||         .||:.|.:....|.
Mouse   610 -----LLFSS----------DEEDQWNIADSHTKLASDNKSK---------GELWDSGATQGQEA 650

  Fly   720 KSANETNEFNKPIEKYTSQTEENVSPVNPPTKLSIKPTDLFNEDFSDD-DTFLSASMSKNEPLVG 783
            |                                ::|.|:||.:|..|: |.|..|..|:      
Mouse   651 K--------------------------------AVKKTNLFEDDDDDEVDLFAIAKDSQ------ 677

  Fly   784 TENEDIKKPSEVQLVKEIKAEELPQ--QLPENKIYEITAVVEKDELVPEMLSKPQIDEPVSETP- 845
                  ||.....|:.|..||....  .||...:...|...|....||.:.|    ||..||.| 
Mouse   678 ------KKTQRTSLLFEDDAESGSSLFGLPPTSVPSATTKKESVPKVPLLFS----DEEDSEVPS 732

  Fly   846 --PPDDYQ---SNVDPIISMVADVTNKTSVDTLTPRKPADLAAAQQIMQNYSNLFSDEPPDDSEF 905
              .|:|.:   :.|.|.:.. |||.:....:.|.|       |:.|.....|::||...|.|.  
Mouse   733 GVKPEDLKVDNARVSPEVGS-ADVASIAQKEGLLP-------ASDQEAGGPSDIFSSSSPLDK-- 787

  Fly   906 FQTLGSSGLSSLSASKIFDNEHDFFEPALPNIPSATKPSPVTPGDQPSVSSDYGAMCLFSDVPPE 970
                |:.|.:....| :||.:.|..|         .:.|...|.|    ..:.|   |.:|..|:
Mouse   788 ----GAKGRTRTVLS-LFDEDEDKVE---------DESSTCAPQD----GREKG---LKTDSRPK 831

  Fly   971 DNDHAGEE-------VQKEAEPQKDELASTTRIH-------TIFYDD-----FSETARAGAVQPA 1016
            ......:|       :||:.:|..|..|.|.:|.       ::|.||     || :|:...|.|.
Mouse   832 STGVFQDEELLFSHKLQKDNDPDVDLFAGTKKIRSSVPSGGSLFGDDEDDDLFS-SAKTQPVVPE 895

  Fly  1017 PKRFPFDDEP------PPADETDRSEVKETPELQ--------------KPTSPVKKLKMPNININ 1061
            .|.....|.|      .|.|.|..|:.|.|.:.:              :|:|.:.|:: .|:.||
Mouse   896 KKGTLKKDHPVSLKNQDPLDSTQGSKEKSTWKTEPAQDSSGLTPFKSREPSSRIGKIQ-ANLAIN 959

  Fly  1062 VHALLPGSGSVPKLIRKQESSSSERDEPQA------TVQTEAEAPSSGQNTVS-----SADGVLQ 1115
            ..||||   :|...|...:..|||...|.:      .:::....|.|.:..||     .|| .|.
Mouse   960 PAALLP---TVALQIPGTKPVSSELAFPSSEPGRSHILESVPTLPGSVEAGVSFDLPAQAD-TLH 1020

  Fly  1116 HVNKSRARGPAKRRPSTRRGRK--ENYAKSLLDAGQNEGPTASTRDSPEVEHSERSSIKAPSPQY 1178
            ..||||.:...||||.||..|:  ...:....|...:.||.|....||.:.:..:..::......
Mouse  1021 SANKSRVKVRGKRRPQTRAARRLAAQESSEAEDVTVDRGPVAQLSSSPVLPNGHQPLLQPRMASG 1085

  Fly  1179 VKPEKLFSTPAQQIQPQL----------QRPPPSNTGGSFLDSPDEDDSFFNSVPTKTVEGK--Q 1231
            ....:..:.|..:..|.|          .||...|....|    |..|.|..|..:::|||.  .
Mouse  1086 QTSSETATAPPWEGGPVLSAADRSFFVKSRPQTGNEADLF----DSGDIFPKSRGSQSVEGAGVM 1146

  Fly  1232 GTDPPKSYRSFLDSPDADDK--LFSDLENNKAGINVV-PVEKKPPKMANSFLASPDEDDFLFDSV 1293
            ..:||..     .|....:|  .|.||....:..::. .|:.:..|..|.|....||:|...|  
Mouse  1147 AGEPPSH-----SSGGRKEKSLAFPDLSEGSSTEDLFQSVKPRAAKNRNPFPLLEDEEDLFAD-- 1204

  Fly  1294 KTNATTTAQKAFAAEIMNAFQKVTTAPPKPSNAKEAAKPKSQAAPKLFDDS-----DDDDDDLFA 1353
                                         |...|...||.|.      .||     |..:||:||
Mouse  1205 -----------------------------PRGKKNERKPDSH------QDSVSKTHDIFEDDIFA 1234

  Fly  1354 RAPSIQTASKPVQAK-QPPKPAATSLFSSD-DEEAEVPVKSAPAKKLPVKPSKSLFSDDDDDDDL 1416
                 ..|.||...| :..:....:||..: |..|::.||.....|..| .:||:|  |||.||:
Mouse  1235 -----TEAIKPFPKKREKGRTLEPNLFDDNIDIFADLTVKPKEKSKKKV-AAKSMF--DDDTDDI 1291

  Fly  1417 FGGSSTSKAAAAKKTKPAARTASKPPASKTTTPTATIPSNSGDNPL 1462
            |     |....||.:||.:::|......::....|:|    .|:||
Mouse  1292 F-----SSGLQAKASKPKSQSAEAASEQRSEHKVASI----FDDPL 1328

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FAM21NP_611496.1 PHA03307 353..>583 CDD:223039 56/237 (24%)
PHA03307 931..>1207 CDD:223039 79/337 (23%)
CAP-ZIP_m 1045..1163 CDD:464595 40/130 (31%)
Washc2NP_080861.2 Sufficient for interaction with WASHC3, WASHC4 and WASHC5, required for interaction with WASHC1. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 1..219 46/198 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 201..471 74/354 (21%)
Sufficient for interaction with CCDC93. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 347..594 83/336 (25%)
Interaction with VPS35. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 348..1334 295/1253 (24%)
LFa 1. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 358..368 3/9 (33%)
LFa 2. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 441..457 8/43 (19%)
LFa 3. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 476..485 6/9 (67%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 492..650 49/209 (23%)
LFa 4. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 531..542 5/12 (42%)
LFa 5. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 566..577 5/10 (50%)
LFa 6. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 658..670 5/11 (45%)
LFa 7. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 686..698 3/11 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 691..837 44/180 (24%)
LFa 8. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 835..843 1/7 (14%)
LFa 9. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 852..858 2/5 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 862..948 19/86 (22%)
LFa 10. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 874..884 3/9 (33%)
Interaction with phospholipids. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 932..1334 113/465 (24%)
CAP-ZIP_m 938..1075 CDD:464595 40/141 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1014..1225 56/257 (22%)
Required for interaction with F-actin-capping protein subunit alpha (CAPZA1 or CAPZA2 or CAPZA3). /evidence=ECO:0000250|UniProtKB:Q9Y4E1 1024..1042 9/17 (53%)
LFa 11. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 1124..1131 3/10 (30%)
LFa 12. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 1164..1178 3/13 (23%)
LFa 13. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 1194..1202 3/7 (43%)
LFa 14. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 1227..1233 2/5 (40%)
LFa 15. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 1255..1263 3/7 (43%)
LFa 16. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 1283..1292 6/10 (60%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1294..1334 10/39 (26%)
LFa 17. /evidence=ECO:0000250|UniProtKB:Q9Y4E1 1323..1331 4/10 (40%)

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