DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11180 and ZNF804A

DIOPT Version :9

Sequence 1:	NP_611495.1	Gene:	CG11180 / 37330	FlyBaseID:	FBgn0034528	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	NP_919226.1	Gene:	ZNF804A / 91752	HGNCID:	21711	Length:	1209	Species:	Homo sapiens

Alignment Length:	693	Identity:	144/693 - (20%)
Similarity:	249/693 - (35%)	Gaps:	216/693 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 SGLGANLNGEKDFVRIRFKNDAEGLGFEQRDDQWTVHEDGFNGLLKSLNGEDSGGIDKEPESEEE 107
            ||....|.|.|..| :...||.  :..:...::...|.:.....:::.||.::    ..|.:.||
Human   349 SGNSFELLGNKSTV-LDMSNDC--ISVQATTEENVKHNEASTTEVENKNGPET----LAPSNTEE 406

  Fly   108 A-----RPMGFGFKAIEPEEPSKKKLKENT----SGMSLEERSKQSRARVHYK--------KFTR 155
            .     :...|..:..||..|...|.:...    |.|.:...:|.|   :.|.        |.|:
Human   407 VNITIHKKTNFCKRQCEPFVPVLNKHRSTVLQWPSEMLVYTTTKPS---ISYSCNPLCFDFKSTK 468

  Fly   156 GKDLALYSEKDLANIFGKKATEDVERYPEPVLAVQPEEPNPNFAGVQTIVTGLSTTDYFKQKMEA 220
            ..:....::.||.::..::..||:           ...|..::..|.|  .||  |||   ::.:
Human   469 VNNNLDKNKPDLKDLCSQQKQEDI-----------CMGPLSDYKDVST--EGL--TDY---EIGS 515

  Fly   221 MKNRLKKGSQVE------------DNNEAQTNGHAEKFEQISA---DNDEVTSKKKKKKKDKERA 270
            .||   |.|||.            |:.:.:..|  ::::.||.   :.::....|.:.|:|  ..
Human   516 SKN---KCSQVTPLLADDILSSSCDSGKNENTG--QRYKNISCKIRETEKYNFTKSQIKQD--TL 573

  Fly   271 DEPPTK---EEEPEQVASMPKKKKKSKRSSLDE--EKLVESEER--------------------- 309
            ||...|   :|..|......::|||.|:.....  ||..|||.|
Human   574 DEKYNKIRLKETHEYWFHKSRRKKKRKKLCQHHHMEKTKESETRCKMEAENSYTENAGKYLLEPI 638

  Fly   310 TDEQPTAVEEIEQDAPKLKKKKKSKGSSLDEIEQ---------------SENNFVEEKLV----- 354
            :::|..|.|::......|.|:.||:..||.:.|:               |..|..::..:
Human   639 SEKQYLAAEQLLDSHQLLDKRPKSESISLSDNEEMCKTWNTEYNTYDTISSKNHCKKNTILLNGQ 703

  Fly   355 ----------------------KSKERTSEQPTAVEEIEQDVPKLKKKKKSKR---SSVDETEK- 393
                                  |:|..:..|......::.|:..:.:.:..||   |.::|:|:
Human   704 SNATMIHSGKHNLTYSRTYCCWKTKMSSCSQDHRSLVLQNDMKHMSQNQAVKRGYNSVMNESERF 768

  Fly   394 ------------TDNNCVEMAEITEESERTSS--------KKKKSKKEE------ESAEVSIQTE 432
                        :|.:......:.||..|..|        |||:.:|..      |:.|:.   |
Human   769 YRKRRQHSHSYSSDESLNRQNHLPEEFLRPPSTSVAPCKPKKKRRRKRGRFHPGFETLELK---E 830

  Fly   433 ESDQKKKRKSDKN---KEIAEDSIEEPAAKKKKKSKKSDEVIVIDDDDLHRNNESHTSNENRTK- 493
            .:|...|..|..|   :.|:||         ||:..|..||..|:     ||:|.  :|:.|.|
Human   831 NTDYPVKDNSSLNPLDRLISED---------KKEKMKPQEVAKIE-----RNSEQ--TNQLRNKL 879

  Fly   494 -----NKSKSKDSQETTQIQEEITI--------DLT-----AEAPSKKKKKS---KEEKRKDN-- 535
                 |...|:.:.||..::.|.|.        |.|     |.||:|:...:   :.::|.:|
Human   880 SFHPNNLLPSETNGETEHLEMETTSGELSDVSNDPTTSVCVASAPTKEAIDNTLLEHKERSENIN 944

  Fly   536 -DEKDLEETPPASEATEKKSKKKSKL----KSSAEPSTKLEIT 573
             :||.:....|..|...::|:.||.|    .:.|.|..|:..|
Human   945 LNEKQIPFQVPNIERNFRQSQPKSYLCHYELAEALPQGKMNET 987

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11180	NP_611495.1	G-patch	27..70	CDD:279867	8/26 (31%)
ZNF804A	NP_919226.1	zf-C2H2_jaz	57..84	CDD:288983
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	380..401		3/24 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	792..860		21/79 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	96	1.000	Inparanoid score	I5047
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050