DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11180 and PINX1

DIOPT Version :9

Sequence 1:	NP_611495.1	Gene:	CG11180 / 37330	FlyBaseID:	FBgn0034528	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	NP_060354.4	Gene:	PINX1 / 54984	HGNCID:	30046	Length:	328	Species:	Homo sapiens

Alignment Length:	397	Identity:	120/397 - (30%)
Similarity:	191/397 - (48%)	Gaps:	82/397 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAMLAEPRRRKKYNLCPRGKALYEDENRFGTKMLEKMGWTKGSGLGANLNGEKDFVRIRFKNDAE 65
            |:||||.||::|:.:.|:..|...|:::||.:|||||||:||.||||...|..|.::::.||:..
Human     1 MSMLAERRRKQKWAVDPQNTAWSNDDSKFGQRMLEKMGWSKGKGLGAQEQGATDHIKVQVKNNHL 65

  Fly    66 GLGFE-QRDDQWTVHEDGFNGLLKSLN---GEDSGGIDKEPESEEEARPMGFGFKAIEPEEPSKK 126
            |||.. ..:|.|..|:|.||.||..||   |:                         |..:.|.|
Human    66 GLGATINNEDNWIAHQDDFNQLLAELNTCHGQ-------------------------ETTDSSDK 105

  Fly   127 KLKENTSGMSLEERSKQSRARVHYKKFTRGKDLALYSEKDLANIFGKKATEDVERYPEPVLAVQP 191
            |.|::   .||||:||.|:.||||.|||:||||:..|:.||..||||:.:   ::.||.  ...|
Human   106 KEKKS---FSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDLDCIFGKRQS---KKTPEG--DASP 162

  Fly   192 EEPNPNFAGVQTIVTGLST-TDYFKQKMEAMKNRLKKGSQVEDNNEAQTNGHAEKFEQISADNDE 255
            ..|..|    :|..|...| .:||.::|.|:||:                      .|:.....:
Human   163 STPEEN----ETTTTSAFTIQEYFAKRMAALKNK----------------------PQVPVPGSD 201

  Fly   256 VTSKKKKKKKDKERADEPPTKEEEPEQVASMPKKKKKSKRSSLDEEKLVESEERTDEQPTAVEEI 320
            ::..:.::|:.|:|..|...|:.|       ...:.|:||.:..:.:..|::||..::.:|..|.
Human   202 ISETQVERKRGKKRNKEATGKDVE-------SYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEE 259

  Fly   321 EQDAPKLKKKKKSKGSSL-DEIEQSENNFVEEKLVKSKERTS----EQPTAVEE---IEQDVPKL 377
            :...|...:..|:..... |.::..|.   .:..:|.|:|..    ::|..:.|   :|:.:.|.
Human   260 QLRGPCWDQSSKASAQDAGDHVQPPEG---RDFTLKPKKRRGKKKLQKPVEIAEDATLEETLVKK 321

  Fly   378 KKKKKSK 384
            ||||.||
Human   322 KKKKDSK 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11180	NP_611495.1	G-patch	27..70	CDD:279867	22/42 (52%)
PINX1	NP_060354.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28		11/26 (42%)
		G_patch	24..69	CDD:197727	22/44 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	96..115		8/46 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	147..177		10/38 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	189..307		25/149 (17%)
		Telomerase inhibitory domain (TID)	254..328		17/76 (22%)
		TBM	287..297		2/9 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149738
Domainoid	1	1.000	53	1.000	Domainoid score	I11387
eggNOG	1	0.900	-	-		E1_KOG2809
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004450
OrthoInspector	1	1.000	-	-		oto89532
orthoMCL	1	0.900	-	-		OOG6_104777
Panther	1	1.100	-	-	LDO	PTHR23149
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3734
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.700