Protein Alignment FAM21 and washc2a

DIOPT Version :10

• Sequence 1: NP_611496.1
• Gene: FAM21 / 37331
• FlyBaseID: FBgn0034529
• Length: 1469
• Species: Drosophila melanogaster
• Sequence 2: XP_031762245.1
• Gene: washc2a / 100170418
• XenbaseID: XB-GENE-5771000
• Length: 1322
• Species: Xenopus tropicalis
• Alignment Length: 1631
• Identity: 388/1631 - (23%)
• Similarity: 601/1631 - (36%)
• Gaps: 508/1631 - (31%)

  Fly     7 VDQIIAQAPDWTFAGDCALLALMKRISQNLEERGERTSRNLRDFETSVKQVDIALNNATTSLRSL 71
            :::|...:.:|:...|..||..::..||....|.....:.|.......|..|..|:|.......|
 Frog    20 LEEIRRSSQNWSLGADAGLLNFLREFSQQTISRTHEIEKQLDGLIRETKATDCRLHNVFNDFLML 84

  Fly    72 QFGNQFVEYRV--EEVDD----ADLA-MPEEKKKKPELPLKSSEELAK--EFLENNLRMFRKNYE 127
            . ..||:|.||  |||:|    ||.. .||::|.:.:   |.:|.:.|  |.:...|::....:|
 Frog    85 S-NTQFIENRVYDEEVEDHVVKADAGNKPEQEKTREQ---KEAELIPKIQEAVNYGLQVLENAFE 145

  Fly   128 PVTIEVPDSDDEDGPVHSTT--VFRAKNPYDAIPLPYIIGTKEWQEHKYAGLYD--SKE------ 182
            .:.|:..:||.|:..|:...  :...|:.|...|||.:||::::.:.:..||.|  |:|
 Frog   146 QLDIKAGNSDSEEEEVNERVEPILEPKDLYIDRPLPLLIGSQQFMQQEDVGLGDLSSEEGSVDND 210

  Fly   183 -----NSEDDRSEEFSSSSSDEKEPETKKIATPANKLEEQHLSD-----------------SSSL 225
                 :|||::.:|.|....|....|.||:.:..:..:|.:.||                 .:..
 Frog   211 RGSIIDSEDEKDDEESEDDFDNNSEEEKKLHSTLSDEDEDNGSDLFGDSDKEEEEEDNKTTKTRT 275

  Fly   226 ASFAREPAIVSPVINPAVQVAEPVIRTQPRP-------IINSQRNPHERDMFAALRQSPPSDD-- 281
            .|||.|         .|.::...:.|||...       .:..::...::::     :..||||
 Frog   276 KSFADE---------LAARIQSDIPRTQESDQSSVASLEVKKKKEKDKKEV-----KKLPSDDED 326

  Fly   282 ----PPSTSSSPTSSPAFRNPSSRLPIVSTASLSSSSSSPAQQPPRLFDE---------AVSTQT 333
                ||..:....|           |..|...|.|....       |||:         .|.::.
 Frog   327 DFFKPPKLTDEDFS-----------PFGSKGGLFSGGKG-------LFDDDDDEGDIFADVPSKE 373

  Fly   334 PKEAEIKP---SQT---KRMP----VNLF--NEDEFKSFMSEIVDKVQSKTPSSSVSPATTISTK 386
            .|:||..|   |:|   |:.|    |:||  .|:...|.:....||.:|.||:..|:|      |
 Frog   374 VKKAEPSPLINSETAHLKKKPPVGGVSLFPGGENVIGSSILAEKDKNKSTTPTQDVAP------K 432

  Fly   387 EPPKTKKPVEEYPKPGPPKQIVEQTVPKRVNLFDDSPPLSPTPRSEPVF--NNTKATGAIPKRSP 449
            .||.:                         :||||.        ...:|  :|:..|...|.:|.
 Frog   433 PPPSS-------------------------SLFDDD--------DGALFGSSNSNHTTNKPGKSQ 464

  Fly   450 VVVANNDEDNSLFGSSPAMP--------KENPSKKPPKPVTKSLFDDDLEDDDFLSSFTPKAKPP 506
            .......:||.||...|..|        |||   :|||       ::::|..:.... ..|:||.
 Frog   465 PTTDLFADDNDLFQDKPVAPILAKNKVTKEN---EPPK-------ENNIESKNHQVP-VEKSKPL 518

  Fly   507 EQKLLSKPKPSLFDDDDLDIDDIFTK-PSAQPKKLSERVAGKT----SLFEDDDQDDVTDLFGSK 566
            |.....:.| .||.|:|....|:|:. |||...|.:...|.||    |||:|:|::   |||.|.
 Frog   519 ESSTKKQTK-GLFSDEDDSESDLFSPIPSASKSKTATLPAAKTGKALSLFDDEDEE---DLFASV 579

  Fly   567 KAKVIPKETSSGVSP---NKNVETPVASKKSLFDDIEDEDLFGTPKAKNLI-RSEPDNDPEAVGE 627
            ..|   |:|:....|   ||......|.|..||.. ::||..||...||.: :::|......|.:
 Frog   580 PDK---KQTAPVTKPAQQNKLTSEEKAPKSGLFSS-DEEDPIGTLNQKNTVEKTQPAKAAAVVSK 640

  Fly   628 DKKQSEIAEQKSKNIETGEKQHQVIAENASVPILRDSPPPMEVTEQKSDDKEWEAVKDDTSAANI 692
            ..::..:.::.|            :.:|       |:.....:|  |..:|:...|
 Frog   641 GTREEPLGKKSS------------LFDN-------DTDDLFAIT--KESEKKHNRV--------- 675

  Fly   693 TKSKDLFSEDLTDDELFSSTSNNMAEPKSANETNEFNKPIEKYTSQTEENVSPVNPPTKLSIKPT 757
                .|..||..:..||||.|...|.                 |||     :|||     :|:.:
 Frog   676 ----SLLFEDDNEGSLFSSVSTTAAS-----------------TSQ-----APVN-----TIEES 709

  Fly   758 DLFNEDFSDDDTFLSASMSKNEPLVGTENEDIKKPSEVQLVKEIKAEELPQQLPENKIYEITAVV 822
            .|       .||  .|.:||.|.|       :.||::.:..|  ...|.|..:.|||    ..:.
 Frog   710 KL-------PDT--HALISKKESL-------LTKPTKTEGQK--SEPEPPVSVCENK----EPLQ 752

  Fly   823 EKDELVPEMLSKPQIDEPVSETPPPDDY----QSNVDPIISMV----ADVTNKTSVDTLTPRKPA 879
            |..::...:.|:|..|...:.:||.|.:    ..||   :|:.    .|..|.|. .|:|.|.|.
 Frog   753 ENKKVKQAVFSEPGEDNLFAASPPADKHAKIKSKNV---LSLFDDEDEDFENHTD-KTITQRIPG 813

  Fly   880 DLAAAQQIMQNYSNLFSDEPPDDSEFFQTLGSSGLSSLSASKIFDNEHDFFEPALPNIPSATKPS 944
            .:::.....:..:.:|.||        :.|.|..|..       ||     :|.:....||.||
 Frog   814 KVSSETSSHKKRTGVFQDE--------ELLFSQELQK-------DN-----DPDVDLFASAKKP- 857

  Fly   945 PVTPGDQPSVSSDYGAMCLFSDVPPEDNDHAGEEVQKEAEPQKDELASTTRIHTIFYDDFSETAR 1009
               |.::||.:.....|.||.|    |.|                            ||...||:
 Frog   858 ---PSEKPSHTKSSAGMGLFGD----DED----------------------------DDLFSTAK 887

  Fly  1010 AGAVQPAPKRFPFD--------DEPPPADETD-----RSEVKETP------ELQKPTSPVKKLKM 1055
            .......|::.|.:        .|||.|.|..     |.|..|.|      :.:.|:|.:.||:
 Frog   888 PKKPPKVPEKKPVNIKEKSDAIKEPPKASEVKKDNLLRRENAECPADSVSIKSKGPSSRIGKLQ- 951

  Fly  1056 PNININVHALLPGSGSVPKLIRKQESSSSERDEPQATVQTEAEAP--SSGQNTVS----SADGVL 1114
            .|:.||..|:||  |:||||...:.:.......|.|.....:.:|  |:|...||    :....|
 Frog   952 ANLQINPAAMLP--GAVPKLAGVRPAIVGISPPPLADTMDNSTSPTASTGIQGVSFESPAQIDTL 1014

  Fly  1115 QHVNKSRARGPAKRRPSTRRGRK---ENYAKSLLDAGQNEGPTAST-RDSPEV----EHSERSSI 1171
            ...||:|.|. |:|||.||.|||   ::..:::.|:|.:  ||:.| ..:||:    .|.:..|.
 Frog  1015 HSANKARPRN-ARRRPPTRMGRKLASQDSGETIDDSGVS--PTSHTAATTPELAQLNSHQQFDST 1076

  Fly  1172 KAPSPQYVKPEKLFS-----------TP-----------AQQIQP-----QLQRPPPSN------ 1203
            .:...|.:....:.|           ||           |::..|     :.|..||.|
 Frog  1077 VSNMKQSLSENDVQSRVNTKVTTKPLTPNINDLFGSDLFAKRSLPPADASKKQDGPPDNSSANKP 1141

  Fly  1204 ---TG----GSFLDSPDEDDSFFNSVPTKTVEGKQGTDPPKSYRSFLDSPDADDKLFSDLENNKA 1261
               ||    .|.:|..:.||..|.:|..|:|:..:|.       |.:|:..:||.........|.
 Frog  1142 GLGTGTKSPASVIDEQNSDDDLFQTVKQKSVKMPKGA-------SLVDNEPSDDLFRVSKSQKKV 1199

  Fly  1262 GINVVPVEKKPPKMANSFLASPDEDDFLFDSVKTNATTTAQKAFAAEIMNAFQKVTTAPPKPSNA 1326
            .|..|..::...|.:|.|     |||.                ||.|::           ||...
 Frog  1200 DIKTVQPKETKSKASNIF-----EDDI----------------FATEVV-----------KPVKK 1232

  Fly  1327 KEAAKPKSQAAPKLFDDSDDDDDDLFARAPSIQTASKPVQAKQPPKPAATSLFSSDDEEAEVPVK 1391
            .:..||.|::  .|||::.|...||..:.                                   |
 Frog  1233 TKEKKPPSES--NLFDENVDIFADLTQKG-----------------------------------K 1260

  Fly  1392 SAPAKKLPVKPSKSLFSDDDDDDDLFGGSSTSKAAAAKKTKPAARTASKPPASKTTTPTATIPSN 1456
            ...||| .|:| ||:|  |||.||:|...|      .|.||..|    ||..:.....:.:..|:
 Frog  1261 EKKAKK-KVEP-KSIF--DDDMDDIFASGS------VKHTKQKA----KPSETSAEVKSESNVSS 1311

  Fly  1457 SGDNPL 1462
            ..|:||
 Frog  1312 IFDDPL 1317

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FAM21	NP_611496.1	PHA03307	353..>583	CDD:223039	65/247 (26%)
		PHA03307	931..>1207	CDD:223039	86/348 (25%)
		CAP-ZIP_m	1045..1163	CDD:464595	42/127 (33%)
washc2a	XP_031762245.1	CAP-ZIP_m	938..1071	CDD:464595	43/138 (31%)