DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11180 and ZNF804B

DIOPT Version :9

Sequence 1:	NP_611495.1	Gene:	CG11180 / 37330	FlyBaseID:	FBgn0034528	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	NP_857597.1	Gene:	ZNF804B / 219578	HGNCID:	21958	Length:	1349	Species:	Homo sapiens

Alignment Length:	724	Identity:	129/724 - (17%)
Similarity:	245/724 - (33%)	Gaps:	231/724 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 FKAIEP-EEPSKKKLKENTSGMSLEERSKQSRARVHYKKFTRGKDLALYSEKDLANIFGKKATED 178
            |.::|| |:.|...|..| |.:...|:|.....||               .|::..:..:..|.:
Human   387 FSSLEPSEQKSTVHLNPN-SRIENREKSLDKTERV---------------SKNVQRLVKEACTHN 435

  Fly   179 VERYPEPVLAVQPEEPNPN---------FAGVQTIVTGLSTTDYFKQK----------MEAMKNR 224
            |...|.|.|.||.::.:..         |...:..::......||..|          :|.:|..
Human   436 VASKPLPFLHVQSKDGHTTLQWPTELLLFTKTEPCISYGCNPLYFDFKLSRNTKEDHNLEDLKTE 500

  Fly   225 L-KKGSQVEDNNEAQTNGHAEKFEQISADNDEVTSKKKKKKKDKERADEPPTKEEEPEQVASMPK 288
            | ||..:::...|:|.:|..|                     |:::..:...:..:|:.:.:.|.
Human   501 LGKKPLELKTKRESQVSGLTE---------------------DQQKLIQEDYQYPKPKTMIANPD 544

  Fly   289 KKKKSKRSSLDEEKLVESEERTDEQPTAVEEIEQDAPKLKKKKKSKGSSLDEIEQSENNFVEEKL 353
            .:|..::.:||..   :||....|...:..::|...||:   .....:||.:. ..:||..|.||
Human   545 WEKFQRKYNLDYS---DSEPNKSEYTFSANDLEMKNPKV---PLYLNTSLKDC-AGKNNSSENKL 602

  Fly   354 VKSKERTSEQ---PTAVEEIEQD------VPKLKKKK------------------KS-------- 383
             |...|...|   ...:.:|::|      :.:.||.|                  ||
Human   603 -KEASRAHWQGCRKAVLNDIDEDLSFPSYISRFKKHKLIPCSPHLEFEDERQFNCKSSPCTVGGH 666

  Fly   384 -----------KRSSVDETEK------------TDNNCVEMAEITEESERTSSKKKKS------- 418
                       |.:.:..|.|            :..:|:.....:.::..:|....:|
Human   667 SDHGKDFSVILKSNHISMTSKVSGCGNQRYKRYSPQSCLSRYSSSLDTSPSSMSSLRSTCSSHRF 731

  Fly   419 ------------KKEEESAEVSIQ--------------TEESDQKKKRKSDKNKEIAEDSIEEPA 457
                        |:|..|.|...:              |:.|..:.:.:.::|.::.|....|..
Human   732 NGNSRGNLLCFHKREHHSVERHKRKCLKHNCFYLSDDITKSSQMQSEPQKERNCKLWESFKNEKY 796

  Fly   458 AKKK--------KKSK--------KSDEVIVIDDDD-----------------LHRNNESHTSNE 489
            :|::        |..|        ||..:|..|.:.                 .|...:|::..:
Human   797 SKRRYCHCRERQKLGKNQQQFSGLKSTRIIYCDSNSQISCTGSSKKPPNCQGTQHDRLDSYSIEK 861

  Fly   490 NRTKNKSK-SKDSQETTQIQEEITIDLTAEAPSK----------KKKKSKEEKRKDNDEKDLEET 543
            ....|||| :::|..:..|     .||....|.|          |...|...:..:::..:.|.|
Human   862 MYYLNKSKRNQESLGSPHI-----CDLGKVRPMKCNSGNISCLLKNCSSGPSETTESNTAEGERT 921

  Fly   544 PPASEATEKKSKKKSKLKSSAEPSTKLEITSFALAVEAAVDNRKD------TGGEDRNDVS-ADK 601
            |    .|.|...::.:.|...|.|:.:||:|.:...|....::..      ..|.:|..:. ::|
Human   922 P----LTAKILLERVQAKKCQEQSSNVEISSNSCKSELEAPSQVPCTIQLAPSGCNRQALPLSEK 982

  Fly   602 NNSGNKSVQSADEDLPKDLLSLEEIQEKLKSFNHFNISKFCADQFQLFDMSAFHNSSLGEIVGYG 666
            ....::|....|..:|:   :.|:.:.|....|:|.|         |.|....::.|.|.|  :.
Human   983 IQYASESRNDQDSAIPR---TTEKDKSKSSHTNNFTI---------LADTDCDNHLSKGII--HL 1033

  Fly   667 ISENVELNV 675
            ::|:..||:
Human  1034 VTESQSLNI 1042

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11180	NP_611495.1	G-patch	27..70	CDD:279867
ZNF804B	NP_857597.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	985..1010		5/27 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	96	1.000	Inparanoid score	I5047
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050